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Flashcards in DIT RNA viruses Deck (32):
1

What are the double stranded RNA viruses?

Reovirus family. Nonenveloped

Rotavirus is main cause of fatal diarrhea in kids worldwide

Coltavirus is colorado tick fever virus

2

Clinical presentation of rotavirus?

Diarrhea and vomiitng.
United states during winter months in daycare centers/kindergartens

3

What is presentation of colorado tick fever?

Coltivirus (easy to remember COL COLorado and TI for Tick fever)

Flu like illness in western mountains that resolves without treatment.

Reovirus (dsDNA)

4

What kind of virus do you see with picornavirus?

What is unique about genome?

Genome is easy b/c picoRNAvirus (small RNA virus)

PERCH on a peak (pico)
Polio
Echovirus
Rhinovirus
Coxsackievirus
HAV

One large polypeptide that is cleaved by proteases into functional viral proteins

5

What diseases cause rash on palms and soles?

Coxsackie
Meningococcus
RMSF
Syphilis

6

What three diseases can be caused by coxsackie?

positive strand RNA picoRNAvirus

Hand foot and mouth
Pericarditis
myocarditis

7

What type of virus is norovirus?
what does it cause?

Puking and shitting

ssRNA+ sense calicivirusus

8

What are the flaviviruses?

Flavi means yellow, so think jaundice annnddd... Basically shit from mosquitos that fuck you up

+ssRNA
HCV
Dengue
Yellow Fever
St luis encephalitis
West nile

9

What type of virus is yellow fever? What are symptoms?

flavivirus (means yellow)
+ssRNA

High fever, black puke (from blood), jaundice

10

Dengue fever is what virus? Symptoms?

See patient with serve muscle/joint pain, headache (retroorbital), hemorrhagic fever is possible.

Thrombocytopenia tested with tourniquet test (DIT page 299)

11

West nile causes what symptoms?

Headache, mailaise, myalgia and anorexia for 3-6 days then some get encephalitis and flaccid paralysis (like polio hitting the anterior horn)

possibly death

12

What type of virus is rubella?

Toga virus. ss+RNA
Maculopapular rash lymphadenopathy and arthralgia

13

Congenital rubella syndrome?

the R in TORCH (it is a toga virus fyi.)

Blind and Deaf blueberry with heart problems.

blueberry muffin
Cardiac defect (PDA, pulmonic stenosis)
DEAFNESS
Cataracts

14

What are the two retroviruses?

+ ssRNA

HIV and HTLV

has reverse transcriptase

15

What are two virulence factors of influenza? what type of virus?

Othomyxovirus

Hemagglutinin promotes viral attachment to host cell

Neuraminidase helps release progeny virions

16

What is most fatal aspect of influenza?

secondary bacterial infections: Strep pneumo and staph a

17

What is genetic shift?

segmented genomes traded in cells that are coinfected by different types of influenza and causes pandemics

It is genetic reassortment

18

What is mechanism of zanamivir and oseltamivir?

Neuraminidase inhibitors: block release of virus.

Influenza A and B (o is oral)

Must be used early in illness to matter

19

What causes croup?

Parainfluenza virus: Paramyoxivirus (-ssRNA)

20

What is the protein in RSV that causes cells to clump?

What drug targets it?

Syncytia is caused by F fusion protein

Palivizumab is the target for it to treat RSV in premature babies

21

Mechanism of ribavirin?

Use?

Guanosine analog

RSV and Hep C (ribavirin on interferon alpha used for hep C)

Hemolytic anemia

22

Measles symptoms? type of virus?

Paramyxovirus (rubeola)

3 C's of measles
Cough
Coryza (runny nose)
Conjunctivitis

descending rash and koplik spots (bright red spots on buccal mucosa)

23

What are koplik spots?

Red spots on buccal mucosa that precede the measles rash

24

Rash of measles?

Starts on head and moves down the body

25

Measles complications?

Fetal loss
Premature delivery
Encephalitis: can be years later

26

Roseola vs rubeola?

Roseola is HHV-6 with high fever then diffuse rash

Rubeola is measles with koplik spots then descending rash and three c's

27

Mumps is what type of virus?

Symptosm?

Paramyxovirus

POM-pom testes

Parotitis
Orchitis (leading to sterility possibly)
Meningitis

28

Rabies is what kind of virus?

Rhabdovirus (R for Rabies and RNA)

29

Capsid of rabies?

Bullet shaped, b/c old yeller had rabies, and a bullet killed him

30

What are negri bodies?

eosinophilic inclusions often in purkinje cells with rabies

31

What does hantavirus cause?

How is it spread? know that

hemorrhagic fever

progressive pulm edema and resp failure

spread by mouse urine

32

Aseptic meningitis?

Enteroviruses (echovirus and coxsackievirus), and mumps