Flashcards in DIT RNA viruses Deck (32):
What are the double stranded RNA viruses?
Reovirus family. Nonenveloped
Rotavirus is main cause of fatal diarrhea in kids worldwide
Coltavirus is colorado tick fever virus
Clinical presentation of rotavirus?
Diarrhea and vomiitng.
United states during winter months in daycare centers/kindergartens
What is presentation of colorado tick fever?
Coltivirus (easy to remember COL COLorado and TI for Tick fever)
Flu like illness in western mountains that resolves without treatment.
What kind of virus do you see with picornavirus?
What is unique about genome?
Genome is easy b/c picoRNAvirus (small RNA virus)
PERCH on a peak (pico)
One large polypeptide that is cleaved by proteases into functional viral proteins
What diseases cause rash on palms and soles?
What three diseases can be caused by coxsackie?
positive strand RNA picoRNAvirus
Hand foot and mouth
What type of virus is norovirus?
what does it cause?
Puking and shitting
ssRNA+ sense calicivirusus
What are the flaviviruses?
Flavi means yellow, so think jaundice annnddd... Basically shit from mosquitos that fuck you up
St luis encephalitis
What type of virus is yellow fever? What are symptoms?
flavivirus (means yellow)
High fever, black puke (from blood), jaundice
Dengue fever is what virus? Symptoms?
See patient with serve muscle/joint pain, headache (retroorbital), hemorrhagic fever is possible.
Thrombocytopenia tested with tourniquet test (DIT page 299)
West nile causes what symptoms?
Headache, mailaise, myalgia and anorexia for 3-6 days then some get encephalitis and flaccid paralysis (like polio hitting the anterior horn)
What type of virus is rubella?
Toga virus. ss+RNA
Maculopapular rash lymphadenopathy and arthralgia
Congenital rubella syndrome?
the R in TORCH (it is a toga virus fyi.)
Blind and Deaf blueberry with heart problems.
Cardiac defect (PDA, pulmonic stenosis)
What are the two retroviruses?
HIV and HTLV
has reverse transcriptase
What are two virulence factors of influenza? what type of virus?
Hemagglutinin promotes viral attachment to host cell
Neuraminidase helps release progeny virions
What is most fatal aspect of influenza?
secondary bacterial infections: Strep pneumo and staph a
What is genetic shift?
segmented genomes traded in cells that are coinfected by different types of influenza and causes pandemics
It is genetic reassortment
What is mechanism of zanamivir and oseltamivir?
Neuraminidase inhibitors: block release of virus.
Influenza A and B (o is oral)
Must be used early in illness to matter
What causes croup?
Parainfluenza virus: Paramyoxivirus (-ssRNA)
What is the protein in RSV that causes cells to clump?
What drug targets it?
Syncytia is caused by F fusion protein
Palivizumab is the target for it to treat RSV in premature babies
Mechanism of ribavirin?
RSV and Hep C (ribavirin on interferon alpha used for hep C)
Measles symptoms? type of virus?
3 C's of measles
Coryza (runny nose)
descending rash and koplik spots (bright red spots on buccal mucosa)
What are koplik spots?
Red spots on buccal mucosa that precede the measles rash
Rash of measles?
Starts on head and moves down the body
Encephalitis: can be years later
Roseola vs rubeola?
Roseola is HHV-6 with high fever then diffuse rash
Rubeola is measles with koplik spots then descending rash and three c's
Mumps is what type of virus?
Orchitis (leading to sterility possibly)
Rabies is what kind of virus?
Rhabdovirus (R for Rabies and RNA)
Capsid of rabies?
Bullet shaped, b/c old yeller had rabies, and a bullet killed him
What are negri bodies?
eosinophilic inclusions often in purkinje cells with rabies
What does hantavirus cause?
How is it spread? know that
progressive pulm edema and resp failure
spread by mouse urine