DIT RNA viruses Flashcards
What are the double stranded RNA viruses?
Reovirus family. Nonenveloped
Rotavirus is main cause of fatal diarrhea in kids worldwide
Coltavirus is colorado tick fever virus
Clinical presentation of rotavirus?
Diarrhea and vomiitng.
United states during winter months in daycare centers/kindergartens
What is presentation of colorado tick fever?
Coltivirus (easy to remember COL COLorado and TI for Tick fever)
Flu like illness in western mountains that resolves without treatment.
Reovirus (dsDNA)
What kind of virus do you see with picornavirus?
What is unique about genome?
Genome is easy b/c picoRNAvirus (small RNA virus)
PERCH on a peak (pico) Polio Echovirus Rhinovirus Coxsackievirus HAV
One large polypeptide that is cleaved by proteases into functional viral proteins
What diseases cause rash on palms and soles?
Coxsackie
Meningococcus
RMSF
Syphilis
What three diseases can be caused by coxsackie?
positive strand RNA picoRNAvirus
Hand foot and mouth
Pericarditis
myocarditis
What type of virus is norovirus?
what does it cause?
Puking and shitting
ssRNA+ sense calicivirusus
What are the flaviviruses?
Flavi means yellow, so think jaundice annnddd… Basically shit from mosquitos that fuck you up
\+ssRNA HCV Dengue Yellow Fever St luis encephalitis West nile
What type of virus is yellow fever? What are symptoms?
flavivirus (means yellow)
+ssRNA
High fever, black puke (from blood), jaundice
Dengue fever is what virus? Symptoms?
See patient with serve muscle/joint pain, headache (retroorbital), hemorrhagic fever is possible.
Thrombocytopenia tested with tourniquet test (DIT page 299)
West nile causes what symptoms?
Headache, mailaise, myalgia and anorexia for 3-6 days then some get encephalitis and flaccid paralysis (like polio hitting the anterior horn)
possibly death
What type of virus is rubella?
Toga virus. ss+RNA
Maculopapular rash lymphadenopathy and arthralgia
Congenital rubella syndrome?
the R in TORCH (it is a toga virus fyi.)
Blind and Deaf blueberry with heart problems.
blueberry muffin
Cardiac defect (PDA, pulmonic stenosis)
DEAFNESS
Cataracts
What are the two retroviruses?
+ ssRNA
HIV and HTLV
has reverse transcriptase
What are two virulence factors of influenza? what type of virus?
Othomyxovirus
Hemagglutinin promotes viral attachment to host cell
Neuraminidase helps release progeny virions
What is most fatal aspect of influenza?
secondary bacterial infections: Strep pneumo and staph a
What is genetic shift?
segmented genomes traded in cells that are coinfected by different types of influenza and causes pandemics
It is genetic reassortment
What is mechanism of zanamivir and oseltamivir?
Neuraminidase inhibitors: block release of virus.
Influenza A and B (o is oral)
Must be used early in illness to matter
What causes croup?
Parainfluenza virus: Paramyoxivirus (-ssRNA)
What is the protein in RSV that causes cells to clump?
What drug targets it?
Syncytia is caused by F fusion protein
Palivizumab is the target for it to treat RSV in premature babies
Mechanism of ribavirin?
Use?
Guanosine analog
RSV and Hep C (ribavirin on interferon alpha used for hep C)
Hemolytic anemia
Measles symptoms? type of virus?
Paramyxovirus (rubeola)
3 C’s of measles
Cough
Coryza (runny nose)
Conjunctivitis
descending rash and koplik spots (bright red spots on buccal mucosa)
What are koplik spots?
Red spots on buccal mucosa that precede the measles rash
Rash of measles?
Starts on head and moves down the body
