DIT weird bacteria

Question 1

What is leptospira interrogans?

Answer 1

question mark shaped bacteria b/c (INTERROGATEs)

Surfer in tropics (interrogate in point break).

Symptoms: early is flue like symptom and photophobia. THEN WEIL disease: WEILLY Bad. azotemia and liver/kidney dysfunction, fever, hemorrhage

Question 2

What do you think if you see urine contaminated with urine?

Answer 2

Leptospira, hantavirus

Question 3

Lyme disease mnemonic?

Answer 3

FAKE a key LYME pie

Facial nerve paralysis (bilateral)
Arthritis
Kardiac (AV) block
Erythema migrans

Question 4

Tx for lyme disease? Stage 1 or stage 2 tx?

Late disease?

Answer 4

Doxy for early

Stage 3 (years later with subacute encephalitis and stuff is IV ceftriaxone)

Question 5

Hand and foot rash mnemonic?

Answer 5

drive Kawasaki CARS with hands and feet.

Kawasaki
Coxcacki A
RMSF
Syphilis

Question 6

Tertiary syphilis has what?

Answer 6

Gummas: chronic granulomas
Aortitis: tree bark aorta
Tabes dorsalis (sensory ataxia and positive rhomberg)
Argyll robertson (no light constriction but accommodation constriction is there)
Charcot’s joints: damage b/c slamming it into shit b/c pain doesn’t happen

Question 7

Hutchinson teeth?

Answer 7

Weird looking teeth from congenital syphilis.

Treat early.

Question 8

How do you recognize congenital syphilis in clinic?

Answer 8

Snuffles: bloody drips from nose.

Treat it and may prevent outcomes like saber shins, hutch teeth, mulberry molars, saddle nose…

Question 9

What are VDRL/RPR?

Answer 9

Recognize serologic find antibodies in serum.

Can do false positive and confirm with FTA-ABS which is specific

Question 10

Tx of primary syphilis?

Answer 10

Penicillin G, if allergic, use doxy

Question 11

VDRL false positive?

Answer 11

VDRL

Virus
Drugs
Rheum fever
Lupus

Confirmwith FTA-ABS

Question 12

Bartonella source?

Answer 12

cat scratch

Question 13

Borrelia burgdorferi?

Answer 13

Ixodes tick (deer/mice)

Question 14

Borrelia recurrentis

Answer 14

Tick and lice (relapsing fever)

Question 15

Brucella?

Answer 15

undulant fever unpasturized milk

Question 16

Campylobacter?

Answer 16

Pet contaminated fecal oral

Question 17

Chlamydophila psittaci

Answer 17

Pneumonia parrots

Question 18

Coxiella burnetii

Answer 18

Q fever: cattle placenta

Question 19

Ehrlihia chaggeensis

Answer 19

Headache and blunt immune symptoms lone star tick

Question 20

Francisella tularensis

Answer 20

Ticks and rabits (rabbit eating tulip on test

Question 21

Leptospira interrigans

Answer 21

Animal urine

Question 22

Pasteurella

Answer 22

cellulitis animal bites

Question 23

Yersinia pestis?

Answer 23

prarie dogs and rats fleas

Question 24

What disease might have bell’s palsy? Mnemonic

Answer 24

My Lovely Belle Had An STD

Lyme
Herpes Zoster
AIDS
Sarcoid
Tumor
Diabetes

Question 25

What is a ghon complex?

Answer 25

Hilar lymph and ghon focus on x ray. Primary Tb

Question 26

Primary tb vs secondary in the lung?

Answer 26

Primary is ghon complex in mid lung Secondary is cavitation with cavitary caseous necrosis in upper lobes and more symptoms

Question 27

What bacteria often goes to back?

Answer 27

mycobacterium Tb in pott diseaes in extrapulmonary secondary Tb Also can ht CNS, lymph, renal, GI, adrenal

Question 28

Mechanism for drug for latent tb? What do you add to reduce toxicity?

Answer 28

INH is blocking synth of my colic acid and needs to be actriavatvie by catalase pyridoxine helps with neuro and hepatotoxicity Also causes lupus

Question 29

Primary or secondary Tb tx?

Answer 29

RIPE Rifampin Isoniazid Pyrazinamide (acidifies lysosomes of macrophage) Ethambutol (less carb poly of mycobacterium cell wall and optic neuropathy)

Question 30

Two kinds of leprosy? Tx for each?

Answer 30

Lepromatous is worse and communicable. Humoral response Th2 Tx: Dapsone, rifampin, clofazimine for 2-5 years Tuberculoid: Tb some hairless skin plaques and cell0mediated immunity with Th1 Tx: dapsone and rifampin

Question 31

Dapsone toxicity? When is it used?

Answer 31

Hemolysis in G6PD ``` PCP pnuemonia (in addition to TMP SMX) Lepromatous ```

Question 32

When is rifampin used?

Answer 32

Tb Leprosy Meningitis prophylaxis: menigiococcal, H influenzae type B

Question 33

Toxicity of RIPE regiment?

Answer 33

basically look out for hepatotoxicities

Question 34

Gardnerella symptoms and tx?

Answer 34

Vaginosis: gray discharge and fishy smell Clue cells! Metronidazole

Question 35

Ricketsia triad and tx?

Answer 35

Headache fever and rash Tx: Doxy

Question 36

Where do ricketsial rashes start?

Answer 36

Ricketssia Rickets starts on wrRists and spreads in and includes soles R typhi stratrts on Trunk and moves out sparing soles (also prowazeki)

Question 37

Difference between endemic typhus and epidemic typhus?

Answer 37

Endemic is typhi from fleas Epidemic is outbreaks from louse (lice) and prowazekii Both start in central and spread but spare soles/palm

Question 38

What is Q fever? what causes it?

Answer 38

Q fever is from Coxiella burnetii and similar to rickets No rash or vector and is from cow placenta and has spores inhaled as aerosols and causes fever and pneumonia Tx with doxy

Question 39

What is weil felix reaction?

Answer 39

for rickets antibodies. Doesn't work for Q fever (coxiella burnetii)

Question 40

What is chlamydia psittaci?

Answer 40

Pnrumonia from birds that can spread systemically

Question 41

Chlamydia trachomatis A, B and C?

Answer 41

Africa Blindness/Chronic infection

Question 42

What is lymphogranuloma venereum? What can it be mistaken for?

Answer 42

Painless ulcers on genital that later are painful and ulcerate. Can cause rectal disease and mimic IBD. Doxy is tx B/c chlamydia

Question 43

What are cold agglutins? How do you treat causing bug?

Answer 43

IgM agglutinate or lyse RBC in cold environment Seen with mycoplasma Macrolide or doy or fluoroquinolone

Question 44

What is coxiella burnetti?

Answer 44

Q fever cause. Cattle placenta and tick shit. Spores releasesd and inhaled Pneumnia and Q fever is Queer: no rash or vector. No Weil-Felix (ricketsia test)