DIT HIV Flashcards
(34 cards)
Most common artery involved in thrombus?
LAD
HIV genome?
Diploid. 2 molecules of RNA
The three genes in HIV?
Know
env: envelope: gp120 and gp40
gag: p24 capsid protein
pol: reverse transcriptase, aspartate protease and integrase
What do the two things in the env gene do?
gp120: binds to CD4 and CCR5 in macrophage or CXCR4 in CD4 cells
gp41 is fusion and entry
Reverse transcriptase works where?
Reverse transcriptase is in cytoplasm and makes dsDNA which moves to nucleus and the DNA is integrated into dan with integrase
What makes you suspect PCP?
CD4<200 and interstitial infiltrates on CXR
AIDs patient with CD4<50, presents with resp issue. What do you suspect?
PCP
TB
Mycobacterium avium complex (MAC)
Ssytemic disease in HIV with CD4<100?
Histoplasma. Low grade fever, cough, hepatosplenomegaly, tongue ulcer
AIDs with meningitis?
Cryptococcal
If multiple ring abscess, its toxoplasmosis
if single ring, think primary CNS lymphoma
Cotton spots on retina in AIDs?
CMV. needs ganciclovir. “sightomegalovirus”
CD4 less than 50
What is progressive multifocal leukoencephalopathy?
Reactivation of JC virus (less than 200)
Diarrhea that is chronic and watery in AIDs?
Cryptosporidium. Acid fast cysts in stool
When do you see esophageal candidiasis? What is the biggest problem?
Very difficult to eat b/c it is painful
CD4 less than 100
Oral hairy leukoplakia is what?
EBV with HIV
What does primary CNS lymphoma look like on MRI.
Whats it associated with?
Ring lesions. Must differentiate from toxoplasmosis
Associaed with EBV
Squamous cell carcinoma and large B cell lymphoma can both happen in AIDs. What are they associated with?
B lymphoma is EBV
Squamous is HPV
When do you start prophylaxis with HIV?
For what prophylactic treatment?
CD4<50 is azithromycin for Mycobacterium avium
What are the protease inhibitors?
-Navir (Navir tease a proTEASE)
Indinavir side effects
same as other protease inhib + nephrolithisasis and hematuria
Atazanivir side effects?
same as protease inhibitors with also…
Increased bilirubin and nephrolithiasis (kidney and renal)
Protease inhibitors common side effects?
Nausea, diarrhea, hyperglycemia and lypodystrophy
How do NRTIs work?
Nucleoside analogs, and is lacking 3’ OH and stops polymerization
They are competitive inhibitors
THEY MUST BE ACTIVATED by thymidine kinase
Bone marrow suppression is caused by what anti HIV drug?
Zidovudine
Pancreatitis from anti HIV drug?
didanosine
