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Flashcards in DIT HIV Deck (34):
1

Most common artery involved in thrombus?

LAD

2

HIV genome?

Diploid. 2 molecules of RNA

3

The three genes in HIV?

Know

env: envelope: gp120 and gp40

gag: p24 capsid protein

pol: reverse transcriptase, aspartate protease and integrase

4

What do the two things in the env gene do?

gp120: binds to CD4 and CCR5 in macrophage or CXCR4 in CD4 cells

gp41 is fusion and entry

5

Reverse transcriptase works where?

Reverse transcriptase is in cytoplasm and makes dsDNA which moves to nucleus and the DNA is integrated into dan with integrase

6

What makes you suspect PCP?

CD4<200 and interstitial infiltrates on CXR

7

AIDs patient with CD4<50, presents with resp issue. What do you suspect?

PCP
TB
Mycobacterium avium complex (MAC)

8

Ssytemic disease in HIV with CD4<100?

Histoplasma. Low grade fever, cough, hepatosplenomegaly, tongue ulcer

9

AIDs with meningitis?

Cryptococcal

If multiple ring abscess, its toxoplasmosis

if single ring, think primary CNS lymphoma

10

Cotton spots on retina in AIDs?

CMV. needs ganciclovir. "sightomegalovirus"

CD4 less than 50

11

What is progressive multifocal leukoencephalopathy?

Reactivation of JC virus (less than 200)

12

Diarrhea that is chronic and watery in AIDs?

Cryptosporidium. Acid fast cysts in stool

13

When do you see esophageal candidiasis? What is the biggest problem?

Very difficult to eat b/c it is painful

CD4 less than 100

14

Oral hairy leukoplakia is what?

EBV with HIV

15

What does primary CNS lymphoma look like on MRI.

Whats it associated with?

Ring lesions. Must differentiate from toxoplasmosis

Associaed with EBV

16

Squamous cell carcinoma and large B cell lymphoma can both happen in AIDs. What are they associated with?

B lymphoma is EBV

Squamous is HPV

17

When do you start prophylaxis with HIV?

For what prophylactic treatment?

CD4<50 is azithromycin for Mycobacterium avium

18

What are the protease inhibitors?

-Navir (Navir tease a proTEASE)

19

Indinavir side effects

same as other protease inhib + nephrolithisasis and hematuria

20

Atazanivir side effects?

same as protease inhibitors with also...

Increased bilirubin and nephrolithiasis (kidney and renal)

21

Protease inhibitors common side effects?

Nausea, diarrhea, hyperglycemia and lypodystrophy

22

How do NRTIs work?

Nucleoside analogs, and is lacking 3' OH and stops polymerization

They are competitive inhibitors

THEY MUST BE ACTIVATED by thymidine kinase

23

Bone marrow suppression is caused by what anti HIV drug?

Zidovudine

24

Pancreatitis from anti HIV drug?

didanosine

25

Which NRTI is not a nucleosie but is instead a nucleotide?

Tenofovir is nucleoTide and doesn't need to be activated

26

What are the NRTI's?

Zoos Like Dem African Elephants

Zidovudine
Lamivudine
Didanosine (pancreatitis)
Abacavir (hypersensitivity)
Emtricitabine

and other vudines

27

What anti HIV can cause life threatening hypersensitivity?

Abacavir

28

Mechanism on NNRTIs?

Noncompetivitely bind reverse transcriptase and don't need to be phosphorylates

29

What anti HIV drug can cause neuropsychiatric symptoms?

Efavirenz (also test positive for cannibioids, makes sense)

30

What is side effect common to all NNRTIs?

Rash and hepatotoxicity

31

Mechanism of enfuvirtide?

gp41 so prevents enFUsion

32

Mechanism of Maraviroc?

CCR5 antagonist so gp120 can't bind macrophage effectively.

Must do tropism test to make sure it is R5 virus (only used in all R5)

33

Mechanism of raltegravir? side effect?

inhibits integrase. hypercholesterolemia (but she didn't say it)

34

What can CMV cause if you have HIV?

Retinitis )
Interstitial pneumonia