Flashcards in DIT Immunosuppressants MEchanism and side effects for each Deck (12):
Binds cyclophilin and inhibits calcineurin and IL-2 produciton stopped so no T cell activation
Binds FK binding proteins and inhibits calcineurin to inhibit IL-2 (similar to cyclosporine)
Binds FKBP-12 with blocks MTOR and IL-2 response is blocked (no downstream effects)
Dont stress side effects
Precursor of 6-MP (prodrug_
Interfere with nucleic acid synthesis
Bone marrow suppression.
METABOLIZED BY XANTHINE OXIDASE so allopurionl makes it worse (6MP broken down by it too)
Inhibits IMP-dehydrogenase so no guanine is made
Prevents B and T cell proliferation
Risk of lymphoma, miscariage
Binds CD3 on T cells to prevent acute transplant rejection.
T cell can't do signal transduction
Binds CD25: IL-2 receptor on activated T cells
No IL-2 signalling (similar as sarolimus)
Inhibits new vessel formation
Anti TNFalpha drugs?
Inlfiximab, adalimumab, ETANERCEPT (decoy receptor)
PAIR diseases (B27)!