DIT Immunosuppressants MEchanism and side effects for each Flashcards Preview

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Flashcards in DIT Immunosuppressants MEchanism and side effects for each Deck (12):
1

Cyclosporine?

Binds cyclophilin and inhibits calcineurin and IL-2 produciton stopped so no T cell activation

NEPHROTOXIC
HTN

2

Tacrolimus?

Binds FK binding proteins and inhibits calcineurin to inhibit IL-2 (similar to cyclosporine)

Nephrotoxic
HTN
Neurotixicity

3

Sirolimus

Binds FKBP-12 with blocks MTOR and IL-2 response is blocked (no downstream effects)

Dont stress side effects

4

Aziothioprine?

Precursor of 6-MP (prodrug_

Interfere with nucleic acid synthesis

Side effects:
Bone marrow suppression.

METABOLIZED BY XANTHINE OXIDASE so allopurionl makes it worse (6MP broken down by it too)

5

Mycophenolate

Inhibits IMP-dehydrogenase so no guanine is made

Prevents B and T cell proliferation

Risk of lymphoma, miscariage

6

Muromonab?

Binds CD3 on T cells to prevent acute transplant rejection.

T cell can't do signal transduction

7

Daclizumab?

Binds CD25: IL-2 receptor on activated T cells

No IL-2 signalling (similar as sarolimus)

8

Thalidomide?

Blocks TNFalpha.

Inhibits new vessel formation

9

Anti TNFalpha drugs?

Inlfiximab, adalimumab, ETANERCEPT (decoy receptor)

PAIR diseases (B27)!
Psoriasitic arthritis
Ankylosing spondylitis
IBD
Reactive arthritis
Rheumatoid arthritis

10

Abciximab?

Anti GpIIbIIIa

11

Trastuzumab?

Anti Her2

12

Omalizumab?

Anti IgE for severe asthma (but expensive so rarely used)