Flashcards in EXAM #1: MICROCYTIC ANEMIA Deck (63)
What is the most important point to remember about anemia?
Anemia is NOT a concluding diagnosis; it is a manifestation of disease
What is the definition of anemia?
Decreased RBC resulting in decreased oxygen carrying capacity
What are the common symptoms of anemia?
What is the normal MCV of RBCs?
What is the definition of microcytic anemia?
Less than 80 fl MCV
What is the rule of thumb for determining the size of a RBC on PBS?
- Lymphocyte nucleus
- Central pallor is roughly 1/3 of the RBC width
What are the hallmark features of microcytosis on PBS?
What is a normal Hb for men?
What is a normal Hb for women?
What is a normal Hct in men?
What is a normal Hct in women?
What is the normal MCH?
Mean Corpusucular Hb
What is the normal MCHC?
Mean Corpusucular Hb Concentration
What is the normal RDW?
Red Cell Distribution Width
*****Note that the smaller the RDW, the more UNIFORM the size*****
What are the three causes of iron deficiency?
1) Inadequate absorption
2) Inadequate utilization
3) Excessive loss******
*****This is the most common cause
How much iron can be absorbed per day?
Where in the body is iron absorbed?
First and second parts of the duodenum
What is the difference between ferrous and ferric iron?
What form of iron is most efficiently absorbed?
Are plants a good source of iron?
- Low in iron to begin with
- Most is Fe+++
What transporter is important for the absorption of Fe++?
Divalent Metal Transporter
What happens to Fe++ once it is absorbed into the enterocyte?
How does iron/ferretin leave the enterocyte?
How is iron transported in the blood?
Plasma transferrin i.e. carrier protein
What blocks the ferroportin transporter?
Hepcidin (made in the liver)
What is the iron cycle?
1) Iron enters the gut and into the circulation
2) Transferrin transports iron in the blood to the bone marrow
3) Bone marrow to makes RBCs
4) Old RBCs are recycled in the spleen and iron is stored
5) Iron is released back into the blood to repeat the cycle
What upregulates hepcidin?
High circulating ferretin
What downregulates hepcidin?
What organ produces EPO? What is the function of EPO?
- Kidneys (renal fibroblasts)
- EPO stimulates erythropoiesis