EXAM #3: PATHOLOGY OF LYMPHOMA Flashcards Preview

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Flashcards in EXAM #3: PATHOLOGY OF LYMPHOMA Deck (52)
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1

Draw the cortex of the lymph node, label the location of Follicilar, Marginal, and Mantle cell lymphoma.

N/A

2

What is the gross appearance of a Follicular Lymphoma?

Nodular

3

What is the typical age of onset of Follicular Lymphoma?

Middle age

4

What are the clinical findings associated with Follicular Lymphoma?

1) LAD
2) Splenomegaly

5

What cells compose Follicular Lymphoma? How do you tell the difference?

Follicle germinal center cells:
- Centroblasts= loose/ less dense nucleus
- Centrocytes

6

What is the difference between a low grade and high grade Follicular Lymphoma?

Low= centrocytes
High= centroblasts i.e. less differentiated

7

What translocation is associated with Follicular Lymphoma?

t(14:18)

8

What protein is overexpressed in Follicular Lymphoma?

Bcl-2, which inhibits apoptosis i.e. is anti-apoptotic

9

What is the immunostaining phenotype of Follicular Lymphoma?

CD10*
CD19
CD20
Bcl-2*

10

What is Mantle Cell Lymphoma? How is the gross appearance different from Follicular Lymphoma?

Neoplastic proliferation of small B-cells in the mantle zone of the lymph node

****Lymph nodes are SMOOTH grossly****

11

What is the typical presentation of Mantle Cell Lymphoma?

Painless lymphadenopathy in late adulthood (5th-6th decade)

12

What is the translocation associated with Mantle Cell Lymphoma?

t(11:14)

13

What protein is overexpressed in Mantle Cell Lymphoma?

Cyclin D1, which mediates G1-->S-phase transition

****Pro-proliferative****

14

What is the immunophenotype of Mantle Cell Lymphoma?

CD5
CD19
CD20
Cyclin D1

15

What is Burkitt's Lymphoma?

Neoplastic proliferation of INTERMEDIATE sized CD20+ B-cells

16

What is the classic presentation of Burkitt's Lymphoma?

Extranodal mass in a child or young adult

17

What is the difference between the African and Sporadic forms of Burkitt's Lymhoma?

African= involves the jaw and seen in kids between 4 and 7 years old

Sporadic= involves the abdomen (ileocecal) and median age is 30

18

What is immunodeficiency-associated BL?

HIV+ patients present with Burkitt's Lymphoma, a manifestation of progression to AIDS

19

What viral infection is associated with Burkitt's Lymphoma?

EBV

20

What translocation is associated with Burkitt's Lymphoma?

t(8:14)

21

What protein is Burkitt's Lymphoma?

C-myc

22

What are the characteristics of Burkitt's Lymphoma on microscopy?

1) Diffuse monomorphic infiltrate with High mitotic index
2) "Starry-sky" appearance

23

What are tingable body macrophages?

Tingable= stainable

Macrophages found in germinal centers containing phagocytozed apoptotic cells (tingable bodies)

24

What is the immunophenotype of Burkitt's Lymphoma?

CD10
CD19
CD20
C-myc

25

What is Adult T-cell Leukemia/ Lymphoma?

Neoplastic proliferation of CD4+ T-cells

26

What virus is Adult T-cell Leukemia/ Lymphoma associated with?

HTLV-1

****Seen in Japan, Central Africa, Caribbean***

27

What population is affected by Adult T-cell Leukemia/ Lymphoma?

Adults ONLY

28

What are the common clinical findings associated with Adult T-cell Leukemia/ Lymphoma??

1) Rash
2) Generalized LAD
3) Hepatosplenomegaly
4) Lytic bone lesions
5) Hypercalcemia

29

How does the morphology of cells in Adult T-cell Leukemia/ Lymphoma vary?

Immature= smooth

Mature= Flower cells

30

What disease are Flower Cells associated with?

Adult T-cell Leukemia/ Lymphoma