EXAM #3: LYMPHOMA II Flashcards Preview

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Flashcards in EXAM #3: LYMPHOMA II Deck (56)
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1

What is the age distribution of HL?

Bimodal distribution:
1) 2nd and 3rd decades
2) Older than 50

2

Describe the presentation of HL.

B Symptoms:
- Fever
- Chills
- Night sweats
- Pruritus
- Weight loss
- Lymphadenopathy, mostly above the diaphragm

3

How is the lymphadenopathy in HL described?

Contiguous and nontender

(vs. sporadic in NHL)

4

How is HL diagnosed?

1) Lymph node biopsy
2) CBC and acute phase reactants
3) PET scan
4) Bone marrow biopsy

5

How is HL staged?

I= 1x nodal region
II= 2x nodal regions on one side of the diaphragm
III= Both sides of the diaphragm
IV= more than one extranodal site

6

What does A mean in HL?

asymptomatic

7

What does B mean in HL?

B symptoms

8

What does X mean in HL?

"Bulky Disease"

9

What cell is there a neoplastic proliferation of in HL?

Reed-Sternberg

(ALWAYS a B-cell cancer)

10

What are the characteristics of RS cells?

1) Mulilobed nuclei
2) Owl eye
3) CD15 and CD30 positive

11

What are the subtypes of HL?

Nodular sclerosis
Lymphocyte rich
Mixed cellularity
Lymphocyte-depleted

12

What is the most common subtype of HL?

Nodular sclerosis

13

What subtype of HL has the best prognosis?

Lymphocyte-rich

14

What is the subtype of HL with the worst prognosis?

Lymphocyte-depleted

15

How is HL treated?

1) Chemotherapy (I-IIA)
2) Radiation (IIB- IV)

16

What is the standard chemotherapy regimen for HL?

ABVD regimen:
- Adriamycin
- Bleomycin
- Vinblastine
- Dacarbazine

17

What is more common, HL or NHL?

NHL

18

What infection is associated with Burkitt's Lymphoma and Nasopharygeal Lymphoma?

EBV

19

What infection is associated with Adult T-cell Lymphoma/Leukemia?

HTLV-1

20

What infection is associated with Gastric MALT Lymhoma?

H. pylori

21

What is the most common etiologic factor in NHL?

Prior chemotherapy and radiation

22

How is NHL diagnosed?

Lymph node biopsy
Bone marrow biopsy

23

How does the presentation of HL and NHL differ?

B-symptoms are only seen in v. aggressive NHL

24

What is the additional procedure that may be required for the diagnosis of NHL?

Lumbar puncture

25

What is the translocation seen in Follicular Lymphoma?

t(14:18), bcl-2

26

What is the translocation seen in SLL?

t(14:19), bcl-3

27

What is the translocation seen in Mantle Cell Lymphoma?

t(11:14), Cyclin D1

28

What is the translocation seen in Burkitt's Lymphoma?

t(8:14), c-myc

29

What is the translocation seen in Diffuse Large B-Cell Lymphoma (DLCL)?

t(3:14), bcl-6

30

What is the most common type of NHL?

Diffuse Large B-Cell Lymphoma