Flashcards in EXAM #3: LYMPHOMA II Deck (56)
What is the age distribution of HL?
1) 2nd and 3rd decades
2) Older than 50
Describe the presentation of HL.
- Night sweats
- Weight loss
- Lymphadenopathy, mostly above the diaphragm
How is the lymphadenopathy in HL described?
Contiguous and nontender
(vs. sporadic in NHL)
How is HL diagnosed?
1) Lymph node biopsy
2) CBC and acute phase reactants
3) PET scan
4) Bone marrow biopsy
How is HL staged?
I= 1x nodal region
II= 2x nodal regions on one side of the diaphragm
III= Both sides of the diaphragm
IV= more than one extranodal site
What does A mean in HL?
What does B mean in HL?
What does X mean in HL?
What cell is there a neoplastic proliferation of in HL?
(ALWAYS a B-cell cancer)
What are the characteristics of RS cells?
1) Mulilobed nuclei
2) Owl eye
3) CD15 and CD30 positive
What are the subtypes of HL?
What is the most common subtype of HL?
What subtype of HL has the best prognosis?
What is the subtype of HL with the worst prognosis?
How is HL treated?
1) Chemotherapy (I-IIA)
2) Radiation (IIB- IV)
What is the standard chemotherapy regimen for HL?
What is more common, HL or NHL?
What infection is associated with Burkitt's Lymphoma and Nasopharygeal Lymphoma?
What infection is associated with Adult T-cell Lymphoma/Leukemia?
What infection is associated with Gastric MALT Lymhoma?
What is the most common etiologic factor in NHL?
Prior chemotherapy and radiation
How is NHL diagnosed?
Lymph node biopsy
Bone marrow biopsy
How does the presentation of HL and NHL differ?
B-symptoms are only seen in v. aggressive NHL
What is the additional procedure that may be required for the diagnosis of NHL?
What is the translocation seen in Follicular Lymphoma?
What is the translocation seen in SLL?
What is the translocation seen in Mantle Cell Lymphoma?
t(11:14), Cyclin D1
What is the translocation seen in Burkitt's Lymphoma?
What is the translocation seen in Diffuse Large B-Cell Lymphoma (DLCL)?