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Hematology and Oncology > First Aid Review > Flashcards

Flashcards in First Aid Review Deck (72)
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1

Azurophilic granules contain...

Proteinases, acid phosphatase, myeloperoxidase, and beta-glucuronidase

2

Hypersegmented polys (5 or more lobes) are seen in...

Vitamin B12/folate deficiency

3

Increase in % band cells (immature neutrophils) reflects state of...

Increased myeloid proliferation (bacterial infections, CML)

4

Important neutrophil chemotactic agents include...

C5a, IL-8, LTB4, kallikrein, platelet-activating factor

5

Which cell type is characterized by a large, kidney-shaped nucleus and extensive "frosted glass" cytoplasm?

Monocyte.

6

Macrophages are activated by...

Gamma-interferon.

7

Lipid A from bacterial LPS binds...on macrophages to initiate septic shock.

CD14

8

...defend against helminthic infections by producing...

Eosinophils; major basic protein

9

Which cell type is characterized by a bilobate nucleus and a cytoplasm packed with large eosinophilic granules of uniform size?

Eosinophils

10

Causes of eosinophilia (hint: NAACP)

1. Neoplasia
2. Asthma
3. Allergic processes
4. Chronic adrenal insufficiency
5. Parasites (invasive)

11

Eosinophils produce...

Histaminase and major basic protein (a helminthotoxin)

12

The densely basophilic granules of basophils contain...

Heparin (anticoagulant) and histamine (vasodilator).

13

Basophils mediate...

Allergic reaction.

14

Basophilia is uncommon, but can be a sign of...

Myeloproliferative disease, particularly CML.

15

Mast cells contain...and originate from the same precursor as...but are not the same cell type.

Basophilic granules; basophils

16

Mast cells can bind...

The Fc portion of IgE to membrane

17

IgE...upon antigen binding, causing..., which releases...

Cross-links; degranulation; histamine, heparin, and eosinophil chemotactic factors

18

Drug used for asthma prophylaxis

Cromolyn sodium -- prevents mast cell degranulation

19

Mast cells mediate...

Type I hypersensitivity reactions in local tissues.

20

Dendritic cells are called...in the skin.

Langerhans cells

21

B cells originate from...and mature in...

Stem cells in bone marrow; marrow

22

When antigen is encountered, B cells differentiate into...

Plasma cells (which produce antibodies) and memory cells.

23

B cells express which CD molecules?

CD19, CD20, CD21

24

T cells originate from..., but mature in...

Stem cells in the bone marrow; the thymus

25

CD molecule that provides a costimulatory signal necessary for T-cell activation.

CD28

26

Which cell type is characterized "clock-face" chromatin distribution, abundant RER, and well-developed Golgi apparatus?

Plasma cell

27

Cancer of plasma cells

Multiple myeloma

28

Universal donors of RBCs

Individuals with type O blood

29

Universal recipients of plasma

Individuals with type O blood

30

Universal recipients of RBCs

Individuals with type AB blood