EXAM #2: ANEMIA IN CHILDHOOD Flashcards Preview

Hematology and Oncology > EXAM #2: ANEMIA IN CHILDHOOD > Flashcards

Flashcards in EXAM #2: ANEMIA IN CHILDHOOD Deck (40)
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1

What is the definition of anemia as it relates to childhood?

Decreased RBC mass

2

What is the consequence of anemia?

Decreased oxygen carrying capacity

3

What labs help to make the diagnosis of anemia in children?

- CBC and PBS
- Hb
- Hct
- Red cell indices
- Reticulocyte count

4

What symptoms are characteristic of anemia in children?

- Fatigue
- Irritability
- Inappropriate behavior

*****Other sx of anemia i.e. decreased exercise tolerance, dyspnea, palpitations...etc. are seen in severe anemia in children.

5

What is the dietary history that is important when evaluating anemia in children?

Milk intake-- children often over consume cow's milk

***** 16-20 ounces is recommended in the toddler*****

6

When is screening for anemia recommended in children?

1) 12 months
2) Kindergarten entrance
3) Adolescents

7

How is the lower limit of MCV calculated in children less than 10?

Age in years + 70

8

How is the upper limit of MCV calculated in children?

84 + 0.6x age in years

9

What is a MCHC greater than 35 g/dL characteristic of?

Spherocytosis

****Mean Corpuscular Hemoglobin Concentration*****

10

When is a low MCHC found?

Iron deficiency anemia

11

What is increased WBC/ low platelets and anemia a sign of?

HUS

(Hemolytic Uremic Syndrome)

12

What can a normal WBC/ low platelet count and mild anemia be a sign of?

ITP

(Idiopathic Thrombocytopenic Purpura)

13

What are the causes of microcytic/ hypochromic anemia in children?

1) Iron deficiency
2) Pb toxicity
3) Thalassemia

14

What are the causes of macrocytic/ hyperchromic anemia?

1) B12 deficiency
2) Folate deficiency

*****Note that a PE exam finding with B12 deficiency that is commonly overlooked is a positive Rhomberg.******

15

What is a common cause of Folate Deficiency in infants?

Infants that are fed goat milk

16

What are the characteristics of Diamond Blackfan anemia?

Normocytic anemia with decreased RC

17

If you see a normocytic anemia and decreased RC count, what should your differential include?

- Diamond Blackfan anemia
- Transient Erythroblastopenia of Childhood
- Parvovirus B19

18

What is a normocytic anemia with increased reticulocytes a sign of?

Blood loss

19

What is a normocytic anemia/ increased RC count with a positive coombs' test indicate of?

Autoimmunity:
1) ABO incompatibility
2) Rh incompatibility

20

What is a normocytic anemia/ increased RC count with a negative coombs' test indicate of?

- Non-immune mediated destruction
- Membrane defect
- Hemoglobinopathy
- G6PD
- Pyruvate Kinase Deficiency

21

When is iron deficiency anemia common in children?

9-24 months

22

What is the common cause of iron deficiency anemia in children?

- Excessive milk intake
- Early milk intake
- Blood loss

23

What are the labs that are indicative of iron deficiency anemia?

- Mild to moderate anemia i.e. Hb (7-10)
- Decreased MCV i.e microcytic
- RDW increased
- Ferretin low
- Transferrin low
- Serum iron low
- TIBC HIGH
- RC normal to increased

24

How is iron deficiency anemia prevented?

- Encourage breast-feeding for more than 6 months
- Iron fortified cereal
- Avoid cow milk under 12 months
- High Fe diet

25

What are the characteristics of TEC?

- Unknown etiology causing transient decrease in RBC production
- Age is greater than 1 year
- Moderate to severe anemia
- MCV is normal i.e. normocytic
- Reticulocyte count is decreased

26

What are the characteristics of Diamond Blackfan anemia?

- Under 1 year of age
- Moderate to severe anemia
- RC decreased
- HgB F increased
- 25% have physical abnormalities

27

What causes of Diamond Blackfan anemia?

Abnormal ribosomal protein synthesis

****Don't make precursor cells*****

28

What is the treatment of TEC?

- Supportive
- Transfuse if unstable

Spontaneous recovery usually happens within a year

29

What is the treatment for DBA?

- Prednisone
- Transfusion
- Bone marrow transplant IF resistant to steroids

30

How is iron deficiency treated?

6mg/kg/day of oral elemental iron until Hb is normal + 2 more months