fri jul 31 Flashcards
(31 cards)
clopidogrel MOA
irreversibly blocks the PY12 component of ADP receptors- prevents aggregation
what alternate antiplatelet agent do you give someone with aspirin sensitivity?
clopidegrel
cilostazol MOA
PDE inhibitor
eptifibatide MOA
platelet glycoprotein IIb/IIIa inhibitor-blocks platelet aggregation
during an acid fast stain, what does carbofuscin bind to?
mycolic acid -holds onto the colour in the following steps of hydrocloric acid and alcohol
naproxen MOA
reversibly inhibits COX1 and COX2
pathogenesis of bloom syndrome?
mutation in BLM - dysfunctional helicase - chromosomal instability and breakage
presentation of bloom syndrome?
growth retardation, face anomalies, photosensitive rash and immunodeficiency
what are the three stages of acute tubular necrosis? (and timelines)
- Initiation (24-36 hours)
- Maintenance (1-3 weeks)
- Recovery phase (months)
what is the initiation stage of acute tubular necrosis?
Injury from ischemia or cytotoxins
what are the findings in the maintenance phase of acute tubular necrosis?
- oliguric renal failure (decreased GFR, decreased urine output, fluid overload)
- increased creatine/BUN, increased potassium and metabolic acidosis
what are the findings in the recovery phase of acute tubular necrosis?
- gradual increase in urine output, leading to high volume diuresis
- continued impairment of renal tubular function, resolving in electrolyte wasting (decreased potassium magnesium, phosphorous, calcium)
what is the most common viral oppurtunistic infection of the GI tract in AIDs patients?
CMV
Presentation of CMV colitis
fever, aorexia, weight loss, abdominal pain.
colonoscopy findings of CMV colitis?
mucosal erythemia, erosions, ulcerations
histological findings of CMV colitis?
acute and chronic inflammation. Vasculitis, giant cells with larve, ovoid nuclei with basophilic cytoplasmic inclusions
cryptosporium effects which part of the GI tract?
small intestine
brain findings of normal pressure hydrocephalus?
enlarged ventricles
what is diltiazem and verapamil?
non-dihydropyridine Ca blockers
GI side effect of non-dihydropyridine Ca blockers?
constipation
what is an incidactor that erectile dysfunction is psychogenic?
normal erections at night time or during masturbation
lisdexamfetamine use?
Binge-eating disorders (overeating - not bulimia
what is acute dystonia?
sudden, involutnarly contraction of a muscle or muscle group (ex. cocked head)
naltrexone MOA
blocks mu opioid receptor
