mon 24

Question 1

membranous nephropathy may be caused by antibodies to which substance?

Answer 1

phospholipase A2 receptor (expressed on podocytes)

Question 2

what is the immunofluorescence pattern seen in membranous nephropathy?

Answer 2

granular due to immune complex deposition

Question 3

what is the EM pattern seen on membranous nephropathy?

Answer 3

spike and dome

Question 4

what causes the mesangial expainsion in diabetic glomerulonephropathy?

Answer 4

nonenzymatic glycation of tissue proteins

Question 5

diffuse proliferative glomerulonephritis is often due to which disease?

Answer 5

SLE

Question 6

what will b seen on LM or diffuse proliferative glomerulonephritis?

Answer 6

wire looping

Question 7

inheritance of alport syndrome?

Answer 7

x linked

Question 8

type II membranoproliferative glomerulonephritis will have which igG autoantibody?

Answer 8

C3 nephritic factor - stabilizes C3 convertase

Question 9

why does imatinib help treat GIST?

Answer 9

it ALSO blocks c-kit tyrosine kinase

Question 10

what does erlotinib block?

Answer 10

EGFR

Question 11

erlotinib A/E?

Answer 11

diarrhea and acneiform rash

Question 12

what do sunitinib and sorafenib inhibit?

Answer 12

VEGFR overexpresison

Question 13

what does vemurafenib inhibit?

Answer 13

B-raf (BRAF)

Question 14

what cancer commonly has a V600E BRAF mutation?

Answer 14

malignant melanoma

Question 15

what does bevacuzimab target?

Answer 15

VEGF

Question 16

what kind of drugs are carmustine and lomustine?

Answer 16

nitrosureas

Question 17

how does valproic acid affect weight?

Answer 17

weight gain

Question 18

how does topiramate affect weight?

Answer 18

weight loss

Question 19

side effects of lamotrigine?

Answer 19

diplopia, SJS

Question 20

which antiseizure drug is associated with gingival hypertrophy?

Answer 20

phenytoin

Question 21

which antiseizure drug is associated with hirsutism?

Answer 21

phenytoin

Question 22

which antiseizure drug is associated with SIADH?

Answer 22

carbamazepine

Question 23

gabapentin MOA?

Answer 23

blocks Ca channels

Question 24

MOA of ethosuxamide?

Answer 24

blocks T type Ca channels in thalamus

Question 25

which seizure drug may cause acute closed angle glaucoma?

Answer 25

topiramate

Question 26

carbamazepine MOA?

Answer 26

increases Na channel inactivation

Question 27

A/E of carbemapazine?

Answer 27

- SIADH - agranulocytosis - DRESS syndrome - SJS

Question 28

phenytoin MOA?

Answer 28

increases Na channel inactivation

Question 29

effects of phenytoin and carbamazepine on CYP 450s?

Answer 29

inducers

Question 30

gabapentin MOA

Answer 30

blocks voltage gated Ca channels

Question 31

what is primidone?

Answer 31

barbituate

Question 32

effects of V1 activation?

Answer 32

vasoconstrictino

Question 33

what type of receptor is V1?

Answer 33

Gq

Question 34

what type of receptor is V2?

Answer 34

Gs

Question 35

where are V2 receptors found?

Answer 35

the collecting duct

Question 36

how does administering desmopressin help treat esophageal varicies?

Answer 36

it causes vasoconstriction -> reduced bleeding

Question 37

MOA of the 'vaptan' drugs?

Answer 37

BLOCK V2 receptors- treat SIADH

Question 38

demeclocycline use?

Answer 38

treats SIADH