Helicobacter-Psuedomonas-Bordetella-Corynebacterium Flashcards
(45 cards)
What shape and gram stain is helicobacter pylori?
Gram - vibrio
The following are virulence factors of \_\_\_\_\_\_: Urease VacA CagA Mucinase Flagella
Helicobacter pylori
____: protein acts on gastric mucosal epithelia and promotes flow of urea into stomach; virulence factor of Helicobacter pylori
VacA
_____ protein: injected into host epithelia cells change (prelude to cancer); virulence factor of Helicobacter pylori
CagA
_____: degrades mucus later for bacterial invasion;virulence factor of Helicobacter pylori
Mucinase
_____: (urea ->ammonia ->pH increase, neutralization of stomach acid); virulence factor of Helicobacter pylori
urease
Initial infection induces a low grade immune response with IgM, followed by IgA and IgG production.
This suppresses bacterial growth and leads to the typical low-level persistent infection which remains symptom-free for 80-90% of carriers
Gastric ulcer
For a _____, there is no proven preventative measure. Most infections cured by 2 antibiotics together plus a med to suppress stomach acid
Gastric ulcer
Organisms survive the acidity of stomach juices by producing a powerful ______
Urease
Upon reaching the later of mucus, the bacteria penetrate to the epithelial surface where bacterial products incite an ____ response
Inflammatory response
Once the mucus layer is thinned, between ____ and ____ % of infected individuals develop ulcers
10-20%
What bacteria is the most common associated bacteria with gastric ulcers?
Helicobacter pylori
Does H. pylori confer antibiotic resistance?
Yes
Are most people infected with H pylori symptomatic or asymptomatic?
Asympomatic
Gram− short rods polar flagella(one or more; high mobility) obligate aerobe simple nutrient requirements (acetate) broad temperature range: 20 to 43 ºC
Pseudomonas aeruginosa
What is the gram stain and shape of Pseudomonas aeruginosa?
Gram - rods
What is the O2 requirements of Pseudomonas aeruginosa?
Obligate aerobes
The following virulence factors are characteristic of \_\_\_\_\_: Pili Flagellum Siderophores Pyocyanin Exotoxin A Alginate Capsule LPS
Pseudomonas aeruginosa
____ is a virulence factor of Pseudomonas aeruginosa used for adherence, protection from dehydration, and immune evasion; helps to form biofilm
Alginate
____ is a virulence factor of Pseudomonas aeruginosa used for endotoxicity, core interacts with CFTR; protects from complement-mediated killing
LPS
_____ is opportunistic pathogen(in case of disease, cancer, weakened immunity):
1.common in environment (water, soil)
+ Hot tubs are perfect culture conditions (due to heat tolerance)
2.resistance to many chemical desinfectants (like iodine)
3.R-plasmid based resistance to many antibiotics
Pseudomonas aeruginosa
major problem in hospitals (nosocomial infections)
- lungs: artificial ventilators, cystic fibrosis(mucoid strains)
- skin: burn victims, folliculitis
- bladder infections
- ear infections (swimmer’s ear: otitis externa)
- eye infections (from contact lenses)
Pseudomonas aeruginosa
Soluble blue-green dye _____ and ______ characterize P.aeriginosa
pyocyanin and pyoverdin
_____ is usually a nosocomial infection and clinically seen in pulmonary conditions like CF patients
Pseudomonas aeruginosa
