Immunology 1

Question 1

resistance to infectious disease

Answer 1

Immunity:

Question 2

collection of cells, tissues, and molecules that mediate resistance to infections

Answer 2

Immune system:

Question 3

coordinated reaction of the immune system to infectious microbes

Answer 3

Immune response:

Question 4

: study of the immune system, including its responses to microbial pathogens and damaged tissues and its role in disease

Answer 4

Immunology

Question 5

Which branch of the immune system involves the epithelial barriers, mast cells, phagocytes, dendritic cells, complement, and NK cells and ILGs?

Answer 5

Innate immunity

Question 6

Which branch of the immune system involves B and T cells?

Answer 6

Adaptive immunity

Question 7

• Acts immediately or within hours.
• Is not antigen specific. Instead, recognizes “Pathogen-associated molecular patterns” (PAMPs)that are shared by many different microbes, and Damage-associated molecular patterns (DAMPs).
• Genes encoding receptors that recognize PAMPs are present in the germ line.
• They do not undergo somatic recombination or hyper mutation.
• No clonal expansion of cells of innate immune system in response to infection.
• Nonreactive to self.
• No memory.

Answer 7

Innate immunity

Question 8

• Requires days to weeks before it is effective.
• Is highly antigen-specific. Recognizes specific epitopes on specific proteins of specific pathogens.
• Functional genes encoding antigen receptors are notpresent in the germ line.Instead, functional antigen receptor genes are generated by somatic recombination and mutation of germ line genes during maturation of B cells and T cells (prior to exposure to any antigens).
• Clonal selection and proliferation of B and T lymphocytes specific for particular antigens following exposure to those antigens.
• Nonreactive to self.
• Gives rise to immunologic : memory”

Answer 8

Adaptive immunity

Question 9

___.-response of Adaptive Immune system involves Antibodies produced by B cells

Answer 9

Humoral response

Question 10

___.-response of Adaptive Immune system involves Cytotoxic T cells (CTLs) and Helper T cells

Answer 10

Cell mediated response

Question 11

Which immunity of adaptive immune system is recognizes mostly protein antigens?

Answer 11

Cell mediated immunity

Question 12

Which immunity of adaptive immune system functions to block infections and eliminate extracellular microbes?

Answer 12

Humoral immunity

Question 13

Which immunity of adaptive immune system functions to eliminate phagocytosed microbes and kills infected cells and eliminates reservoirs of infection?

Answer 13

Cell mediated immunity

Question 14

What feature of adaptive immunity ensures that distinct antigens elicit specific responses?

Answer 14

Specificity

Question 15

What feature of adaptive immunity enables immune system to respond to a large variety of antigens?

Answer 15

Diversity

Question 16

What feature of adaptive immunity increases number of antigen-specific lymphocytes from a small number of naive lymphocytes?

Answer 16

Clonal expansion

Question 17

What feature of adaptive immunity leads to enhanced responses to repeated exposures to the same antigens?

Answer 17

Memory

Question 18

What feature of adaptive immunity generates responses that are optimal for defense against different types of microbes?

Answer 18

Specialization

Question 19

What 2 features of adaptive immunity allow immune system to respond to newly encountered antigens?

Answer 19

Contraction and homeostasis

Question 20

What feature of adaptive immunity prevents injury to the host during responses to foreign antigens?

Answer 20

Nonreactivity to self

Question 21

______: mediators of humoral immunity

Answer 21

B lymphocytes

Question 22

______: mediators of cell-mediated immunity

Answer 22

T lymphocytes

Question 23

______: APC involved in initiation of T cell response

Answer 23

Dendritic cells

Question 24

______: APC involved in effector phase of cell-mediated immunity

Answer 24

macrophage

Question 25

______: APC involved in display of antigens to B lymphocytes in humoral immune responses

Answer 25

Follicular dendritic cells

Question 26

______: effector cells involved in activation of phagocytes, killing infected cells

Answer 26

T lymphocytes

Question 27

______: effector cells involved in phagocytosis and killing of microbes

Answer 27

Macrophages

Question 28

______: effector cells involved in killing microbes

Answer 28

Granulocytes

Question 29

______: lymphocytes are involved in neutralization of microbe, phagocytosis, and complement activation

Answer 29

B lymphocytes

Question 30

______: lymphocytes are involved in activation of macrophages, inflammation, and activation (proliferation and differentiation) of T and B lymphocytes

Answer 30

Helper t lymphocytes

Question 31

______: lymphocytes are involved in killing of infected cell

Answer 31

Cytotoxic T lymphocyte

Question 32

______: lymphocytes are involved in suppression of immune response

Answer 32

Regulatory T lymphocyte

Question 33

After lymphocytes activated by antigen, B & T cells migrate towards each other & meet at _____ of ______

Answer 33

edge of follicle.

Question 34

At edge of follicle, ______ cells interact with and help B cells differentiate into antibody producing cells.

Answer 34

helper T cells