MOD 3 - COURSE 3 - BIOLOGY OF SPECIES SPECIFIC FEATURES - PT 1 - MICE Flashcards

(31 cards)

1
Q

WHY DO WE USE MICE

A

-inexpensive
- easy to maintain
- efficient breeders
- reproduce quickly

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2
Q

whats malocclusion?

A

oconditions where upper and lower incisors = not properly aligned - so the teeth dont wear down naturally when they eat

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3
Q

what health problems can be caused by malocclusion

A
  • facial abscesses
  • weight loss
  • death
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4
Q

what teeth do mice have

A

one pair lower and upper incisors
1/1 0/0 0/0 3/3 - one incisor, 3 molars and no canines or premolars per quandrant (dental formular)

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5
Q

mice cannot vomit True or false?

A

true - lack neural pathways - connecting oesophagus at stomach - prevents regurgitation

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6
Q

what does the small size of the mice mean?

A
  • high metabolic rate so high drug clearance
  • large SA of body so can be vulnerable to hypothermia
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7
Q

do mice have sweat glands

A

none apart from foot pad

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8
Q

what is a mouses halftime turn over of water?

A

1.1 days

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9
Q

how do you tell the difference between males or females

A

the distance between anus and urogenital opening = greater for males than females

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10
Q

female mice are polyestrous - what does this mean

A

more than one oestrous cycle - heat per year

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11
Q

when does a mice become sexually mature

A

40-60 days

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12
Q

how long is the oestrous cycle of a mice

A

4-5 days and 24 hours post partum

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13
Q

how long is the gestation period of mice

A
  • 19-21 days
  • gestation = time between conception and birth
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14
Q

whqat is the normal litter size of mice

A

6-12

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15
Q

how long do the mice pups wean for?

A

21 days
- no longer dependend on mothers milk after 21 days

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16
Q

what can be used as a sign of successful mating between female and male mice

A
  • mucous plug in female vagina - 24 hours
17
Q

is mating between micr polygamous or monogamous or both?

A

both (can be 1 male : 1 female or 1 male : many females)

18
Q

what is the body weight of adult, weanling and newborn mice

A

25-40g
10-15g
~1g

19
Q

what is normal mice body temp

A

36.4’C-38’C

20
Q

what is the normal HR of mice

21
Q

what is respiration rate of mice

22
Q

what is the daily food and water intake of mice?

23
Q

what is the normal life span of mice

24
Q

what does outbred stock mean

A

colony of lab aniamls within which there is some genetic variation which has been closed for at least 4 generation

25
what are some outbred characteristics of mice
- good reproductive performance - mainrained through random breeding - large litter size - each individual = genetically unique - heterozygous animal - genetically and phenotypically variable - characteristics of colonies can quickly change
26
what are some example strains of outbred stock of mice
- CF1 - CD1 - Swiss Webster SW
27
what does inbred strain mean
- colony of genetically identical individuals
28
what are some characteristics of inbred strains
- homozygous at virtually all genes - genetic and phenotypic uniformity - long term stability - as only way they can change is mutation - due to homozygousity - some deleterious recesive genes = become fixed within each strain leading to inbreeding depression than can result in poor breeding - each isogenic strain = unique with its own specific set of characteristics
29
what are some examples of inbred strains of mice
C57BL/6, DBA, BALB/c
30
What are some normal behaviour of mice?
- noctournal - constant grooming - agression can differ per strain - nest building - social animals - form stable bredding froups - demes - formation of hierarchies among male and female
31
what are some abnormal behaviours of mice
- barbering ~(wisker/hair pulling), - sterotypic behaviours - repititive pointless behvaiour - captive animal - prevelance varies by strian but often seen in lab mice with no enrichement