Movement Disorder Drugs Mechanisms Flashcards Preview

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Flashcards in Movement Disorder Drugs Mechanisms Deck (12):
1

Overall, what are the class of drugs used to treat Parkinsons

-Dopamine agonists or anticholinergic

2

What is the mechanism of Levodopa

Aka L-Dopa and acts at the dopamine receptors

3

What disorder is levodopa used to treat

Parkinsons

4

How is levodopa absorbed and get into CNS

Absorbed in the small intestine, and enters the CNS via the L amino acid transporter (LAT)

5

What is the mechanism of carbadopa

DOPA decarboxylase inhibitor

6

What are the side effects in the GI during Levodopa administration

Anorexia, nausea, vomiting (can all be reduced with coadministration of carbidopa)

7

What are the CV effects during administration of Levodopa

Postural hypotension
-Hypertension if given with MAO inhibators

8

What are the movements seen with administration of Levodopa

Choreoathetosis (intermediate speed movements) in the face and distal extremities

9

When giving levodopa, what class of drugs is contraindicated due to a CV reason

MAO inhibators

10

When giving levodopa, what class of drugs is contraindicated due to a eye problems

Contraindicated in glaucoma patietns

11

What is the mechanism that Catechol-O-methyltransferase (COMT) inhibitors work

Inhibits the breakdown of levedopa

12

What is the function of COMT

Metabolizes levodopa to 3-O0methyldopa, which then competes with levodopa