Respiratory Drugs-antifungals Flashcards Preview

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Flashcards in Respiratory Drugs-antifungals Deck (18):
1

What is the treatment for Aspergillus

Voriconazole

2

What form is posaconazole available for

Liquid oral

3

Which fungi targeted with intraconazole

Dimorphic such as histo, blasto, sporothrix

4

Adverse effect of ketoconazole

Interacts with human P450

5

What is the permeability if fluconazole into CSF

Good penetration

6

Elimination of azoles are where

All hepatic except fluconazole which is renal

7

Adverse affects of flucytosine

Blood based issues (anemia, leukopenia, thrombocytopenia

8

Site of action for amp B

Membrane function

9

What is the permeability of intraconazole

Poor penetration into CSF

10

Drug for esophageal candidiasis or candidemia

Anidulafungin

11

MOA of echinocandins

Inhibits glucan synthase

12

MOA for flucytosine

Converted to product that inhibits RNA and DNA synthesis

13

What is the treatment for mucormycosis

Posaconazole

14

Site of action for azoles

Ergosterol synthesis

15

What are the adverse effects of voriconazole

Inhibits CYP3A4
Visual disturbances

16

Site of action for echinocandins

Cell wall synthesis

17

Administration form of echinocandins

IV only

18

What is posaconazole used for

-Salvage of invasive aspergillosis
-prophylaxis in chemo for leukemia
-allogenic bone marrow transplants with graft versus host