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Renal- Male GU Pharm Flashcards

(64 cards)

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1
Q

What is the result of using alprostadil

A

Prostaglandin E1 that is injected into the penis

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2
Q

What class of drug is avanafil

A

PDE-5 Inhibitor

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3
Q

What is the specificity for alfuzosin

A

Non selective alpha 1

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4
Q

What is the specificity for silodosin

A

Alpha1A = Alpha1D >alpha 1 B

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5
Q

What class of drug is dutasteride

A

Steroid 5alpha reductase inhibitor

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6
Q

What are the adverse effects of terazosin

A

Postural hypotension, dizziness, fatigue

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7
Q

Which class of drug is doxazosin

A

Alpha 1 adrenergic receptor antagonist

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8
Q

What is the function of PDE-5

A

Decreases the amount of cAMP, which increases the amount of calcium and smooth muscle contraction, resulting in less of an erection

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9
Q

Which class of drug is alfuzosin

A

Alpha 1 adrenergic receptor antagonist

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10
Q

What is the fastest acting PDE-5 inhibitors

A

Avanafil

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11
Q

What is the time period of treatment for dutasteride

A

3-6 months

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12
Q

What class of drug is vardenafil

A

PDE-5 Inhibitor

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13
Q

What class of drug is tadalafil

A

PDE-5 inhibitor

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14
Q

Which class of drug is silodosin

A

Alpha 1 adrenergic receptor antagonist

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15
Q

Which class of drug is terazsin

A

Alpha 1 adrenergic receptor antagonist

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16
Q

What are the drug interactions for alfuzosin

A

PDE 5 inhibitors (Sildenafil, vardenafil)

Increased CYP3A4 substrates

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17
Q

What is the target for finasteride

A

Specific inhibitor of SAR2, which is a steroid 5 alpha reductase

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18
Q

What class of drug is tadalafil

A

PDE-5 Inhibitor

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19
Q

What is the uroselectivity of terazosin

A

None

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20
Q

What are the contraindications specific for sildenafil

A

Concurrent alpha blockers initiated at lowest recommended dose

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21
Q

What are the drug interactions of tamsulosin

A

PDE 5 inhibitors (Sildenafil, vardenafil)

Increased CYP3A4 substrates

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22
Q

What class of drug is sildenafil

A

PDE-5 Inhibitor

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23
Q

What conditions are tadalafil used for

A

BPH and ED

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24
Q

What is the time period for treatment in finasteride

A

3-6 months

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25
What are the drug interactions for silodosin
PDE 5 inhibitors (Sildenafil, vardenafil) | Increased CYP3A4 substrates
26
Which patient conditions should be avoided with alfuzosin
Avoid hepatic impairment
27
What is the mechanism of action for alprostadil
-Acts lie PGE1, which increases the activity of adenylate cyclase. This will increases the amount of cAMP, decrease the amount of calcium, and increases the amount of muscle relaxation that results in erection
28
What are the adverse effects specific to tadalifil
Back pain, myalgia, limb pain
29
What is the location of SAR 1 and 2
SAR1 - serum | SAR2- Prostate
30
What class of drug is finasteride
Steroid 5 alpha reductase inhibitor
31
What is the result when the GU system is antagonized with alpha 1 antagonists
-Reduces spasms, promotes muscle relaxation and improved urine flow
32
What is the specificity for doxazosin
Alpha 1
33
What are the drug interactions for terazosin
PDE5 inhibitors (sildenafil, vardenafil)
34
What is the mechanism of action for steroid 5alpha reductase inhibitors
Prevents enlargement and shrinks the prostate by blocking 5 alpha reductase, which converts T to DHT
35
What is the metabolism mechanism for PDE-5 Inhibitor
CYP3A4
36
What are the drug interactions for doxazosin
PDE5 inhibitors (sildenafil, vardenafil)
37
What is the longest lasting PDE-5 Inhibitor
Tadalafil (36 hours)
38
What are the adverse effects of doxazosin
Postural hypotension, dizziness, fatigue
39
What is the adverse effects of silodosin
Reduced ejaculation, IFIS
40
What is the time period for effect with an alpha 1 adrenergic antagonist
Rapid relief of symptoms (days)
41
What is the overall result of GU system when alpha 1 receptors are agonized by NE
- Muscle contraction and bladder outlet obstruction | - Detrusor instability
42
What is the adverse effects of tamsulosin
Reduced ejaculation, IFIS
43
How is avanafil different from the other PDE-5 inhibitors with regards to timing
Can be taken high does 15 minutes before or normal dose 30 minutes before. All the others need an hour
44
What is the target for dutasteride
Nonspecific inhibitor of SAR 1 and 2, which are steroid alpha 5 reductases
45
What is the adrenergic receptors in the Spinal cord and what is the function
Alpha 1D, and gives control of urinary function
46
Which is the drug that will be effective in treating BPH and ED
Tadalafil
47
Which drug will result in a larger decreased in the amount of serum DHT
Dutasteride (dual inhibitor)
48
What are the adverse effects of alfuzosin
QT prolongation
49
What is the uroselectivity of silodosin
Specificity alpha a1A=a1D
50
What are the contraindications of vardenafil
Needs to be hemodynamically stable
51
What is the uroselectivity of tamsulosin
Specificity, alpha 1A=alpha AD
52
What is the adrenergic receptor in the prostate and what is the result
Alpha 1A which causes smooth muscle contraction
53
What is the overall serum levels as a result of steroid 5 alpha reductase inhibitors
-Decreased DHT -Decreased PSA Increased testosterone Decreased DHT
54
What are the contraindications for tadalafil
When used for BPH, concurrent alpha 1 blockers not recommended
55
What is the adrenergic receptor in the detrusor muscle
Alpha 1D > alpha1A
56
What is the uroselectivity of doxazosin
None
57
What are the contraindications for PDE-5 Inhibitors
-Organic nitrates, leading to dangerous hypotension
58
What are the adverse effects of alprostadil
Prolonged erection (priapism) that leads to clogged blood, but can result in fibrosis and ED
59
What is the specificity for tamsulosin
Alpha1A = Alpha1D >alpha 1 B
60
Which class of drug is tamsulosin
Alpha 1 adrenergic receptor antagonist
61
What is the uroselectivity of alfuzosin
Very function and selective, as collects in the urine
62
What is the drug class of alprostadil
Prostaglandin E1
63
What is the common clinal side effects seen with PDE-5 Inhibitor
Blue/burred vision due to nonspecific binding to PDE-6
64
What is the specificity for terazosin
Alpha 1

Pharmacology & Drugs (43 decks)

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