Neuro-Narcotic Analgesics Flashcards Preview

Pharmacology & Drugs > Neuro-Narcotic Analgesics > Flashcards

Flashcards in Neuro-Narcotic Analgesics Deck (36):
1

What is the classification for the opioid oxymorphone

Semisynthetic full agonist

2

What are some of the acute affects of opioid use

-Respiratory depression, urticaria (skin rash), pruritus (urge to scratch), myoclonus and seizures

3

What is the classification for the opioid buprenorphine

Partial mu-R agonist

4

What are effects of long term chronic opioid use

Hypogonadism, immunosupression, increased feeding and GH secretion, hyperalgesia

5

What is the only opiod with a low efficacy

Codeine

6

What are the general trends seen in administration of opioids in the altered physiological state of infants

Prolonged effect (immature renal function and decreased conjugating ability)

7

What are the general trends seen in administration of opioids in the altered physiological state of obesity

Overdosage (Vd is not represented by the body weight)

8

What is the mechansim of action for Tapentadol

NET inhibator and moderate Mu-R agonist

9

What are the general trends seen in administration of opioids in the altered physiological state of renal failure

Morphine toxicity (accumulation of M6P)
Pethidine toxicity (accumulation of norpethidine)

10

What is the classification for the opioid hydromorphone

Semisynthetic full agonist

11

What is the mechanism of action for post synaptic mu receptors

Increases potassium efflux and subsequent hyperpolarization

12

What is nalmefene used to treat

Alcohol addiction by antagonist of Mu-R and partial agonist of Kappa

13

What is the classification for the opioid codeine

Natural full agonist

14

What is the classification for the opioid alfentanil

Synthetic full agonist

15

Which opioids can be used as an antitissive

-Codeine
-Dextropethorphan
-Levopropoxyphene

16

What is the mechanism of tramadol

Strong SERT inhibitor, weak NET inhibitor

17

What is the classification for the opioid pethidine

Synthetic full agonist

18

What are the general trends seen in administration of opioids in the altered physiological state of hepatic failure.

Increased sensitivity (altered BBB if with encephalopathy, along with increased half life due to decreased detoxifying ability

19

What are the 4 opioid mixed receptor agonist antagonists

-Pentazocine
-Nalbuphine
-Buprenorphine
-Butorphanol

20

What is the classification for the opioid methadone

Synthetic full agonist

21

What are the contraindications for used of opioids

-Respiratory depression
-Renal Failure
-biliary colic
-blood toxicity
-Raised intracranial pressure

22

What is the classification for the opioid fentanyl

Synthetic full agonist

23

What is the classification for the opioid Morphine

Natural full agonist

24

What is methadone used to treat and what is the mechanism

Opioid addictions via agonist of Mu-R

25

What are the MOA for Buprenorphine

Partial mu agonist and kappa antagonist

26

What is the MOA for Nalbuphine

Kappa agonist and mu antagonist

27

What is the classification for the opioid tramadol

Synthetic full agonist

28

Which of the opioids are influenced by the first pass system

-Morphine
-Methadone
-Fentanyl

29

What are the medium strength opioids

-Nalbuphine
-Pentazocine
-Buprenorphine

30

What is the classification for the opioid remifentanil

Synthetic full agonist

31

What are the general trends seen in administration of opioids in the altered physiological state of elderly

INcreaed sensitivity and prolonged effect (increase fat mass and detoxifying ability)

32

What is the mechanism of action for opioids in the Presynaptic mu receptor

Inhibits calcium influx and decreased NT release

33

What is naltrexone used to treat

Alcohol and opioid addiction via antagonist of Mu-R and partial agonist of kappa

34

What is the classification for the opioid pentazocine

Agonist-antagonist

35

What is the classification for the opioid Naltrexone

Mu-R antagonist

36

What is buprenorphine used to treat

Opioid addiction via partial agonist of all three receptors