Neuro-Metronidazole Flashcards Preview

Pharmacology & Drugs > Neuro-Metronidazole > Flashcards

Flashcards in Neuro-Metronidazole Deck (6):
1

What kind of drug is Metronidazole

Prodrug

2

How is Mitronidazole and 5-Nitroimidazoles activated

Activation by the susceptible anaerobic pathogens

3

What are the targets of mitronidazole and 5-nitromidazoles

Anaerobic bacteria and protozoan

4

What is the mechanism of action for mitronidazole and 5-nitroimidazoles

An electron from the ETC is loaded onto the drug, which then creates a reactive ion that does DNA damage

5

What is a mechanism of resistance against metronidazole and 5-nitroimidazoles

Increased production of O2 (competes with drug)

6

What are the side effects of mitronidazole

-Metallic taste in mouth
-Disulfiram effect (vomiting if taken with alcohol)