Quiz 3 Adrenals Flashcards Preview

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Flashcards in Quiz 3 Adrenals Deck (22):
1

What are the 3 zones of the adrenal cortex what does each secrete?

zona glomerulosa: mineralcorticoids (aldosterone)
zona fasciculata: glucocorticoids (cortisol)
zona reticularis: sex hormones (DHEA)

2

what does the adrenal medulla secrete?

NE/Epi/Dopamine

3

#1 cause of primary hyperaldosteronism/Conn's syndrome?

functional adrenal adenoma

4

HTN + unexplained hypokalemia and hypernatremia, high serum aldosterone, decreased plasma renin

primary hyperaldosteronism/Conn's syndrome

5

#1 iatrogenic cause of Cushing's

glucocorticoid use

6

#1 non-iatrogenic cause of Cushing's

tumors in pituitary (cushing dz) tumors in adrenal gland (cushing syndrome)

7

#1 cause of primary Addison's disease

autoimmune disease of adrenal cortex

8

Primary Addison's pigmentation

high ACTH leads to hyperpigmentation

9

#1 cause of secondary Addison's disease

Inadequate secretion of ACTH by anterior pituitary

10

Secondary Addison's pigmentation

low ACTH leads to no hyperpigmentation

11

Which type of Addison's has high ACTH?

primary

12

What can happen with withdrawal of long-term exogenous corticosteroid use?

Addisonian crisis

13

Adrenal gland failure due to hemorrhage into adrenal glands

Waterhouse-Fredrickson syndrome

14

#1 bacterial cause of Waterhouse-Fredrickson sydrome

Miningococcus (neisseria meningitidis)

15

#1 cause of congenital adrenal hyperplasia due to

21-hydroxylase deficiency

16

what labs are elevated in 21 hydroxyls deficiency

17 ketosteroids
17 hydroxyprogesterone

17

#1 pathology associated with adrenal medulla

pheochromocytoma

18

Catecholemine secreting tumor of chromatin cells within adrenal medulla

pheochromocytoma

19

#1 solid extra-cranial malignancy in infants and children

neuroblastoma

20

tumor of neural crest cells, usually arise form adrenal glands but can be located anywhere on sympathetic chain

neuroblastoma

21

Rosettes (circular groupings of dark tumor cells surrounding a pale center of neurofibrils)

neuroblastoma

22

Rosettes are found in?

neuroblastoma, medulloblastoma, retinoblastoma