Flashcards in Quiz 3 Parathyroid Deck (19):
light to dark pink, eosinophilic, polygonal, central, round nucleus contains secretory granules
what do chief cells located in parathyroid gland secrete?
what type of cells are few in number, smaller nuclei.
oxyphil cells (don't know what they secrete)
What hormone decreases serum calcium?
what cells secrete calcitonin?
parafollicular cells of thyroid gland
PTH1 receptors are where?
bone and kidney
PTH effects kidneys how?
increases renal tubular Ca reabsorption and phosphate excretion
converts vit D to active form
how does PTH effect bone?
increase Ca and phosphate reabsorption in intestine Ca
how does vit D effect Ca?
increases serum Ca and PO4 reabsorption in intestine
#1 cause of primary hyperparathyroid outpatient and overall
#1 cause of primary hyperparthyroid inpatient?
single mass in parathyroid gland, identical appearing cell population, no adipose tissue, no mitotic figures
#1 cause of secondary hyperparathyroid
reduced adipose tissue in parathyroid gland, but all cell types still present
primary hyperplasia (seen in secondary hyperparthyroid due to renal failure)
abrupt onset of hypercalcemic related symptoms (bone pain, renal stones)
nests of neoplastic cells, not pleomorphic, with bands of fibrous stroma in between
#1 cause of hypercalcemia of malignancy
ectopic production of PTHrP by CA cells
#2 most common CA that produces PTHrP
breast and lung