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Flashcards in Quiz 3 Pancreas Deck (23):
1

light staining spherical clusters that produce hormones

islet of Langerhans

2

alpha cells secrete

glucagon

3

beta cells secrete

insulin and amylin

4

delta cells secrete

somatostatin

5

enterochromaffin cells secrete

serotonin

6

insulin effects on islet cells

activates beta cells and inhibits alpha cells

7

glucagon effects on islet cells

activates alpha cells and then alpha cells activate delta cells

8

somatostatin effect on islet cells

inhibits alpha and beta cells

9

#1 type of primary DM

DM2 (85-95%)

10

#2 type of DM

DM1 (5-10%)

11

#3 type of DM

DM1.5 (5%)

12

Autoimmune disease with islet destruction by immune cells reacting to endogenous b-cell antigens

Type 1 DM

13

antibodies to DM1

anti-islet cell Ab
anti-insulin Ab

14

Presence of lymphocytic infiltrates in the islets of Langerhan suggests what?

suggests autoimmune mechanism (DM1)

15

Insulin resistance and decreased production of insulin by B cells

DM2

16

Pink hyalinization and amyloid deposition in the islets of langerhans

DM2

17

#1 cause of vision loss due to retinopathy

diabetic retinopathy

18

dilated capillaries, micro aneurism lead to leaked RBC leads to retinal hemorrhage, edema, exudate

non-proliferative diabetic retinopathy

19

lack of oxygen to retina leads to development of fragile new blood vessels that lead to retinal detachment

proliferative diabetic retinopathy

20

earliest detectable change is thickening of capillaries within glomeruls, then nodular glomerulosclerosis

diabetic retinopathy

21

pacreatic tumor derived from beta cells that secretes gastrin and leads to excess HCL and ulcerations

gastrinoma

22

#1 location of gastrinoma

duodenum

23

triad of gastric acid hyper secretion, severe peptic ulceration, and gastrinomas of pancreas or duodenum

Zollinger-Ellison Syndrome