Flashcards in Quiz 4 Bone Deck (50):
softening of bone
dense or hardening bone
brittle bone disease
Osteogenesis imperfect is defective connective tissue due to what?
deficiency in normal type 1 collagen which forms bone matrix
idiopathic avascular osteonecrosis of epiphysis of femoral head leading to interruption of blood supply to head of femur
legg calve perthes syndrome or avascular necrosis
osteomalacia in children is called what and due to what deficiency?
In children under 4 who have Rickets what do you see?
In chidlren over 4 what do you see?
under 4 = leg bowing = genu varum
over 4 = knock knees (genu valgum)
what does x-ray of rickets pt show?
rackitic rosary/beading of ribs of costochondral joints
secondary osteoporosis is caused by what?
CA, endocrine, drugs, malabsorption
Are osteoclasts or blasts more active in osteoporosis
Clasts because they are breaking down bone.
What is most common sequelae of osteoporosis and location?
fracture of vertebrae
overactivity of osteoclasts and osteoblasts with multiple bones being affected?
hist of Paget's
mosaic pattern of lamellar bone (jigsaw)
x-ray of skull with Paget's
What is unique about Page'ts fracture?
straight line across
what labs are elevated in Pagets?
what is there an increased risk for in Pagets?
#1 most common bone infection?
How are bone infections spread?
What is a skeletal change associated with chronic renal disease and can cause bone resorption and softening
What can osteodystrophy put children at risk for?
What type of fracture has overlying tissue that is intact?
What type of fracture has ends of bone that are not aligned?
what type of fracture has open skin with bone sticking out?
What type of fracture has splintered bone?
What causes a pathological fracture?
What are two types of bone cysts?
who gets solitary bone cysts and where are they located and x-ray finding?
young men 10-20
distal long bone
x ray shows smooth, thin cortex
Who gets aneurismal bone cysts, where are they, and what does x-ray look like?
honey combed on xray
more likely to recur than solitary
benign bone tumor and histology
cherry red tissue
What syndrome has multiple osteoid osteomas?
primary bone malignancy?
What disease has an increased risk for osteosarcomas?
What is the third most common malignancy in children?
Where does osteosarcoma met to?
where do you most commonly see osteosarcoma?
distal femur, near knee
Skip lesions within bone
spicules of Ca in adjacent soft tissue
uncommon bone tumor found around the knee in distal femur or proximal tibia
- tumor produces collagen matrix
sheets of cells
x-ray findings giant cell tumor
cortical erosion and thinning which expands to bone contours without a border of new bone
hist of giant cell tumor
oval tumor cells and multinucleated giant tumor cells
malignant muscle tumor in children
malignant tumor of bone composed of rounded cells that are uniform in size
- mainly in children age 13-14
Ewing Sarcoma on x-ray
malignant disease of plasma cells in bone marrow
malignant plasma B cells
fracture and bone pain
what are 4 types of CA that met to bone?
In children, what types of CA met to bone?