Quiz 4 Bone Flashcards Preview

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Flashcards in Quiz 4 Bone Deck (50):
1

softening of bone

osteomalacia

2

dense or hardening bone

osteopetrosis

3

porus bone

osteoporosis

4

brittle bone disease

osteogenesis imperfecta

5

Osteogenesis imperfect is defective connective tissue due to what?

deficiency in normal type 1 collagen which forms bone matrix

6

idiopathic avascular osteonecrosis of epiphysis of femoral head leading to interruption of blood supply to head of femur

legg calve perthes syndrome or avascular necrosis

7

osteomalacia in children is called what and due to what deficiency?

Rickets
vit D

8

In children under 4 who have Rickets what do you see?
In chidlren over 4 what do you see?

under 4 = leg bowing = genu varum
over 4 = knock knees (genu valgum)

9

what does x-ray of rickets pt show?

rackitic rosary/beading of ribs of costochondral joints

10

secondary osteoporosis is caused by what?

CA, endocrine, drugs, malabsorption

11

Are osteoclasts or blasts more active in osteoporosis

Clasts because they are breaking down bone.

12

What is most common sequelae of osteoporosis and location?

fracture of vertebrae

13

overactivity of osteoclasts and osteoblasts with multiple bones being affected?

Paget's disease

14

hist of Paget's

mosaic pattern of lamellar bone (jigsaw)

15

x-ray of skull with Paget's

cotton ball

16

What is unique about Page'ts fracture?

straight line across

17

what labs are elevated in Pagets?

alk phos

18

what is there an increased risk for in Pagets?

osteosarcoma

19

#1 most common bone infection?

staph

20

How are bone infections spread?

hematogenous
soft tissue
direct trauma

21

What is a skeletal change associated with chronic renal disease and can cause bone resorption and softening

Renal osteodystrophy

22

What can osteodystrophy put children at risk for?

rickets

23

What type of fracture has overlying tissue that is intact?

simple/closed

24

What type of fracture has ends of bone that are not aligned?

displaced

25

what type of fracture has open skin with bone sticking out?

compound/open

26

What type of fracture has splintered bone?

comminuted

27

What causes a pathological fracture?

disease

28

What are two types of bone cysts?

solitary
aneurismal

29

who gets solitary bone cysts and where are they located and x-ray finding?

young men 10-20
distal long bone
x ray shows smooth, thin cortex

30

Who gets aneurismal bone cysts, where are they, and what does x-ray look like?

Women 20-30
long bone
honey combed on xray
more likely to recur than solitary

31

benign bone tumor and histology

osteoid osteoma
cherry red tissue

32

What syndrome has multiple osteoid osteomas?

Gardners

33

primary bone malignancy?

osteosarcoma

34

What disease has an increased risk for osteosarcomas?

Pagets

35

What is the third most common malignancy in children?

osteosarcoma

36

Where does osteosarcoma met to?

lung

37

where do you most commonly see osteosarcoma?

distal femur, near knee

38

Skip lesions within bone
spicules of Ca in adjacent soft tissue

osteosarcoma

39

uncommon bone tumor found around the knee in distal femur or proximal tibia
- tumor produces collagen matrix

fibrosarcoma

40

fibrosarcoma hist

sheets of cells

41

x-ray findings giant cell tumor

cortical erosion and thinning which expands to bone contours without a border of new bone

42

hist of giant cell tumor

oval tumor cells and multinucleated giant tumor cells

43

malignant muscle tumor in children

rhabdosarcoma

44

malignant tumor of bone composed of rounded cells that are uniform in size
- mainly in children age 13-14

Ewing Sarcoma

45

Ewing Sarcoma on x-ray

moth eaten

46

malignant disease of plasma cells in bone marrow

multiple myeloma

47

malignant plasma B cells
fracture and bone pain
lytic lesions

multiple myeloma

48

what are 4 types of CA that met to bone?

lung
kidney
breast
prostate

49

In children, what types of CA met to bone?

neuroblastoma
Wilm's tumor
osteosarcoma
Ewing Sarcoma

50

when do you see ivory vertebra sign?

metastatic ca
pagets disease