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Flashcards in Self study 5 Deck (70):
1

2 types of tumors in renal ca

wilms tumor
renal cell carcinoma

2

2 types of tumors in renal ca

wilms tumor
renal cell carcinoma

3

when does wilms tumor usually present

peds age 2-5yo

4

what is wilms tumor composed of

elements that are similar to normal fetal tissue: blastemic, stromal, epithelial tissue

5

what congential abns is wilms assoc with

anridia
hemihypertrophy
other abns of GI

6

anridia

abesnce or iris

7

hemihypertrophy

enlargement of one side of face or body

8

what gene has a mutation that causes wilms

wilms tumor gene on chr 11

9

characteristics of wilms tumor

solitary mass, sharply demarcated and encapsulated in kindey.
grows to large size

10

stage 1 wilsm tumor

limited to kidney
can be excised

11

stage 2 wilms tumor

extend to renal capsule and can be excised

12

stage 3 wilms tumor

extend to abdomen

13

stage 4 wilms tumor

mets to lung

14

presentation wilsm tumor

lage asymsymptomatic abd mass, pain, vomiting, heamturia, htn

15

tx for wilms tumor

sx, chemo, radiatio

16

what percent of renal cell carcinoma is clear cell carcinoma

60%

17

what % of RCC is chromophobic tumor

5-10%

18

what % of RCC is onocytomas

5-10%

19

what % of RCC are collectiing duct tumors

20

characteristics of clear cell carcinoma

clear cytoplasm, chr 3 deletion, arise from proximal tubular cells

21

et RCC

tumors affect poles, mostly upper pole
unclear

22

risk factors for RCC

smoking
kidney cancer
obseity (esp women)
occupational exposure to petroleum, heavy metals, asbestor,
acquired cystic kidney disease assoc with renal insuff

23

mnfts of early RCC

silent in early stages. symptoms mean advanced

24

mnfts late RCC

hematuria, flank pain, presence of palpable flank mass

25

dx RCC

urinalysis
renal mass
US/CT
MRI?

26

tx RCC

sx
chemo
immunotx

27

what sx is used in RCC

radical nephrectomy with node dissection

28

what immunotx is used in RCC

interferon alfa, IL2

29

what immunotx is used in RCC

interferon alfa, IL2

30

when does wilms tumor usually present

peds age 2-5yo

31

what is wilms tumor composed of

elements that are similar to normal fetal tissue: blastemic, stromal, epithelial tissue

32

what congential abns is wilms assoc with

anridia
hemihypertrophy
other abns of GI

33

anridia

abesnce or iris

34

hemihypertrophy

enlargement of one side of face or body

35

what gene has a mutation that causes wilms

wilms tumor gene on chr 11

36

characteristics of wilms tumor

solitary mass, sharply demarcated and encapsulated in kindey.
grows to large size

37

stage 1 wilsm tumor

limited to kidney
can be excised

38

stage 2 wilms tumor

extend to renal capsule and can be excised

39

stage 3 wilms tumor

extend to abdomen

40

stage 4 wilms tumor

mets to lung

41

presentation wilsm tumor

lage asymsymptomatic abd mass, pain, vomiting, heamturia, htn

42

tx for wilms tumor

sx, chemo, radiatio

43

what percent of renal cell carcinoma is clear cell carcinoma

60%

44

what % of RCC is chromophobic tumor

5-10%

45

what % of RCC is onocytomas

5-10%

46

what % of RCC are collectiing duct tumors

47

characteristics of clear cell carcinoma

clear cytoplasm, chr 3 deletion, arise from proximal tubular cells

48

et RCC

tumors affect poles, mostly upper pole
unclear

49

risk factors for RCC

smoking
kidney cancer
obseity (esp women)
occupational exposure to petroleum, heavy metals, asbestor,
acquired cystic kidney disease assoc with renal insuff

50

mnfts of early RCC

silent in early stages. symptoms mean advanced

51

mnfts late RCC

hematuria, flank pain, presence of palpable flank mass

52

dx RCC

urinalysis
renal mass
US/CT
MRI?

53

tx RCC

sx
chemo
immunotx

54

what sx is used in RCC

radical nephrectomy with node dissection

55

when can nephron sparing sx be used in RCC

if both kidneys are involved

56

what immunotx is used in RCC

interferon alfa, IL2

57

2 groups of bladder ca

low grade noninvase tumor
high grade invasive tummor

58

high grade invasive tumor

invade bladder wall, met

59

where does bladder ca arise from

transitional epth of bladder wall

60

prognosis of noninvasive bladder ca

may reoccur after resec, but good prognosis

61

et of bladder ca

idiopathic
carcinogenes excreted in urine?
parasites

62

what carcinognes that are excr in urine may cause bladder ca

aromatic amines used in dye industry
products used in rubber, textiles, paint, chemicals, petroleum

63

risks for bladder ca

smoking
renal calculi
chronic bladder infc

64

what parasite is thought to play a role in bladder ca

schistomsoma heamtobium

65

freq mnts of bladder ca

microscopic, and gross
painless hematuria
freq, urgency, dysuria

66

dx for bladder ca

cytologic stides
excretory urography
cystoscopy
biopsy

67

what is used for staging bladder ca

US, CT, MRI

68

what does tx for bladder ca

depends on stage and grade

69

tx for bladder ca

sx, radiatino, chemo

70

which sx are common in bladder ca

endoscopic resec
diathermy
segmental surgical resec
cystectomy