Unit 7 Part 2 Flashcards Preview

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Flashcards in Unit 7 Part 2 Deck (44):
1

asthma

reversible episodes of airway obstr dt inflm, subside w intervention

2

what causes m spasm in asthma

hyperactivity of aw m. wall

3

why do asthma pts experience inc reoccurence

inc sensitivity to stimuli

4

asthma et

complex trait

5

which pts have inc in asthma

pts with eczema or hay fever

6

common asthma triggers

allergens
aw irritants
exercise
strong odours
cold air

7

basic patho for asthma

trigger -> inc H rxn -> 2 phased response

8

what is it to be said about the 2 phases of asthma response

may not always progress to the 2nd part

9

what does an allergen cause stimulation of

mast cells

10

what do mast cells release when triggered by an allergen

histamine, luekotrenes, interluekins, prostaglandins

11

what does release of mediators by mast cells cause

bronchospasm, vasodilation

12

what is the first part of the late phase

infiltration of inflm cells, rls of cytokines and interluekins

13

in late phase, what does aw inflm do (5)

inc aw response, edema, dec mucociliary fx, epithelial injury, dec air flow

14

2 fx of luekotreines

dx type 1 H reaction
leads to aw inflm

15

what must occur for the acute phase to happen

prior sensitization to allergen

16

what happens in the acute phase during subsequent exposure to an allergen

allergen binds to IgE coated mast cells causing mediator rls and inflm

17

how do allergens enter submucosa in teh acute phase

via intercellular junctions that open dt inflm/med rls

18

what causes aw edema in the acute phase

inc permb and inc mucous sec

19

what fx stimulates bronchospasm (acute phase)

PNS

20

what leads to lumen compromise in the acute phase

exudate, mucous, aw swelling

21

what is dyspnea and wheezing dt

forceful airflow thru lumen

22

what compensatory change occurs in acute phase of asthma, why

aw constr dt ag stimulation to dec amount of air intake

23

peak and duration of acute phase

5-10m
1h

24

what effects inc in the late phase of asthma

inc in other inflm cells
self perpetuating cycle with inc length
inc in vasc perm, edema, aw responsiveness, edema

25

when does the late phase in asthma peak

4-8h

26

how long can the late phase in asthma last

days-wks

27

what does the influx of inflm cells in the late phase cause (2)

epith damage
dec mucociliary fx

28

what is dec mucociliary fx in the late phase related to

inc bact growth rt inc mucous prod

29

what happens during a hyperactive aw response dt inflm

responds to NEW triggers
more freq and sev episodes

30

what receptors cause bronchoconstr

alpha adrenegic receptors

31

what receptors cause bronchodil

beta adrenegic receptors

32

what secondary messenger facilitates physologic bronchoconst/dilation

CAMP

33

what theory is queryed when questioning lack of bronchodilation in asthma

lack of beta receptor stimulation

34

what mnfts occur during an attack

dyspnea,wheezing, immbolization, inc WOB, bronchospasm, coughing, ventilatory compromise

35

why is a pt with an asthma attack immbolized

dt inability to breathe

36

what does inc WOB present with

nasal flaring and accessory m use

37

why does a pt with an asthma attack cough

in attempt to clear sec from URT

38

Dx for asthma

Hx, px, labs, pulm fx tests

39

what is important to remember about pulm fx tests when dxing asthma

you cannot use them to seperate asthma and aCOPD

40

prevention and prophylaxis for asthma attacks

avoid ag's (pt spec)
no smoking, including 2nd hand smoke

41

what 4 step course of drugs is used to tx asthma

inhaled short acting bronchodilator
inhaled steroid
add long acting bronchodilator
short course oral steroid

42

what 3rd drug might be added to the 4step course when txing asthma

leukotrine receptor agonist or theophylline

43

which drugs from the 4 course tx are inc in long phase

inhaled steroids, long acting bronchodilators

44

which drugs from the 4 course tx are usually only used in the short phase

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