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Flashcards in Unit 17 Deck (69):
1

what percent of pts with ovarian ca have mets at dx

75 percent

2

what does the malignancy mimick in ovo ca

action of normal ovary

3

which cancer is the most lethal reprod ca

ovarian

4

et of ovarian ca

gene mutation

5

4 risks of ovarian ca

ageing
autosomal dominant inherited forms
family hx
other

6

aging as a risk fator

inc in ages 65-84 yo. inc ovulatory age -> inc risk dt exposure

7

what other reasons are risks for bc

nulliparity
infertility
dysmennorhea

8

what 3 areas does OC arise

epithelial (90)
germ cell
stromal tumour

9

what strs does OC affect via extension and invasion

tubes
uterus
ligaments,
other ovary v

10

what strs does OC affect bia seeding

bowel, mesentary, liver, peritoneum

11

late mnfts of OC

abdm distention related to inc size of tumor causing p on other strs

12

papillation

tiny tumors inside/on ovary with different shapes and sizes (primary ovary tumors)

13

early mnfts of OC

none

14

what non spec GI mnfts may occur in OC

flatulence, GI discomofrt, abdm distention

15

what GU mnfts mah occur in OC

pain, urinary or bowel bobstr

16

what mnfts of OC may affect the abdm cavity

ascites and dyspnea

17

what mnft may lead to US and exploratory sx

pelvic mass

18

tx for OC

aggressive tx. combo of sx and chemo

19

when is a lapratomy done in OC

6-24m

20

what is the most common reprod ca in women

uterine ca

21

when does UC peak

55-65 yo

22

Et for uc

hyperestroginsm
family hx
some cases may be E independent

23

risks for uc 7

obesity
age
excessive pelvic radiation
hx or family hx of a reprod ca
DM
htn
inc e with dec P

24

why is obesity a risk factor for uc

adipose tissue retains and produces E

25

what type of carcinoma is usually in UC

adenocarcinoma

26

patho of UC

normal hyperplasia -> inc E -> dysplasia ->ana plasia

27

2 types of UC

type 1 and type 2

28

what percent of UC is type 1 UC

90

29

Which type of UC is E dependent/sensitive

type 1

30

which type of UC has good prognosis

type 1

31

in which UC does endometrial hyperplasia ocur

type 1

32

what percent of cases are type 2 UC

10 percent

33

what is type 2 uc associated with

atrophy of endometrium

34

which type of UC has poorer prognosis

2

35

what type of progresion does UC have

slow

36

where does UC extend to

myometrium, vagina

37

how does UC met (late)

lymph and blood

38

mfnts of UC

endometrial bleeding inbetween periods and prolonged. mnfts rt spread

39

tx of UC

based on stage
sx c radiation

40

what percent of cervical ca is avoidable

100

41

what percent of cervical ca is curable in situ

100

42

how long is the preca stage of cervical ca

2 years

43

risks of CCA

HPV
smoking
hx of stds

44

how many strains of hpv are there? what percent of them are sexually transmitted

100
40

45

what strains of HPV are most concerning

6,11,16,18

46

what do hpv strains 6/11 cause

90% genital warts

47

what do hpv strains 16/18 cause

70% cervical ca

48

who has increased risk of sexual transmissin of hpv strains 6,11,16,18

early aged sex and numerous partners

49

origin of CCA

squamous cell

50

how does cca originate

as dysplasia (preca lesion)

51

what is it called when cca moves into the epith layer

carcinoma in situ

52

what is it called when cca moves into deeper layers

invasive ca

53

characteristics of invasive cca spread

spreads in and out in a cone shape

54

pap smear

slough off of exfoliating cells that are stained and look for dysplasia

55

what do positive pap smears have

a CIN and a number

56

what does CIN stand for

cervical intraepitheal neoplasia

57

CIN1

mikd dysplasia pre ca

58

cin2

mod dysplasia pre ca

59

cin 3

sev dysplasia and carcinoma in siut

60

how does cca met

via lymph

61

what do you do if your pap is positive

repeat test

62

dx for cca

pap
coloscopy

63

mfnts of cca

vaginal dc and bleeding bet menses
mettorrhagia
inc freq and lenghth of menses
late sign: pain

64

tx of cca (early)

excision

65

tx of cca (late)

excision and radiation
radical hysterectomh

66

types of excsion for cca

crytosx
conization
laser

67

crytosx

induce cell necrosis via freezing

68

conization sx

remove cone shaped piece

69

laser sx

necrosis via heat