Unit 17 Flashcards

1
Q

what percent of pts with ovarian ca have mets at dx

A

75 percent

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2
Q

what does the malignancy mimick in ovo ca

A

action of normal ovary

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3
Q

which cancer is the most lethal reprod ca

A

ovarian

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4
Q

et of ovarian ca

A

gene mutation

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5
Q

4 risks of ovarian ca

A

ageing
autosomal dominant inherited forms
family hx
other

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6
Q

aging as a risk fator

A

inc in ages 65-84 yo. inc ovulatory age -> inc risk dt exposure

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7
Q

what other reasons are risks for bc

A

nulliparity
infertility
dysmennorhea

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8
Q

what 3 areas does OC arise

A

epithelial (90)
germ cell
stromal tumour

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9
Q

what strs does OC affect via extension and invasion

A

tubes
uterus
ligaments,
other ovary v

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10
Q

what strs does OC affect bia seeding

A

bowel, mesentary, liver, peritoneum

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11
Q

late mnfts of OC

A

abdm distention related to inc size of tumor causing p on other strs

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12
Q

papillation

A

tiny tumors inside/on ovary with different shapes and sizes (primary ovary tumors)

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13
Q

early mnfts of OC

A

none

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14
Q

what non spec GI mnfts may occur in OC

A

flatulence, GI discomofrt, abdm distention

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15
Q

what GU mnfts mah occur in OC

A

pain, urinary or bowel bobstr

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16
Q

what mnfts of OC may affect the abdm cavity

A

ascites and dyspnea

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17
Q

what mnft may lead to US and exploratory sx

A

pelvic mass

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18
Q

tx for OC

A

aggressive tx. combo of sx and chemo

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19
Q

when is a lapratomy done in OC

A

6-24m

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20
Q

what is the most common reprod ca in women

A

uterine ca

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21
Q

when does UC peak

A

55-65 yo

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22
Q

Et for uc

A

hyperestroginsm
family hx
some cases may be E independent

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23
Q

risks for uc 7

A
obesity
age
excessive pelvic radiation
hx or family hx of a reprod ca
DM
htn
inc e with dec P
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24
Q

why is obesity a risk factor for uc

A

adipose tissue retains and produces E

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25
Q

what type of carcinoma is usually in UC

A

adenocarcinoma

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26
Q

patho of UC

A

normal hyperplasia -> inc E -> dysplasia ->ana plasia

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27
Q

2 types of UC

A

type 1 and type 2

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28
Q

what percent of UC is type 1 UC

A

90

29
Q

Which type of UC is E dependent/sensitive

A

type 1

30
Q

which type of UC has good prognosis

A

type 1

31
Q

in which UC does endometrial hyperplasia ocur

A

type 1

32
Q

what percent of cases are type 2 UC

A

10 percent

33
Q

what is type 2 uc associated with

A

atrophy of endometrium

34
Q

which type of UC has poorer prognosis

A

2

35
Q

what type of progresion does UC have

A

slow

36
Q

where does UC extend to

A

myometrium, vagina

37
Q

how does UC met (late)

A

lymph and blood

38
Q

mfnts of UC

A

endometrial bleeding inbetween periods and prolonged. mnfts rt spread

39
Q

tx of UC

A

based on stage

sx c radiation

40
Q

what percent of cervical ca is avoidable

A

100

41
Q

what percent of cervical ca is curable in situ

A

100

42
Q

how long is the preca stage of cervical ca

A

2 years

43
Q

risks of CCA

A

HPV
smoking
hx of stds

44
Q

how many strains of hpv are there? what percent of them are sexually transmitted

A

100

40

45
Q

what strains of HPV are most concerning

A

6,11,16,18

46
Q

what do hpv strains 6/11 cause

A

90% genital warts

47
Q

what do hpv strains 16/18 cause

A

70% cervical ca

48
Q

who has increased risk of sexual transmissin of hpv strains 6,11,16,18

A

early aged sex and numerous partners

49
Q

origin of CCA

A

squamous cell

50
Q

how does cca originate

A

as dysplasia (preca lesion)

51
Q

what is it called when cca moves into the epith layer

A

carcinoma in situ

52
Q

what is it called when cca moves into deeper layers

A

invasive ca

53
Q

characteristics of invasive cca spread

A

spreads in and out in a cone shape

54
Q

pap smear

A

slough off of exfoliating cells that are stained and look for dysplasia

55
Q

what do positive pap smears have

A

a CIN and a number

56
Q

what does CIN stand for

A

cervical intraepitheal neoplasia

57
Q

CIN1

A

mikd dysplasia pre ca

58
Q

cin2

A

mod dysplasia pre ca

59
Q

cin 3

A

sev dysplasia and carcinoma in siut

60
Q

how does cca met

A

via lymph

61
Q

what do you do if your pap is positive

A

repeat test

62
Q

dx for cca

A

pap

coloscopy

63
Q

mfnts of cca

A

vaginal dc and bleeding bet menses
mettorrhagia
inc freq and lenghth of menses
late sign: pain

64
Q

tx of cca (early)

A

excision

65
Q

tx of cca (late)

A

excision and radiation

radical hysterectomh

66
Q

types of excsion for cca

A

crytosx
conization
laser

67
Q

crytosx

A

induce cell necrosis via freezing

68
Q

conization sx

A

remove cone shaped piece

69
Q

laser sx

A

necrosis via heat