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Flashcards in Unit 20 Deck (62):
1

cellulitis

bact infc of deeper dermis and subcu

2

why is cellulitis danger

dt continuity of sub cu layer and inc in space

3

what causes cellulitis

bact that enters these layers, mostly
strep puogenes
staph aures

4

strep pyogenes

aerobic bact, oppurtunistic, inc in strep throat, exists in urt as normal flora in dec numbers

5


staph aures

appears in dec numbers as normal flora on skin. also normal flora in nasal pts in some pts

6

how does bact enter in cellulitis

compromised skin

7

where does cellulitis bact norally enter

foot (via athletes foot) and ascends up

8

what other areas does cellulitis affect

hands, pinna of ear, feet, calves

9

where else can bact spread in cellulitis

lympathetic system

10

tx for abx

mild: oral abx, sev: IV abx (7-14)d
inc reoccurance

11

comp if cellulitis if left untx

lymphangitis
bacteremia via sepsis
gangrene

12

psoriasis

chornic integ condition with extensive inflm

13

how long does it take for basal cells to move up to the surface normally

1 MO

14

how long does it take basal cells to move up to the surface in psorasis

3day

15

what does the rapid cell cycle in psoriasis cuase

abn formed cells, cell stacking -> forming scaly patches

16

et psorasis

largely idiopathic
genetic (30percent)
autoimmunity

17

what triggers autoimmune resp in psoraisis

t cells triggered by skin trauma

18

patho of psorasis

skin truama-> activated t cells -> mediators -> accelerated epidermal cycle and abn/unexplained change in growth of keratinocytes and blood vessels

19

what does the influx of infm cells cause in psorasis

skin/inflm damage

20

why do cells stack in psorasis

inc epidermal cell turnover meaning cells cant die and shed, so they stack

21

mnfts psorasis

prsoriatic patches
nail dystrophy and damage with progression
prostatic arthritis

22

where do prostatic patches occur in psorasis

elbows, knees,scalp, sacrum

23

why does nail pitting and dystrophy occur in psoriasis

change in keratin -> inc amounts -> brittle nails

24

what percent of pts experience brittle naisl

30-50 percent

25

psoriatic arthritis

autoimmune problem in smaller, distal joints like fingers and toes

26

what percent of pts have psoriatic arthritis

15-20% ots

27

1st approach tx in psoriasis

topical meds

28

which topical meds may be used in psorasis

vit d
steroids
renenoids

29

fx of vit d in topical meds for psorasis

dec of # keratinocytes and t cells, regulates them

30

fx of retenoids in topical med tx for psorasis

dec inflm and modulate keratinocytes

31

more sev approach for psorasis

methotrexate
cyclosporine
phototx
topical application of tar
biologic agents like tnf

32

cyclosporine

cytotoxic, immunosupressants

33

fx of phototx in psorasis

controlled and regulate exposure to UV B light to surpress and decrease cell cycle

34

fx of biologic agents like TNF

causes apoptosis of extra normal cells

35

what percent of skin ca's make up all ca

1/3

36

3 major types of skin ca

basal cell carcinoma
squamous cell carcinoma
malignant melanoma

37

what 2 types of ca;s make up 90% of skin cas

basal cell carcinoma
squamous cell carcinoma

38

et of skin ca

inc sun exposure/uv light exposure causing cumulative exposure

39

actinic keratosis

pre ca lesion most pts present with

40

what percent of cure rate occurs with early detection

95%

41

nevus/nevi

moles/beningn growth

42

basal cell carcinoma

most common ca with best progress

43

where does basal cell carcinoma arise

in basal cells of lower epidermis

44

characteristics of basal cell carcinoma

slow growing, appears on exposed surfaces,.
local invastion+destr, no pain

45

characteristics of lesions on basal cell carcinoma

dome shaped, nodular lesion, similar in most pts in early stages

46

does basal cell carcinoma met

no

47

tx/dx for basal cell carciona

biopsy

48

what happens in late stage basal cell carcinoma

change in lesions with latge stages (pt spec)

49

where does squamous cell carcinoma originate

keratinocytes

50

where does squamous cell carcinoma usually appear

exposed surfaces

51

characteristics of leisons ins squamous cell carcinoma

fast growing, poorly defined, with variable appearance

52

can squamous cell carcinoma affect local strs

yes (deep skin

53

where does squamous cell carcinoma met to

local lymph nodes

54

malignant melanoma origin

melanocytes

55

characteristics of malignant melanoma

worst form, inc progression, rapid progression with mets

56

where does malignant melanoma form

exposed and non exposed surfaces

57

main features of malignant melanoma

change in lesion over 3-8mo
double/inc in size
change in colour/multi colours

58

what other mnfts occur in lesions of malignant melanoma

prutis, bleeding, crusting, ulcerations, irregular border, raised border

59

where does malignant melanoma mets to

bone, brain, lung , liver

60

tx for skin ca

early detection
excision

61

what is skin ca prevalence proportional to

age (cumulative exposure)

62

what is skin ca inversely proportional to

melanin