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Flashcards in Unit 23 Deck (28):
1

why is secondary bone ca (BCA) common

because of inc vascularity of bone -> inc blood moves here -> inc probablity of emboli to move thru bone

2

where does most bone growth occur

metaphysis

3

what does bone form from

cartildige

4

why is identification of primary bca hard

diverse types

5

what do we identify bone ca based on

histology
location of ca in skeleton and in bone itself

6

what type of tumor is osteosarcoma

bone forming

7

how common is osteosarcoma

most common

8

where does osteosarcoma usually originate (skeleton)

around knee

9

characteristics of mets in osteosarcoma

quick and easy, to lung

10

what pts does 75% of osteosarcoma occur in

pts under 20

11

why does most osteosarcoma occur in young pts

dt inc cell prolif/dna replication that occurs prior to the halt of longitudinal bone growth at age 20. inc cell prolif-> inc risk of gene mutation

12

what pts does 25 % of osteosarcoma occur in

geri pts with underlying pathologic bone disease eg pagets

13

why does 25% of osteosarcoma occur in geri puts

pts with bone diseaes have inc resoprtion and formation of bone, this means there is still cell prolif/dna replication -> risk for gene mutatin

14

other primary malignancies

chondrosarcoma
fibrosarcoma
others (ewings, osteoclastoma)

15

what percent of all ca mets to bone

50%

16

what percent of lung, breast and prostate ca's met to bone

>85

17

what type of lesions are in 2 bca

lytic or blastic

18

lytic lesion

space occupying lesion req destr of normal tissue

19

blastic lesion

lesion uses space to build up

20

what mnfts are common with secondary bone ca

pain rt inflm, swelling, fractures

21

what is a major comp of secondary bone ca

fractures

22

why do fractures occur in secondary bone ca

lytic lesions -> dec stress -> fracture

23

what medical imaging is used to dx bone ca

xr (only with substantial mets, necrosis, breakdown)
ct mri

24

what dx is used for bone ca

med imaging
biopsy
bone scan

25

fx of biopsy in bone ca

confirms malignancy and tells you the type (primary bca)

26

fx of bone scan in bone ca

may not be req, usually in secondary to confirm mets

27

tx for bca

chemo,radiation,sx
pain tx
prevent fractures

28

what type of sx is used in bca

block excision of bone then restorative grafting