Flashcards in Unit 23 Deck (28):
1
why is secondary bone ca (BCA) common
because of inc vascularity of bone -> inc blood moves here -> inc probablity of emboli to move thru bone
2
where does most bone growth occur
metaphysis
3
what does bone form from
cartildige
4
why is identification of primary bca hard
diverse types
5
what do we identify bone ca based on
histology
location of ca in skeleton and in bone itself
6
what type of tumor is osteosarcoma
bone forming
7
how common is osteosarcoma
most common
8
where does osteosarcoma usually originate (skeleton)
around knee
9
characteristics of mets in osteosarcoma
quick and easy, to lung
10
what pts does 75% of osteosarcoma occur in
pts under 20
11
why does most osteosarcoma occur in young pts
dt inc cell prolif/dna replication that occurs prior to the halt of longitudinal bone growth at age 20. inc cell prolif-> inc risk of gene mutation
12
what pts does 25 % of osteosarcoma occur in
geri pts with underlying pathologic bone disease eg pagets
13
why does 25% of osteosarcoma occur in geri puts
pts with bone diseaes have inc resoprtion and formation of bone, this means there is still cell prolif/dna replication -> risk for gene mutatin
14
other primary malignancies
chondrosarcoma
fibrosarcoma
others (ewings, osteoclastoma)
15
what percent of all ca mets to bone
50%
16
what percent of lung, breast and prostate ca's met to bone
>85
17
what type of lesions are in 2 bca
lytic or blastic
18
lytic lesion
space occupying lesion req destr of normal tissue
19
blastic lesion
lesion uses space to build up
20
what mnfts are common with secondary bone ca
pain rt inflm, swelling, fractures
21
what is a major comp of secondary bone ca
fractures
22
why do fractures occur in secondary bone ca
lytic lesions -> dec stress -> fracture
23
what medical imaging is used to dx bone ca
xr (only with substantial mets, necrosis, breakdown)
ct mri
24
what dx is used for bone ca
med imaging
biopsy
bone scan
25
fx of biopsy in bone ca
confirms malignancy and tells you the type (primary bca)
26
fx of bone scan in bone ca
may not be req, usually in secondary to confirm mets
27
tx for bca
chemo,radiation,sx
pain tx
prevent fractures
28