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Flashcards in Self Study 7 Deck (30):
1

systemic lupus erythemaosus (SLE)

chronic inflm disease, major ruematic disease, can affect any organ system

2

which sex has inc predominance in SLE (with ratios)

10-1, 30-1 in child bearing years

3

which races have inc in sle

african, hispanic, asian, aboriginal

4

et sle

idiopathic
genetic predispostion
imbal in sex hormones
UV light, food, infections agents
drugs

5

which genes show a genetic link in SLE

hla-dr and hla-dq loci in MHC class II

6

which group of people has inc in genetic presdisopstion to sle

identical twins

7

which sex hormone imbal may cause sle

E

8

what drugs may cause sle

hydralazine
procainmaide

9

what is there inc prod of in SLE

Ab's against self and non self ags

10

what type of cells are hyper active in SLE

B cells

11

what happens with an inc in Abs and B cell hyperactivity

direct damage to tissues or combine with other ags to form tissue damaging IC

12

what autoantibodies occur in SLE

antinucleur antibodies (ANA), antiDNA

13

what do androgens protect agains in Sle

estrogen favour development

14

what happens when esterogen favour dev occurs

imbalance

15

inc response in waht causes autoabs form

H imbal causes inc response from helper T cells

16

dec response of what causes autoabs to form

H imbal causes dec suppressor t cell

17

MS mnfts of sle

arthralgias and arthritis. eventual l/o fx of han
rupture of intrapatellar and achilles tendons

18

skin mnfts of sle

butterfly rash on nose and cheeks, fingertip lesions, nailfold infarct, splinter hemmorhage, hair loss, mucous memb lesions, sun sensitivty

19

what type of fingertip lesions form in sle

periungal erythema

20

renal mfnts of sle

glomerulonephritis, interstital nephritis, nephrotic sydrome

21

what may neprotic syndrome lead to

edema in legs, abd, face, RF

22

pulm mnfts of sle

pleural effusion, pleuritis, acute pneumonitis, pulm hemmr, chronic interstital lung disease
pulm embolism

23

CV mnfts of sle

pericarditis with pleural effusion, cardiac tamponade, congenital heart block in infants (mom has SLE), secondary HD, htn, ischemic HD, valvular lesions with ineffective endocarditis

24

CNS mfnts of sle

stroke, hemmorhage, IR that releases antineuronal Abs
seizures
depression and euphoria, dec cognition, altered LOC

25

why may stroke or hemmor occur as a cns mnft of sle

acute vasculitis

26

what do antinueronal abs attack

nerves, damage blood vessels

27

hematologic mfnts of sle

hemolytic anemia, leukopneia, lymphopenia, thrombocytopenia, plaque like lesions on head, scalp, neck

28

dx for sle

immunofloresence test for ANA. positive ana result may indicate disease.
antiDNA ab pressence

29

tx for sle

manage acute and chronic symtoms
prevent l/o organ fx, dec disability, prevent comps

30

what meds may be used to tx sle 5

nsaids
antimalarial drugs
corticosteroids
immunosuppresives
cyclosphamide