Unit 13 Flashcards Preview

PAtho > Unit 13 > Flashcards

Flashcards in Unit 13 Deck (67)
Loading flashcards...
1

at what age does bph begin to dev

>55

2

main risk factor for bph

aging

3

characteristic of prostatic growth with age

slow, gradual growth

4

how is growth of prostate characterized in bph

periurethral growth, originating in center of gland

5

what type of growth is bph and what cells areinvolved

hyperplasia and hypertrophy
m. and exocrine epith tissue

6

number one risk of bph

aging

7

what change does age cause in bph

change in androgen levels

8

et of bph

aging
genetic predisposition
race (inc in blacks, dec in asian)
diet (directly linked to genes and race)

9

what are the 2 male androgens

T
DHT

10

what percent of t is converted to dht

95

11

how is t converted to dht

via ez 5 alpha reductase

12

what is dht responsible for

str, fx, growth of prostate

13

what is the physiologic fx of E in men

facilitates action of DHT on cells by sensitizing them -> inc effect of DHT

14

what happens to the T:E ratio as men age

qualatative dec in T while E remains the same

15

what happens to E when T decreases

it makes E relatively more significant

16

what does the inc significance of E do to prostatic cells

makes them more sensitive, so DHT has more effect

17

why does urethral compression occur in BPH

inc in tissue size is space occupying -> urethral compression

18

when does urine accum occur

with inc urethral compression

19

what happens when urine accums

inc urge to urinate, inability to enter bladder,, residual badder volume

20

what 2 compensatory changes occur to prevent ballder rupture

1. bladder wall thickens
2. diverticula/trabeculae in bladder expand to inc bladder size

21

why is thickening of the bladder wall worsening the problem

we can now retain urine longeer

22

why is increassing bladder size worsening the problem

promotes urine stasis

23

2 complications of urine stasis

UTI/infc
renal calculi

24

why may renal calculi occur with urine stasis

rt percipitable components in urine

25

what happens when the bladder is full of urine

backs up into urine and kidney

26

hydrouretur

distention of uretur to accomodate inc urine vol

27

fish hook uretur

occurs at point where uretur attatches to bladder. inc P on this points pulls uretur downwards making hook apperance

28

2 consequences of hydroeuretur

urine begins to accum in kidney
hydronephrosis

29

what happens when urine accums in kidney

inc p pushing out on glomerulus, inc P in capsule > P of filtrate entering capsule -> no filtration

30

what leads to hydronephrosis

no filtration rt to no P gradient to faciliate filtration