Unit 1: Neurotransmitters and Receptors Flashcards Preview

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Flashcards in Unit 1: Neurotransmitters and Receptors Deck (76):
1

L1: _____ ACh receptors have ionotropic actions.

Nicotinic

2

L1: _____ ACh receptors have metabotropic actions.

Muscarinic

3

L1: Acetylcholine is produced from a reaction between _____ and ______.

Acetyl-CoA and choline

4

L1: ACh is taken up into vesicles by ______.

Vesical Associated Transporter (VAT)

5

L1: ACh receptors can be divided into the _____ and ______ categories.

Muscarinic, Nicotinic

6

L1: ACh signals are terminated by _____.

Enzymatic degradation by ACh esterase

7

L1: Epinephrine-binding receptors include ______.

alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors

8

L1: GABA receptors include ______.

GABA-A and GABA-B

9

L1: GABA signals are terminated by ______.

reuptake

10

L1: Glutamate is converted to _____ by astrocytes.

Glutamine

11

L1: Glutamate signals are terminated by _____.

reuptake

12

L1: Monoamine signals are terminated by ______.

reuptake

13

L1: Monoamines are taken up into vescles by ______.

Vesicular Monoamine Transporter (VMAT)

14

L1: Monoamines may be degraded in nerve terminals by ______.

Monoamine Oxidase (MAO)

15

L1: Norepinephrine-binding receptors include ______.

alpha-1, alpha-2, and Beta-1 adrenergic receptors

16

L1: The most important indoleamine transmitter is ______.

5-HT (Serotonin)

17

L1: The three most important catecholamines are ______. (3)

Dopamine, EPI, NOR

18

L1: Which G protein pathway decreases intracellular concentrations of cAMP?

G-i/o

19

L1: Which G protein pathway depresses adnylyl cyclase (AC)?

G-i/o

20

L1: Which G protein pathway increases intracellular concentrations of cAMP?

G-s

21

L1: Which G protein pathway increases intracellular concentrations of DAG and IP3?

G-q

22

L1: Which G protein pathway stimulates adenylyl cyclase (AC)?

G-s

23

L1: Which G protein pathway stimulates phospholipase C (PLC)?

G-q

24

L1: Which neurotransmitters participate in diffuse systems?

ACh and Monoamines

25

L1: Which neurotransmitters participate in hierarchical systems?

Glutamate and GABA

26

L2: ACh production is catalyzed by ______

Choline Acetyl Transferase (CAT)

27

L2: ACh receptors include ______.

N-N, M1-M4

28

L2: AMPA receptors increase ____ ion influx

Calcium and Sodium

29

L2: GABA is produced from ______

Glutamate

30

L2: GABA synthesis is catalyzed by ________.

Glutamic Acid Decarboxylase

31

L2: GABA-__ receptors are ionotropic and open ____ channels.

A; Chloride

32

L2: GABA-__ receptors are metabotropic and stimulate G-__

B; i/o

33

L2: Glutamate receptors include ______.

NMDA, AMPA, Kainate, R1-R8

34

L2: Glutamine conversion to glutamate is catalyzed by _______.

Glutaminase

35

L2: In the rate-limiting step of catecholamine synthesis ______ is converted to ______.

Tyrosine; L-Dopa

36

L2: Kainate receptors increase _____ ion influx

Sodium

37

L2: Monoamine receptors are grouped into three categories: _______.

Adrenergic, dopaminergic, serotonin

38

L2: NMDA receptors increase ____ ion influx

Calcium

39

L2: Serotonin receptors include _______.

5HT-1A, 5HT-1B, 5HT-1D, 5HT-2A, 5HT-2B, 5HT-2C, 5HT-3, 5HT-4

40

L2: The rate-limiting step in catecholamine synthesis is catalyzed by _______.

Tyrosine Hydroxylase

41

L2: The rate-limiting step in indoleamine synthesis is catalyzed by _______.

Tryptophan Hydroxylase (TpH)

42

L2: Which serotonin receptors are ionotropic? This receptor allows influx of _____.

5HT-3; cations

43

L3: 5HT-1A, 5HT-1B, and 5HT-1D receptors activate the G-__ pathway.

i/o

44

L3: 5HT-2A, 5HT-2B, and 5HT-2C receptors activate the G-__ pathway.

q

45

L3: 5HT-4 receptors activate the G-__ pathway.

s

46

L3: Alpha-1 adrenergic receptors activate the G-__ pathway.

q

47

L3: Alpha-2 adrenergic receptors activate the G-__ pathway.

i/o

48

L3: Beta-1 adrenergic receptors activate the G-__ pathway.

s

49

L3: Beta-2 adrenergic receptors activate the G-__ pathway.

s

50

L3: D1 receptors activate the G-__ pathway.

s

51

L3: D2 receptors activate the G-__ pathway.

i/o

52

L3: M1 and M3 ACh receptors activate the G-__ pathway.

q

53

L3: M2 and M4 ACh recptors activate the G-__ pathway.

i/o

54

L3: Name seven important neurotransmitters.

GABA, Glu, ACh, EPI, NOR, Dopamine, Serotonin

55

L3: R1 and R5 receptors activate the G-__ pathway

q

56

L3: R2 and R3 receptors activate the G-__ pathway and activate __ channels

i/o; Potassium

57

L3: R4, R6, R7, and R8 receptors activate the G-__ pathway

i/o

58

L3: Which ACh receptors activate the G-i/o pathway?

M2 and M4

59

L3: Which ACh receptors activate the G-q pathway?

M1 and M3

60

L3: Which adrenergic receptors activate the G-i/o pathway?

Alpha-2

61

L3: Which adrenergic receptors activate the G-q pathway?

Alpha-1

62

L3: Which adrenergic receptors activate the G-s pathway?

Beta-1 and Beta-2

63

L3: Which dopamine receptors activate the G-i/o pathway?

D2

64

L3: Which dopamine receptors activate the G-q pathway?

None

65

L3: Which dopamine receptors activate the G-s pathway?

D1

66

L3: Which Glutamate receptors activate the G-i/o pathway and activate potassium channels?

R2 and R3

67

L3: Which Glutamate receptors activate the G-i/o pathway only?

R4, R6, R7, and R8

68

L3: Which Glutamate receptors activate the G-q pathway?

R1 and R5

69

L3: Which Glutamate receptors activate the G-s pathway?

None

70

L3: Which serotonin receptors activate the G-i/o pathway?

5HT-1A, 5HT-1B, and 5HT-1D

71

L3: Which serotonin receptors activate the G-q pathway?

5HT-2A, 5HT-2B, and 5HT-2C

72

L3: Which serotonin receptors activate the G-s pathway?

5HT-4

73

L4: Name all ionotropic receptors. (6)

GABA-A, NMDA, AMPA, Kainate, N-N, 5HT-3

74

L4: Name all receptors that activate G-i/o. (14)

GABA-B, R2-R4, R6-R8, M2, M4, alpha-2, D2, 5HT-1A, 5HT-1B, 5HT-1D

75

L4: Name all receptors that activate G-q. (8)

R1, R5, M1, M3, alpha-1, 5HT-2A, 5HT-2B, 5HT-2C

76

L4: Name all receptors that activate G-s. (4)

Beta-1, Beta-2, D1, 5HT-4