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Unit 1: Neurotransmitters and Receptors Flashcards

1
Q

L1: _____ ACh receptors have ionotropic actions.

A

Nicotinic

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2
Q

L1: _____ ACh receptors have metabotropic actions.

A

Muscarinic

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3
Q

L1: Acetylcholine is produced from a reaction between _____ and ______.

A

Acetyl-CoA and choline

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4
Q

L1: ACh is taken up into vesicles by ______.

A

Vesical Associated Transporter (VAT)

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5
Q

L1: ACh receptors can be divided into the _____ and ______ categories.

A

Muscarinic, Nicotinic

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6
Q

L1: ACh signals are terminated by _____.

A

Enzymatic degradation by ACh esterase

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7
Q

L1: Epinephrine-binding receptors include ______.

A

alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors

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8
Q

L1: GABA receptors include ______.

A

GABA-A and GABA-B

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9
Q

L1: GABA signals are terminated by ______.

A

reuptake

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10
Q

L1: Glutamate is converted to _____ by astrocytes.

A

Glutamine

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11
Q

L1: Glutamate signals are terminated by _____.

A

reuptake

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12
Q

L1: Monoamine signals are terminated by ______.

A

reuptake

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13
Q

L1: Monoamines are taken up into vescles by ______.

A

Vesicular Monoamine Transporter (VMAT)

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14
Q

L1: Monoamines may be degraded in nerve terminals by ______.

A

Monoamine Oxidase (MAO)

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15
Q

L1: Norepinephrine-binding receptors include ______.

A

alpha-1, alpha-2, and Beta-1 adrenergic receptors

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16
Q

L1: The most important indoleamine transmitter is ______.

A

5-HT (Serotonin)

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17
Q

L1: The three most important catecholamines are ______. (3)

A

Dopamine, EPI, NOR

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18
Q

L1: Which G protein pathway decreases intracellular concentrations of cAMP?

A

G-i/o

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19
Q

L1: Which G protein pathway depresses adnylyl cyclase (AC)?

A

G-i/o

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20
Q

L1: Which G protein pathway increases intracellular concentrations of cAMP?

A

G-s

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21
Q

L1: Which G protein pathway increases intracellular concentrations of DAG and IP3?

A

G-q

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22
Q

L1: Which G protein pathway stimulates adenylyl cyclase (AC)?

A

G-s

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23
Q

L1: Which G protein pathway stimulates phospholipase C (PLC)?

A

G-q

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24
Q

L1: Which neurotransmitters participate in diffuse systems?

A

ACh and Monoamines

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25
L1: Which neurotransmitters participate in hierarchical systems?
Glutamate and GABA
26
L2: ACh production is catalyzed by ______
Choline Acetyl Transferase (CAT)
27
L2: ACh receptors include ______.
N-N, M1-M4
28
L2: AMPA receptors increase ____ ion influx
Calcium and Sodium
29
L2: GABA is produced from ______
Glutamate
30
L2: GABA synthesis is catalyzed by ________.
Glutamic Acid Decarboxylase
31
L2: GABA-__ receptors are ionotropic and open ____ channels.
A; Chloride
32
L2: GABA-__ receptors are metabotropic and stimulate G-__
B; i/o
33
L2: Glutamate receptors include ______.
NMDA, AMPA, Kainate, R1-R8
34
L2: Glutamine conversion to glutamate is catalyzed by _______.
Glutaminase
35
L2: In the rate-limiting step of catecholamine synthesis ______ is converted to ______.
Tyrosine; L-Dopa
36
L2: Kainate receptors increase _____ ion influx
Sodium
37
L2: Monoamine receptors are grouped into three categories: _______.
Adrenergic, dopaminergic, serotonin
38
L2: NMDA receptors increase ____ ion influx
Calcium
39
L2: Serotonin receptors include _______.
5HT-1A, 5HT-1B, 5HT-1D, 5HT-2A, 5HT-2B, 5HT-2C, 5HT-3, 5HT-4
40
L2: The rate-limiting step in catecholamine synthesis is catalyzed by _______.
Tyrosine Hydroxylase
41
L2: The rate-limiting step in indoleamine synthesis is catalyzed by _______.
Tryptophan Hydroxylase (TpH)
42
L2: Which serotonin receptors are ionotropic? This receptor allows influx of _____.
5HT-3; cations
43
L3: 5HT-1A, 5HT-1B, and 5HT-1D receptors activate the G-__ pathway.
i/o
44
L3: 5HT-2A, 5HT-2B, and 5HT-2C receptors activate the G-__ pathway.
q
45
L3: 5HT-4 receptors activate the G-__ pathway.
s
46
L3: Alpha-1 adrenergic receptors activate the G-__ pathway.
q
47
L3: Alpha-2 adrenergic receptors activate the G-__ pathway.
i/o
48
L3: Beta-1 adrenergic receptors activate the G-__ pathway.
s
49
L3: Beta-2 adrenergic receptors activate the G-__ pathway.
s
50
L3: D1 receptors activate the G-__ pathway.
s
51
L3: D2 receptors activate the G-__ pathway.
i/o
52
L3: M1 and M3 ACh receptors activate the G-__ pathway.
q
53
L3: M2 and M4 ACh recptors activate the G-__ pathway.
i/o
54
L3: Name seven important neurotransmitters.
GABA, Glu, ACh, EPI, NOR, Dopamine, Serotonin
55
L3: R1 and R5 receptors activate the G-__ pathway
q
56
L3: R2 and R3 receptors activate the G-__ pathway and activate __ channels
i/o; Potassium
57
L3: R4, R6, R7, and R8 receptors activate the G-__ pathway
i/o
58
L3: Which ACh receptors activate the G-i/o pathway?
M2 and M4
59
L3: Which ACh receptors activate the G-q pathway?
M1 and M3
60
L3: Which adrenergic receptors activate the G-i/o pathway?
Alpha-2
61
L3: Which adrenergic receptors activate the G-q pathway?
Alpha-1
62
L3: Which adrenergic receptors activate the G-s pathway?
Beta-1 and Beta-2
63
L3: Which dopamine receptors activate the G-i/o pathway?
D2
64
L3: Which dopamine receptors activate the G-q pathway?
None
65
L3: Which dopamine receptors activate the G-s pathway?
D1
66
L3: Which Glutamate receptors activate the G-i/o pathway and activate potassium channels?
R2 and R3
67
L3: Which Glutamate receptors activate the G-i/o pathway only?
R4, R6, R7, and R8
68
L3: Which Glutamate receptors activate the G-q pathway?
R1 and R5
69
L3: Which Glutamate receptors activate the G-s pathway?
None
70
L3: Which serotonin receptors activate the G-i/o pathway?
5HT-1A, 5HT-1B, and 5HT-1D
71
L3: Which serotonin receptors activate the G-q pathway?
5HT-2A, 5HT-2B, and 5HT-2C
72
L3: Which serotonin receptors activate the G-s pathway?
5HT-4
73
L4: Name all ionotropic receptors. (6)
GABA-A, NMDA, AMPA, Kainate, N-N, 5HT-3
74
L4: Name all receptors that activate G-i/o. (14)
GABA-B, R2-R4, R6-R8, M2, M4, alpha-2, D2, 5HT-1A, 5HT-1B, 5HT-1D
75
L4: Name all receptors that activate G-q. (8)
R1, R5, M1, M3, alpha-1, 5HT-2A, 5HT-2B, 5HT-2C
76
L4: Name all receptors that activate G-s. (4)
Beta-1, Beta-2, D1, 5HT-4

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