Unit 4: Limbic System and Memory Flashcards Preview

Neuro > Unit 4: Limbic System and Memory > Flashcards

Flashcards in Unit 4: Limbic System and Memory Deck (50):
1

L1: ________: ability to recall events or facts with specific temporal and spatial context

Declarative memory

2

L1: Activated calmodulin activates __________.

Ca/calmodulin-dependent kinsase II (CAMKII)

3

L1: CAMKII mediates increased incorporation of ______ into the postsynaptic cell membrane

AMPA receptors

4

L1: Hippocampal lesions impair ______ memory.

declarative

5

L1: Most declarative memories are stored in the ______, but function of the ______ is critical to storing these memories.

neocortex; hippocampus

6

L1: Stimulation of the _____ is highly reinforcing.

Nucleus accumbens

7

L1: When the NMDA receptor is activated, influx of calcium activates __________.

Ca-dependent calmodulin

8

L2: ______ projects to the BLA, CEA, and intercalated cell masses to inhibit ____ responses to afferent stimulation.

Medial prefrontal cortex; CEA

9

L2: _______ damage impairs the registering of emotional impacts of rewards and punishments caused by specific behaviors

Amygdala

10

L2: _______ memory is impaired when long term potentiation is disrupted due to a lesion in the ____ region of the hippocampus.

Associative; CA3

11

L2: _______ neurons undergo longterm potentiation, the basis for memory consolidation.

CA1 and CA3

12

L2: _________ neurons arise from the CA3 neurons and synapse on the ____ neurons.

Schaeffer Collateral; CA1

13

L2: _______: an indistinct ridge of tissue extending from the amygdala along the anterior perforated substance, curving into the interhemispheric fissure posterior to the medial olfacotr stria

Diagonal Band of Broca

14

L2: Amygdalar cells involved in appetitive conditioning project to the ________.

Nucleus accumbens

15

L2: Basolateral amygdalae neurons project to circuits for reward by providing input to the _______.

Nucleus accumbens

16

L2: CAMKII phosphorylates _______.

AMPA receptors and itself

17

L2: Cholinergic neurons in the basal forebrain release ACh in the ________.

insular cortex

18

L2: Coding of short-term memory occurs in the _______.

sensory cortex

19

L2: Coding of working memory occurs in the _______.

frontal lobes

20

L2: Exposure to a food results in stimulation of cholinergic neurons in the _______.

basal forebrain

21

L2: Fear extinction is mediated by neurons originating in the _______.

Medial prefrontal cortex

22

L2: Hippocampal output comes from cells in the ________, leaving via the _____.

CA1 and CA3 regions (Ammon's Horn); fornix

23

L2: In Broca's limbic lobe, the _____ feeds into the hippocampus.

Parahippocampal gyrus

24

L2: In Broca's limbic lobe, the outputs for the hippocampus are _________.

Parahippocampal gyrus, fornix

25

L2: In the Iowa Gambling Task, paitents with______ do not show a stress response with bad decks.

Ventromedial prefrontal cortex (VMPFC)

26

L2: In the Iowa Gambling Task, patients with _____ lesions showed no sin conductance in response to the receipt of rewards and punishment.

amygdala

27

L2: In the Iowa Gambling Task, patients with ______ lesions tend to draw from decks that give poor outcomes, even though they know they are losing

Ventromedial prefrontal cortex (VMPFC)

28

L2: In the Olds Self-Stimulation Experiments, the _____ was found to be a particularly strong reinforcing area.

Medial forebrain bundle

29

L2: Input to the hippocampus arrives from the ______ via the _______.

entorhinal cortex; perforant path

30

L2: Lesions in the striatum, cerebellum, or frontal cortex impair _____ memory.

procedural

31

L2: Memories of emotional experiences are encoded in the strengths of synaptic connections in the ________.

Lateral nuclei of the amydalae (basolateral amygdalae)

32

L2: Mossy fibers from the ______ also synapse on the _____ region of Ammon's Horn

Dentate gyrus; CA3

33

L2: Papez overestimated the role of ______ in emotional processes.

Hippocampus

34

L2: Papez's Circuit: Cingulate gyrus > _______

Hippocampus

35

L2: Papez's Circuit: Fornix > ________

Hypothalamus

36

L2: Papez's Circuit: Hippocampus > _______

Fornix

37

L2: Papez's Circuit: Hypothalamus > ________ > Cortex

Anterior thalamic nuclei

38

L2: Papez's Circuit: the _______ provides feedback to the cingulate gyrus.

Hypothalamus

39

L2: Perforant path axons synapse on the ________.

Dentate gyrus, CA3 region (Ammon's Horn)

40

L2: Stimulation of insular cortex neurons by basal forebrain cholinergic neurons causes _________.

Phosphorylation of the NMDA receptor

41

L2: The ______ in the amygdala mediates the release of CRH.

Bed Nucleus of the Stria Terminalis

42

L2: The ______ receives afferent stimulation from the viscera and projects this information to insular cortex neurons to pair aversive effects to taste sensations

amygdala

43

L2: The _______ is the main output structure of the amydala, providing _____-ergic output.

Central Nucleus of the Amygdala; GABA

44

L2: The _______ seems to be important for the prediction of consequences.

Ventromedial prefrontal cortex (VMPFC)

45

L2: The ________ is the ventral striatum and pallidum, located posterior to the olfactory stria

Anterior perforated substance

46

L2: The central nucleus of the amygdala projects to the ___________.

Midbrain reticular formation, hypothalamus

47

L2: The lateral nucleus of the amygdala receives input from the ________.

Auditory and somatosensory cortices

48

L2: The lateral nucleus of the amygdala transmits information to the _________.

Central nucleus of the amygdala

49

L2: VTA neurons can be divided into populations that project to the ______ (_____ pathway) and _______ (______ pathway).

nucleus accumbens/mesolimbic, prefrontal cortex/mesocortical

50

L3: Basolateral amydalae neurons can elicit fear via _______-ergic synapses providing input to the ______ and _______.

glutamatergic; basolateral amygdalae, bed nuclei of the stria terminalis