Unit 4: Pharmacology of Addiction Flashcards
(15 cards)
L1: _________: critical for executive function in providing control over impulses from destructive behavior.
Prefrontal Cortex
L1: Abuse risk is ______ with an increase in the rapidity of onset.
increased
L1: Drugs with the shortest half-lives have ______ abuse potential
higher
L1: Which route of administration is most likely to produce an intense rush or flash or euphoria?
IV
L1: Which route of administration is most useful in addiction treatment programs?
Oral
L1: Which route of administration possesses the most precise titration?
Inhalation
L1: Withdrawal effects are generally more severe for drugs with _____ half-lives.
short
L2: ______ reward system: connections from the prefrontal cortex to the nucleus accumbens to mediate impulse regulation
Reflective
L2: _______ reward system: functions to signal immediate prospect of pleasure or pain; provides motivational and behavioral drive to achieve that pleasure/avoid that pain
Reactive
L2: _______: integrative structure projecting to the VTA/nucleus accumbens, involved in formation of stimulus-reward associations.
Amygdala
L2: ______: memory circuit involved in mediating associations between biologic stimuli and environmental cues
Hippocampus
L2: Drugs with significant dependence liability enhance ______ activity in the _______.
dopamine; nucleus accumbens
L2: Stimulation of VTA neurons by natural reinforcers results in _____ release in the ______.
dopamine; nucleus accumbens
L2: The final common pathway for reinforcement and reward is the _______ pathway from the _______ to the ________.
mesolimbic; ventral tegmental area; nucleus accumbens
L2: What is the order of rapidity of onset from slowest to fastest? ______
Oral; Mucosal; IV; Inhalation
