Unit 4: Pharmacology of Addiction Flashcards Preview

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Flashcards in Unit 4: Pharmacology of Addiction Deck (15):
1

L1: _________: critical for executive function in providing control over impulses from destructive behavior.

Prefrontal Cortex

2

L1: Abuse risk is ______ with an increase in the rapidity of onset.

increased

3

L1: Drugs with the shortest half-lives have ______ abuse potential

higher

4

L1: Which route of administration is most likely to produce an intense rush or flash or euphoria?

IV

5

L1: Which route of administration is most useful in addiction treatment programs?

Oral

6

L1: Which route of administration possesses the most precise titration?

Inhalation

7

L1: Withdrawal effects are generally more severe for drugs with _____ half-lives.

short

8

L2: ______ reward system: connections from the prefrontal cortex to the nucleus accumbens to mediate impulse regulation

Reflective

9

L2: _______ reward system: functions to signal immediate prospect of pleasure or pain; provides motivational and behavioral drive to achieve that pleasure/avoid that pain

Reactive

10

L2: _______: integrative structure projecting to the VTA/nucleus accumbens, involved in formation of stimulus-reward associations.

Amygdala

11

L2: ______: memory circuit involved in mediating associations between biologic stimuli and environmental cues

Hippocampus

12

L2: Drugs with significant dependence liability enhance ______ activity in the _______.

dopamine; nucleus accumbens

13

L2: Stimulation of VTA neurons by natural reinforcers results in _____ release in the ______.

dopamine; nucleus accumbens

14

L2: The final common pathway for reinforcement and reward is the _______ pathway from the _______ to the ________.

mesolimbic; ventral tegmental area; nucleus accumbens

15

L2: What is the order of rapidity of onset from slowest to fastest? ______

Oral; Mucosal; IV; Inhalation