Unit 4: Mood Disorders, Mood Stabilizers, and ADHD

Question 1

L1: Mechanism of Action? SSRIs

Answer 1

5HT reuptake inhbition

Question 2

L1: Mechanism of Action? SNRIs

Answer 2

5HT + NE reuptake inhibition

Question 3

L1: Name the most common MAOI.

Answer 3

Phenelzine

Question 4

L1: Sex Demographics: _______ attempt more suicides; more ______ complete suicides.

Answer 4

Women; men

Question 5

L1: Which pharmacologic agent? Narrow therapeutic index antimanic agent

Answer 5

Lithium

Question 6

L2: Females tend to have more ______ symptoms in ADHD.

Answer 6

inattentive

Question 7

L2: Mechanism of Action? Bupropion

Answer 7

NE + DA reuptake inhibition

Question 8

L2: Mechanism of Action? Lithium

Answer 8

Unclear; G-protein pathways

Question 9

L2: Mechanism of Action? MAOIs

Answer 9

Blocks degradation of NE and 5HT

Question 10

L2: Mechanism of Action? Mirtazapine

Answer 10

Presynaptic alpha-2 antagonist (increases NE release)

Question 11

L2: Mechanism of Action? Trazodone

Answer 11

5HT reuptake inhibition with 5HT antagonism

Question 12

L2: Mechanism of Action? Tricyclic Antidepressants

Answer 12

NE +/- 5HT reuptake inhibition

Question 13

L2: Mechanism of Action? Valproate

Answer 13

VSSC inhibition

Question 14

L2: Name 2 SNRIs.

Answer 14

Venlafaxine, Duloxetine

Question 15

L2: Name the most common TCA.

Answer 15

Amitriptyline

Question 16

L2: Name the two most common stimulants used in the treatment of ADHD.

Answer 16

d-amphetamine (Adderall), methylphenidate (Ritalin)

Question 17

L2: Which bipolar disorder pharmacologic agent? Anti-manic agents, reasonable safety/effectiveness, risk of metabolic effects/weight gain, expensive

Answer 17

Atypical Antipsychotics

Question 18

L2: Which bipolar disorder pharmacologic agent? Anti-manic, anti-depressant, and reasonable prevention

Answer 18

Lithium

Question 19

L2: Which bipolar disorder pharmacologic agent? Individualized treatment based on weight

Answer 19

Divalproex

Question 20

L2: Which bipolar disorder pharmacologic agent? Not effective as preventative agent, sedation, not effective in bipolar depression

Answer 20

Divalproex

Question 21

L2: Which bipolar disorder pharmacologic agent? Toxic/lethal in overdose

Answer 21

Lithium

Question 22

L2: Which bipolar disorder pharmacologic agent? Tremor, taste dysfunction, thirst, cognitive dulling

Answer 22

Lithium

Question 23

L2: Which class of antidepressants? Associated with Tyramine reaction

Answer 23

MAOIs

Question 24

L2: Which class of antidepressants? Can cause anxiety and aggravation of psychosis

Answer 24

Bupropion

Question 25

L2: Which class of antidepressants? Can cause hypertension and anxiety

Answer 25

SNRIs

Question 26

L2: Which class of antidepressants? Causes sedation and antimuscarinic effects

Answer 26

TCAs

Question 27

L2: Which class of antidepressants? Contraindicated in patients with seizure disorders or eating disorders

Answer 27

Bupropion

Question 28

L2: Which class of antidepressants? Drowziness, dizziness, nausea, agitation

Answer 28

Trazodone

Question 29

L2: Which class of antidepressants? EKG abnormalities that can lead to suddent death in overdose

Answer 29

TCAs

Question 30

L2: Which class of antidepressants? Increased diastolic blood pressure

Answer 30

SNRIs

Question 31

L2: Which class of antidepressants? Inhibits CYP450 enzymes

Answer 31

SSRIs

Question 32

L2: Which class of antidepressants? Liver damage, hypertensive crisis when used with certain drugs

Answer 32

MAOIs

Question 33

L2: Which class of antidepressants? May be useful in insomnia, rapid anti-anxiety effect, low incidence of sexual side effects

Answer 33

Mirtazapine

Question 34

L2: Which class of antidepressants? More effective in severe depression

Answer 34

TCAs

Question 35

L2: Which class of antidepressants? No sexual side effects and weight neutral

Answer 35

Bupropion

Question 36

L2: Which pharmacologic agent? Effective for prevention of manic and depressive episodes in bipolar disorder

Answer 36

Lithium

Question 37

L2: Which psychiatric diagnosis? May be associated with neuroendocrine dysfunction with disinhibition of HPA axis.

Answer 37

Depression

Question 38

L3: Mechanism of Action? Electroconvulsive Therapy (ECT)

Answer 38

Increases activity of rate-limiting enzymes in 5HT and NE synthesis

Question 39

L3: Name 3 SSRIs.

Answer 39

Fluoxetine, Paroxetine, Escitalopram

Question 40

L3: Name the three cardinal signs of ADHD.

Answer 40

Excessive inattention, hyperactivity, impulsivity

Question 41

L3: SIGECAPS

Answer 41

Sleep, Interest, Guilt, Energy, Concentration/Cognition, Appetite, Psychomotor, Suicidal ideation

Question 42

L3: Which class of antidepressants? Causes orthostatic/postural hypotension

Answer 42

TCAs, MAOIs

Question 43

L3: Which class of antidepressants? Flu-like or neurologic withdrawal symptoms

Answer 43

SSRIs, SNRIs

Question 44

L3: Which class of antidepressants? Hyperthermia, myoclonus, muscle rigidity, and rapid changes in mental status and vital signs when administered with other select agents

Answer 44

SSRIs, MAOIs

Question 45

L3: Which class of antidepressants? Seizures in overdose

Answer 45

TCAs, Bupropion

Question 46

L4: Name the 4 treatments for bipolar depression in order from best to worst.

Answer 46

Quetiapine, lamotrigine, olanzapine/fluoxetine, lithium