Unit 2: Neurodegenerative Diseases Flashcards Preview

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Flashcards in Unit 2: Neurodegenerative Diseases Deck (42):
1

L1: Delirium and/or Dementia? Chronic

Dementia

2

L1: Delirium and/or Dementia? Commonly reversible

Delirium

3

L1: Delirium and/or Dementia? Fluctuations in consciousness

Delirium

4

L1: Delirium and/or Dementia? Impaired attention

Delirium

5

L1: Delirium and/or Dementia? Impaired memory

Both

6

L1: Delirium and/or Dementia? Incoherent speech/aphasia

Both

7

L1: Delirium and/or Dementia? Persistent impairment in higher intellectual functions

Dementia

8

L1: Delirium and/or Dementia? Typically toxic or metabolic causes

Delirium

9

L1: Which neurodegenerative disease? Can result from mutations in ApoE4, presenilin-1, presenilin-2, or Amyloid Precursor Protein (APP)

Alzheimer's Disease

10

L1: Which neurodegenerative disease? Formerly known as Pick's Disease

Frontotemporal Dementia (FTD)

11

L1: Which neurodegenerative disease? Most common cause of dementia in older people

Alzheimer's Disease

12

L1: Which neurodegenerative disease? Neuritic plaques and neurofibrillary tangles in the cortex and hippocampus; cerebral atrophy

Alzheimer's Disease

13

L1:Delirium and/or Dementia? Acute

Delirium

14

L2: What are the characteristic neuropathological features in Alzheimer's Disease?

Neuritic plaques and neurofibrillary tangles

15

L2: What are the characteristic neuropathological features in Parkinson Disease?

Lewy Bodies

16

L2: What brain site is primarily involved in Alzheimer's Disease?

Cortex and hippocampus

17

L2: What brain site is primarily involved in Huntington Disease?

Caudate nucleus

18

L2: What brain site is primarily involved in Parkinson Disease?

Substantia nigra

19

L2: What drug is used to antagonize the NMDA receptor in treatment of Alzheimer's Disease?

Memantine

20

L2: What neurotransmitter is deficent in Alzheimer's Disease?

Acetylcholine

21

L2: What neurotransmitter is deficient in Parkinson Disease?

Dopamine

22

L2: Which neurodegenerative disease? Abnormal tau protein metabolism

Frontotemporal Dementia (FTD)

23

L2: Which neurodegenerative disease? Autosomal dominant inheritance of expanded CAG repeat

Huntington Disease

24

L2: Which neurodegenerative disease? Caudate atrophy

Huntington Disease

25

L2: Which neurodegenerative disease? Cortical dementia with behavioral changes more pronounced than memory loss

Frontotemporal Dementia (FTD)

26

L2: Which neurodegenerative disease? Dementia and chorea, personality or behavioral changes also possible

Huntington Disease

27

L2: Which neurodegenerative disease? Dementia, gait disorder, and urinary incontinence; enlarged ventricles; periventricular white matter primarily affected

Normal Pressure Hydrocephalus

28

L2: Which neurodegenerative disease? Dementia, parkonsonism, visual hallucinations, fluctuating confusion

Lewy Body Disease

29

L2: Which neurodegenerative disease? Disinhibition, atrophy, and exectutive dysfunction; frequently misdiagnosed as a psychiatric disease

Frontotemporal Dementia (FTD)

30

L2: Which neurodegenerative disease? Disturbances in synuclein

Parkinson Disease

31

L2: Which neurodegenerative disease? Lewy Bodies in substantia nigra

Parkinson Disease

32

L2: Which neurodegenerative disease? Loss of cholinergic cells in the basal forebrain

Alzheimer's Disease

33

L2: Which neurodegenerative disease? Rapidly progressive fatal dementia, presenting with confusion, psychotic features, and myoclonus

Creutzfeldt-Jakob Disease

34

L2: Which neurodegenerative disease? Relative dopamine deficiency

Parkinson Disease

35

L2: Which neurodegenerative disease? Repeated strokes that erode cognitive function and result in dementia

Multi-infarct Dementia

36

L2: Which neurodegenerative disease? Resting tremor, bradykinesia, rigidity, postural instability

Parkinson Disease

37

L2: Which neurodegenerative disease? Vascular dementia in which longstanding hypertension leads to ischemia and lacunar infarction

Binswanger Disease

38

L3: What acetylcholinesterase inhibitors are often used in treatment of Alzheimer's Disease? (3)

Rivastigmine, donepezil, galantamone

39

L3: What is the pathogenesis of Alzheimer's Disease?

Deposition of amyloid

40

L3: What is the pathogenesis of Frontotemporal Dementia (FTD)?

Abnormal tau protein metabolism

41

L3: What is the pathogenesis of Parkinson Disease?

Disturbances in synuclein

42

L3: What three categories of drugs may be used in treatment of Alzheimer's Disease?

NMDA-antagonist, acetylcholinesterase inhibitors, atypical antipsychotics