Unit 4: Drugs of Abuse

Question 1

L1: Mechanism of Action? CNS Depressants

Answer 1

Enhance GABA activity

Question 2

L1: Mechanism of Action? CNS Stimulants

Answer 2

Release or reuptake inhibition of catecholamines

Question 3

L1: Mechanism of Action? Opioids

Answer 3

Mu-opioid agonists

Question 4

L1: Name the most commonly abused IV opioid drug.

Answer 4

Heroin

Question 5

L1: Name the three classes of CNS depressants with abuse potential.

Answer 5

Barbiturates, Benzodiazepines, Alcohol

Question 6

L1: Which agent may be used to relieve depression and reduce nicotine craving?

Answer 6

Bupropion

Question 7

L1: Which class of drugs has withdrawal symptoms that have significant risk of morbidity and mortality?

Answer 7

CNS depressants

Question 8

L1: Which class of drugs requires a taper to avoid life-threatening a withdrawal syndrome?

Answer 8

CNS Depressants

Question 9

L2: Constellation of acute toxicity symptoms associated with _________: coma, respiratory distress, pinpoint pupils, areflexia, hypotension, tachycardia

Answer 9

Opioids

Question 10

L2: Constellation of acute toxicity symptoms associated with _________: confusion, talkativness, emotional lability, ataxia, hyporeflexia, respiratory depression, miosis, coma

Answer 10

CNS Depressants

Question 11

L2: Constellation of acute toxicity symptoms associated with _________: Delirium, increases RR/BP/HR/Temp/DTRs, blank stare, stupor, seizures

Answer 11

Dissociative Anesthetics

Question 12

L2: Constellation of acute toxicity symptoms associated with _________: exaggeration of panic reaction, paranoia, confusion, palpitation, convulsions

Answer 12

hallucinogens

Question 13

L2: Constellation of acute toxicity symptoms associated with _________: nausea/vomiting, abdominal pain, salivation, diarrhea, headache/dizziness, hypotension, convulsions, respiratory pressure

Answer 13

Nicotine

Question 14

L2: Constellation of acute toxicity symptoms associated with _________: rapid pulse, increased BP and temp, sweating, increased motor activity, arrhythmia, MI, paranoid psychosis

Answer 14

CNS Stimulants

Question 15

L2: Constellation of acute toxicity symptoms associated with _________: Tremors, decrease in muscle strength/coordination, increased heart rate, seizures (epileptics), ketoacidosis (diabetics), hallucinations/delusions

Answer 15

Marijuana

Question 16

L2: Marijuana acts as an agonist at ______ receptors, which increases _____ release in the _______.

Answer 16

CB1; dopamine; nucleus accumbens

Question 17

L2: Mechanism of Action? Dissociative Anesthetics (Ketamine, Phencyclidine)

Answer 17

NMDA-receptor antagonist

Question 18

L2: Mechanism of Action? Hallucinogens

Answer 18

5HT2 agonist or increased dopamine release

Question 19

L2: Name four common CNS stimulants.

Answer 19

Cocaine, Amphetamine, Methamphetamine, Nicotine

Question 20

L2: Pharmacologic agent for treatment for opioid overdose

Answer 20

Naloxone

Question 21

L2: Pharmacologic agent for treatment of alcohol overdose

Answer 21

IV fluids, glucose, vitamins, electrolytes

Question 22

L2: Pharmacologic agent for treatment of benzodiazepine overdose

Answer 22

Flumazenil

Question 23

L2: Pharmacologic agent for treatment of CNS stimulant-induced psychosis

Answer 23

Haloperidol

Question 24

L2: Pharmacologic agent for treatment of CNS stimulant-induced seizures

Answer 24

Diazepam

Question 25

L2: Which agent is a partial agonist at nicotinic receptors, enabling block of cigarette nicotine effects?

Answer 25

Varenicline

Question 26

L2: Which agent may be used for relapse prevention of opioids via action at adrenergic receptors?

Answer 26

Clonidine

Question 27

L2: Which agent may be used for withdrawal alleviation and blocking heroine reinforcement via partial agonism at mu-opioid receptors?

Answer 27

Buprenorphine

Question 28

L2: Which agent may be used for withdrawal alleviation and relapse prevention of opioids via long-acting mu-opioid agonism?

Answer 28

Methadone

Question 29

L2: Which agent may be used to block reinforcing actions of heroin via opioid receptor antagonism but has poor treatment retention?

Answer 29

Naltrexone

Question 30

L2: Which agent may be used to relieve relapse rate in alcoholics?

Answer 30

Topiramate

Question 31

L2: Which class of drugs develops strong psychologic dependence but minimal if any physical dependence

Answer 31

CNS Stimulants

Question 32

L2: Which class of drugs rarely produces tolerance, physical dependence, or withdrawal?

Answer 32

hallucinogens

Question 33

L2: Which symptom of BZDs do not usually develop tolerance?

Answer 33

Anterograde amnesia

Question 34

L2: Which symptoms of Nicotine use show tolerance?

Answer 34

Subjective effects; nausea

Question 35

L3: Name 4 drug classes of addiction that develop physical dependence

Answer 35

Opioids, CNS depressants, nicotine, marijuana