Flashcards in Unit 4: Drugs of Abuse Deck (35):
1
L1: Mechanism of Action? CNS Depressants
Enhance GABA activity
2
L1: Mechanism of Action? CNS Stimulants
Release or reuptake inhibition of catecholamines
3
L1: Mechanism of Action? Opioids
Mu-opioid agonists
4
L1: Name the most commonly abused IV opioid drug.
Heroin
5
L1: Name the three classes of CNS depressants with abuse potential.
Barbiturates, Benzodiazepines, Alcohol
6
L1: Which agent may be used to relieve depression and reduce nicotine craving?
Bupropion
7
L1: Which class of drugs has withdrawal symptoms that have significant risk of morbidity and mortality?
CNS depressants
8
L1: Which class of drugs requires a taper to avoid life-threatening a withdrawal syndrome?
CNS Depressants
9
L2: Constellation of acute toxicity symptoms associated with _________: coma, respiratory distress, pinpoint pupils, areflexia, hypotension, tachycardia
Opioids
10
L2: Constellation of acute toxicity symptoms associated with _________: confusion, talkativness, emotional lability, ataxia, hyporeflexia, respiratory depression, miosis, coma
CNS Depressants
11
L2: Constellation of acute toxicity symptoms associated with _________: Delirium, increases RR/BP/HR/Temp/DTRs, blank stare, stupor, seizures
Dissociative Anesthetics
12
L2: Constellation of acute toxicity symptoms associated with _________: exaggeration of panic reaction, paranoia, confusion, palpitation, convulsions
hallucinogens
13
L2: Constellation of acute toxicity symptoms associated with _________: nausea/vomiting, abdominal pain, salivation, diarrhea, headache/dizziness, hypotension, convulsions, respiratory pressure
Nicotine
14
L2: Constellation of acute toxicity symptoms associated with _________: rapid pulse, increased BP and temp, sweating, increased motor activity, arrhythmia, MI, paranoid psychosis
CNS Stimulants
15
L2: Constellation of acute toxicity symptoms associated with _________: Tremors, decrease in muscle strength/coordination, increased heart rate, seizures (epileptics), ketoacidosis (diabetics), hallucinations/delusions
Marijuana
16
L2: Marijuana acts as an agonist at ______ receptors, which increases _____ release in the _______.
CB1; dopamine; nucleus accumbens
17
L2: Mechanism of Action? Dissociative Anesthetics (Ketamine, Phencyclidine)
NMDA-receptor antagonist
18
L2: Mechanism of Action? Hallucinogens
5HT2 agonist or increased dopamine release
19
L2: Name four common CNS stimulants.
Cocaine, Amphetamine, Methamphetamine, Nicotine
20
L2: Pharmacologic agent for treatment for opioid overdose
Naloxone
21
L2: Pharmacologic agent for treatment of alcohol overdose
IV fluids, glucose, vitamins, electrolytes
22
L2: Pharmacologic agent for treatment of benzodiazepine overdose
Flumazenil
23
L2: Pharmacologic agent for treatment of CNS stimulant-induced psychosis
Haloperidol
24
L2: Pharmacologic agent for treatment of CNS stimulant-induced seizures
Diazepam
25
L2: Which agent is a partial agonist at nicotinic receptors, enabling block of cigarette nicotine effects?
Varenicline
26
L2: Which agent may be used for relapse prevention of opioids via action at adrenergic receptors?
Clonidine
27
L2: Which agent may be used for withdrawal alleviation and blocking heroine reinforcement via partial agonism at mu-opioid receptors?
Buprenorphine
28
L2: Which agent may be used for withdrawal alleviation and relapse prevention of opioids via long-acting mu-opioid agonism?
Methadone
29
L2: Which agent may be used to block reinforcing actions of heroin via opioid receptor antagonism but has poor treatment retention?
Naltrexone
30
L2: Which agent may be used to relieve relapse rate in alcoholics?
Topiramate
31
L2: Which class of drugs develops strong psychologic dependence but minimal if any physical dependence
CNS Stimulants
32
L2: Which class of drugs rarely produces tolerance, physical dependence, or withdrawal?
hallucinogens
33
L2: Which symptom of BZDs do not usually develop tolerance?
Anterograde amnesia
34
L2: Which symptoms of Nicotine use show tolerance?
Subjective effects; nausea
35