Unit 4: Drugs of Abuse Flashcards Preview

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Flashcards in Unit 4: Drugs of Abuse Deck (35):
1

L1: Mechanism of Action? CNS Depressants

Enhance GABA activity

2

L1: Mechanism of Action? CNS Stimulants

Release or reuptake inhibition of catecholamines

3

L1: Mechanism of Action? Opioids

Mu-opioid agonists

4

L1: Name the most commonly abused IV opioid drug.

Heroin

5

L1: Name the three classes of CNS depressants with abuse potential.

Barbiturates, Benzodiazepines, Alcohol

6

L1: Which agent may be used to relieve depression and reduce nicotine craving?

Bupropion

7

L1: Which class of drugs has withdrawal symptoms that have significant risk of morbidity and mortality?

CNS depressants

8

L1: Which class of drugs requires a taper to avoid life-threatening a withdrawal syndrome?

CNS Depressants

9

L2: Constellation of acute toxicity symptoms associated with _________: coma, respiratory distress, pinpoint pupils, areflexia, hypotension, tachycardia

Opioids

10

L2: Constellation of acute toxicity symptoms associated with _________: confusion, talkativness, emotional lability, ataxia, hyporeflexia, respiratory depression, miosis, coma

CNS Depressants

11

L2: Constellation of acute toxicity symptoms associated with _________: Delirium, increases RR/BP/HR/Temp/DTRs, blank stare, stupor, seizures

Dissociative Anesthetics

12

L2: Constellation of acute toxicity symptoms associated with _________: exaggeration of panic reaction, paranoia, confusion, palpitation, convulsions

hallucinogens

13

L2: Constellation of acute toxicity symptoms associated with _________: nausea/vomiting, abdominal pain, salivation, diarrhea, headache/dizziness, hypotension, convulsions, respiratory pressure

Nicotine

14

L2: Constellation of acute toxicity symptoms associated with _________: rapid pulse, increased BP and temp, sweating, increased motor activity, arrhythmia, MI, paranoid psychosis

CNS Stimulants

15

L2: Constellation of acute toxicity symptoms associated with _________: Tremors, decrease in muscle strength/coordination, increased heart rate, seizures (epileptics), ketoacidosis (diabetics), hallucinations/delusions

Marijuana

16

L2: Marijuana acts as an agonist at ______ receptors, which increases _____ release in the _______.

CB1; dopamine; nucleus accumbens

17

L2: Mechanism of Action? Dissociative Anesthetics (Ketamine, Phencyclidine)

NMDA-receptor antagonist

18

L2: Mechanism of Action? Hallucinogens

5HT2 agonist or increased dopamine release

19

L2: Name four common CNS stimulants.

Cocaine, Amphetamine, Methamphetamine, Nicotine

20

L2: Pharmacologic agent for treatment for opioid overdose

Naloxone

21

L2: Pharmacologic agent for treatment of alcohol overdose

IV fluids, glucose, vitamins, electrolytes

22

L2: Pharmacologic agent for treatment of benzodiazepine overdose

Flumazenil

23

L2: Pharmacologic agent for treatment of CNS stimulant-induced psychosis

Haloperidol

24

L2: Pharmacologic agent for treatment of CNS stimulant-induced seizures

Diazepam

25

L2: Which agent is a partial agonist at nicotinic receptors, enabling block of cigarette nicotine effects?

Varenicline

26

L2: Which agent may be used for relapse prevention of opioids via action at adrenergic receptors?

Clonidine

27

L2: Which agent may be used for withdrawal alleviation and blocking heroine reinforcement via partial agonism at mu-opioid receptors?

Buprenorphine

28

L2: Which agent may be used for withdrawal alleviation and relapse prevention of opioids via long-acting mu-opioid agonism?

Methadone

29

L2: Which agent may be used to block reinforcing actions of heroin via opioid receptor antagonism but has poor treatment retention?

Naltrexone

30

L2: Which agent may be used to relieve relapse rate in alcoholics?

Topiramate

31

L2: Which class of drugs develops strong psychologic dependence but minimal if any physical dependence

CNS Stimulants

32

L2: Which class of drugs rarely produces tolerance, physical dependence, or withdrawal?

hallucinogens

33

L2: Which symptom of BZDs do not usually develop tolerance?

Anterograde amnesia

34

L2: Which symptoms of Nicotine use show tolerance?

Subjective effects; nausea

35

L3: Name 4 drug classes of addiction that develop physical dependence

Opioids, CNS depressants, nicotine, marijuana