Unit 2: Nociception Flashcards Preview

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Flashcards in Unit 2: Nociception Deck (27):
1

L1: Excess sensitization of nociceptors is referred to as _______.

primary hyperalgesia

2

L1: First pain/pin prick sensation is mediated by __-type fibers

A-delta

3

L1: Second pain/burning sensation is mediated by __-type fibers

C

4

L1: Sensitization strong enough to allow non-noxious stimuli to trigger a painful sensation is known as ________.

Allodynia

5

L1: Stimulation of ______ in the midbrain produces powerful analgesia

Periaqueductal Gray (PAG) matter

6

L1: The major excitatory transmitter released by primary nociceptive sensory neurons is ______.

Glutamate

7

L1: The spinothalamic tract conveys nociceptive information to the _____.

Somatosensory cortex

8

L2: A flare results from the release of ______ from collaterals of C fibers in the wheal area

Substance P

9

L2: Acitvation of non-nociceptive fibers leads to activation of ________ in the dorsal horn.

Inhibitory interneurons

10

L2: Capsaicin acticates the ____ receptor

Villanoid (VR1)

11

L2: Cold nociceptors are __ fibers.

C

12

L2: Cold receptors detect temperatures: ___

10-37 degree Celsius

13

L2: In response to stress, there is increased activity in the _______ which increases activation of the PAG

limbic system

14

L2: In the spinal cord, ATP activates microglial cells that release ____, changing the reversal potential of _____ channels.

BDNF; chloride

15

L2: In the spinal cord, descending neurons from the nucleus raphe activate ________.

Inhibitory interneurons

16

L2: Inhibitory interneurons use _____ presynaptically and postsynaptically to reduce pain

Enkephalin

17

L2: Mechanical nociceptors are __ fibers.

A-delta

18

L2: PAG neurons project to the ______ in the medulla, which projects to the spinal cord via the ________.

Nucleus raphe magnus; dorsal lateral funiculus

19

L2: Polymodal receptors are __ fibers.

C

20

L2: The spinomesenphalic tract conveys nociceptive information to the _____.

Midbrain Periaqueductal Gray (PAG) region

21

L2: The spinoreticular tract conveys nociceptive information to the _____.

Hypothalamus

22

L2: Warm nociceptors are __ fibers.

A-delta

23

L2: Warm receptors detect temperatures: ____

30-48 degrees Celsius

24

L3: In the placebo effect, the PAG pathway is activated by secretion of _____ due to activity in the _______.

endorphins; cortex or limbic systems

25

L3: Name 4 activators of nociceptors

Bradykinin, potassium, serotonin, acid

26

L3: Which three tracts in the brain convey information from nociceptive fibers?

Spinothalamic, Spinoreticular, spinomesenphalic

27

L4: Name 5 sensitizers of nociceptors

Prostaglandins, Substance P, ATP, ACh, serotonin