Flashcards in Unit 4: Anxiety Disorders and Anxiolytic-Sedative Agents Deck (22):
L1: _______: recurrent thoughts, images, or impulses that are intrusive and cause anxiety
L1: _______: repetitive behaviors or mental acts that are performed inorder to reduce anxiety
L1: Mechanism of Action? Benzodiazepines
Facilitate GABA transmission
L1: Mechansim of Action? Barbiturates
Facilitate GABA transmission, Depress glutamate transmission
L1: What is the GABA subunit specificity for "Z" drugs?
alpha-1 subunit only
L1: What is the GABA subunit specificity for BZDs?
alpha-1 and alpha-2/alpha-5
L1: Which disorder? Palpitations, tachycardia, shortness of breath, sweating, tembling, paresthesias, fear of dying
L1: Which disorder? Excessive worry, including anxiety and tension; 5% lifetime prevalence
Generalized Anxiety Disorder
L1: Which disorder? Fear to leave home to do anxiety
L1: Which disorder? High comorbidity with Tourette Syndrome
L1: Which disorder? Overwhelming anxiety in situations where one would have to interact with others, perform in front of others, or be the center of attention
L2: Mechanism of Action? Buspirone
5HT1A partial agonist
L2: Name 2 barbiturate agents.
L2: Name a BZD with reliable intramuscular administration
L2: What class of sedative/anxiolytic drugs are first line in acute panic disorder?
L2: Which anxiolytic agent has no sedative, anticonvulsant, or myelorelaxant aeffects?
L2: Which pharmacologic agent acts as an antagonist at benzodiazepine binding sites to reverse CNS effects of BZDs?
L2: Which pharmacology agents have a withdrawal syndrome characterized by decreaed appetite, nausea, fatigue, tachycardia, insomnia, depression, weight loss, and possbile seizures? Which class of agents is more prone to this syndrome?
BZDs and Barbiturates; barbiturates
L2: Which sedative agents induce P450 metabolism?
L2: Why are BZDs inferior agents for chronic management of anxiety disorders?
L3: Name 3 BZDs with fast oral absorption
Alprazolam, Triazolam, Diazepam