Unit 4: Anxiety Disorders and Anxiolytic-Sedative Agents Flashcards Preview

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Flashcards in Unit 4: Anxiety Disorders and Anxiolytic-Sedative Agents Deck (22):
1

L1: _______: recurrent thoughts, images, or impulses that are intrusive and cause anxiety

Obsessions

2

L1: _______: repetitive behaviors or mental acts that are performed inorder to reduce anxiety

Compulsions

3

L1: Mechanism of Action? Benzodiazepines

Facilitate GABA transmission

4

L1: Mechansim of Action? Barbiturates

Facilitate GABA transmission, Depress glutamate transmission

5

L1: What is the GABA subunit specificity for "Z" drugs?

alpha-1 subunit only

6

L1: What is the GABA subunit specificity for BZDs?

alpha-1 and alpha-2/alpha-5

7

L1: Which disorder? Palpitations, tachycardia, shortness of breath, sweating, tembling, paresthesias, fear of dying

Panic Disorder

8

L1: Which disorder? Excessive worry, including anxiety and tension; 5% lifetime prevalence

Generalized Anxiety Disorder

9

L1: Which disorder? Fear to leave home to do anxiety

Agoraphobia

10

L1: Which disorder? High comorbidity with Tourette Syndrome

Obsessive-Compulsive Disorder

11

L1: Which disorder? Overwhelming anxiety in situations where one would have to interact with others, perform in front of others, or be the center of attention

Social Phobia

12

L2: Mechanism of Action? Buspirone

5HT1A partial agonist

13

L2: Name 2 barbiturate agents.

Phenobarbital, pentobarbital

14

L2: Name a BZD with reliable intramuscular administration

Lorazepam

15

L2: What class of sedative/anxiolytic drugs are first line in acute panic disorder?

BZDs

16

L2: Which anxiolytic agent has no sedative, anticonvulsant, or myelorelaxant aeffects?

Buspirone

17

L2: Which pharmacologic agent acts as an antagonist at benzodiazepine binding sites to reverse CNS effects of BZDs?

Flumazenil

18

L2: Which pharmacology agents have a withdrawal syndrome characterized by decreaed appetite, nausea, fatigue, tachycardia, insomnia, depression, weight loss, and possbile seizures? Which class of agents is more prone to this syndrome?

BZDs and Barbiturates; barbiturates

19

L2: Which sedative agents induce P450 metabolism?

Barbiturates

20

L2: Why are BZDs inferior agents for chronic management of anxiety disorders?

Dependence

21

L3: Name 3 BZDs with fast oral absorption

Alprazolam, Triazolam, Diazepam

22

L4: Name 8 BZD agents.

Alprazolam, Midazolam, Triazolam, Diazepam, Flurazepam, Lorazepam, Oxazepam, Temazepam