Signal Transduction - RTKs

Question 1

What are the 2 types of tyrosine kinase linked receptors?

Answer 1

Receptor tyrosine kinases
Cytokine receptors

Question 2

What do the phosphorylated tyrosine domains attract/activate?

Answer 2

Proteins with SH2 domains

Grb2 protein

Question 3

What does the phosphorylated intracellular Tyr by SH2(P) stimulate?

Answer 3

Protein Ras and downstream cascade

Question 4

What does the Ras protein activate?

Answer 4

RAF signal transduction pathway

Question 5

What does the kinase cascade lead to?

Answer 5

Various transcription factors and gene transcription

Question 6

When does the kinase cascade become unregulated?

Answer 6

Cancer, doesn’t need GF to activate pathway

Question 7

What ligand generally binds to RTK?

Answer 7

Growth ligand

Question 8

What site on the RTK is phosphorylated?

Answer 8

tyr residue

Question 9

What are cytokine receptors associated with?

Answer 9

haematopoiesis and immunity (including inflammation and wound healing)