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BDS2.5 Applied Biomedical Sciences > Innate Immunity > Flashcards

Innate Immunity Flashcards

1
Q

What are the professional phagocytes?

A

Monocytes
Macrophages
Granulocytes
Dendritic cells

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2
Q

How long does the innate immune response take to activate?

A

0-4 hours

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3
Q

When the macrophage engulfs the pathogen, what is the pathogen encased in?

A

Phagosome

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4
Q

What does the phagosome fuse with?

A

Lysosome

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5
Q

What is inside the lysosome?

A

Chemicals and enzymes

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6
Q

What is a monocyte?

A

Immature macrophages

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7
Q

When monocytes become macrophages, where do they reside?

A

Tissue

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8
Q

What do you call the fraction of the pathogen which macrophages display in their cell surface?

A

Antigen

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9
Q

What do the macrophages displaying a pathogenic antigen on surface display it to?

A

mhc2 complex

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10
Q

What is the difference between MHC1 and MHC2?

A

MHC1 = cells with a nucleus and express as antigen on the MHC1
MHC2 = antibody response

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11
Q

What is the ,last abundant WBC?

A

Neutrophils

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12
Q

Compare neutrophil and macrophage

A

Neutrophils are not APC, just eat pathogen

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13
Q

What do NKC do?

A

Phagocytose cells

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14
Q

Do the NKC use the roll-stop-exit method?

A

Yes

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15
Q

What do the NKC secrete?

A

Perforin

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16
Q

How do the NKC kill cells?

A

MAC complex = suicide

FasL interact with Fas on the surface of target cell = suicide

17
Q

What does IL-12 and TNF from the macrophage cause the NKC to do?

A

Recruit and activate NKC

18
Q

What does IL-2 secreted by the NKC cause the NKC cell to do?

A

Proliferate

19
Q

In turn, what does the NKC secrete to recruit and activate more macrophages to amplify response?

A

IFN-y

20
Q

What MHC does the NKC detect?

A

MHC1 as it is innate immune response

21
Q

What at the 2 types of inflammatory inflammation?

A

Acute or chronic inflammation

BDS2.5 Applied Biomedical Sciences (48 decks)

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