Adrenergic Drugs Flashcards Preview

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Flashcards in Adrenergic Drugs Deck (37):
1

uses of epinephrine

anaphylactic shock
asthmatic attacks
cardiac arrest
local anesthesia so drug persists at site before being absorbed and metabolized

2

adverse effects of epi

CNS disturbances
hemorrhage
cardiac arrhythmias
pulmonary edema

3

what does epi do in the presence of hyperthyroidism, cocaine, and beta blockers

-for hyperthyroidism and cocaine, it increases/enhances cardiovascular actions

-in those on beta blockers, since beta receptors are not available, all the epi goes to the alpha receptors causing an increase in peripheral resistance hence high BP

4

effect of norepinephrine if given after pre treatment of atropine

causes tachycardia because atropine is a muscarinic antagonist so effects are enhanced

5

uses of norepinephrine

blood pressure control in those that are hypotensive
cardiogenic and septic shock

6

what is dopamine used for

severe congestive heart failure
cardiogenic and septic shock

7

adverse effects of dopamine

nausea, hypertension, arrhythmias (like NE and E)

8

D1 receptor agonist that is used for peripheral vasodilation used to tx severe hypertension in hospitals

fenoldopam

9

what is isoproterenol used for and what receptor does it work on

non selective beta agonist

in emergencies to stimulate heart rate in patients with bradycardia or heart block

10

CV, pulmonary, and other effects of isoproterenol

- CV - stimulates heart rate and contractility (beta 1), decrease peripheral resistance (beta 2)
- pulmonary - bronchodilation
- GI SM is relaxed, hyperglycemia, lipolysis

11

what receptor does dobutamine work on

beta 1 agonist

12

uses of dobutamine

- increase cardiac output in management of heart failure
- management of cardiogenic shock

13

short acting beta 2 agonists used in the treatment of asthma as a bronchodilator

terbutaline and albuterol

14

long acting beta 2 agonists used in the treatment of asthma as a bronchodilator

salmeterol and formoterol

15

adverse effects of beta 2 agonist drugs

tremor, restlessness, apprehension, anxiety

16

receptor does phenylephrine works on and its uses

alpha 1 agonist
- nasal decongestant
- to increase BP in those that are hypotensive
- mydriasis

17

receptor does clonidine work on

- partial alpha 2 agonist
- activates central alpha adrenoreceptors

18

uses of clonidine

to reduce sympathetic outflow from CNS

19

adverse effects of clonidine

lethargy, sedation, xerostomia

20

what happens to methyldopa when taken up

it is converted to methylnorepinephrine by alpha 2 adrenoreceptors

21

use of methyldopa

used for the treatment of hypertension during pregnancy because it is safe for mother and the fetus

22

adverse effects of methyldopa

sedation, mental lassitude, impaired mental concentration, dry mouth

23

alpha 2 agonist that is administered ocularly to lower intraocular pressure in persons with glaucoma

brimonidine

24

indirect acting adrenergic agonist that is a releasing agent aka it causes norepinephrine release from presynaptic terminals

amphetamine, methylphenidate, tyramine

25

what is amphetamine used for

to treat ADHD and narcolepsy

26

what is a structural analogue of amphetamine and is also used to treat ADHD and narcolepsy

methylphenidate

27

if a patient is taking MAO inhibitors, this drug can precipitate serious vasopressor episodes

tyramine

28

what is cocaine used for

topical anesthesia of the upper respiratory tract

29

what does cocaine do chemically

it blocks the reuptake of dopamine into neurons of the pleasure center hence producing euphoria

30

treatments for ADHD

methylphenidate, amphetamine, atomoxetine

31

chemically how does atomoxetine work

inhibitor of NET (norepinephrine reuptake transporter)

32

treatments of narcolepsy

amphetamine, methylphenidate, modafinil

33

how does modafinil work

inhibitor of norepinephrine and dopamine transporters
increases synaptic conc of NE, dopamine, serotonin, and glutamate
decrease GABA levels

34

what is ephedrine used for

-pressor agent during spinal anesthesia when hypotension frequent
-bronchial asthma
-myasthenia gravis

35

how does ephedrine work

it activates alpha and beta receptors and releases NE

36

what drug does ephedrine have a synergistic effect with in the tx of myasthenia gravis

anticholinesterases like pyridostigmine and neostigmine

37

what is pseudoephedrine

ephedrine enantiomers that is used as a component of nasal decongestant and is found in combination with H1 histamine antagonist

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