Immunopharmacology II Flashcards Preview

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Flashcards in Immunopharmacology II Deck (14):
1

what are the classes of immunosuppressive antibodies

I-MOP

Immunostimulants
Monoclonal antibodies
Other Biological Agents
Polyclonal Antibodies

2

what are the polyclonal antibodies

Antithymocite globulin
Rho(D) immunoglobulin

3

uses of antithymocite globulin (ATG) anti lymphocyte globulin (ALG)

used before stem cell transplantation to prevent graft vs. host reaction

4

uses of Rho (D) immunoglobulin

given to Rho(D) negative women after exposure to antigen (birth of Rho(D) + baby) to prevent erythroblastosis fetalis/hemolytic anemia of newborn in future pregnancies

5

what are the monoclonal antibodies

AEIOB

Adalimumab
Etanercept
Infliximab
Omalizumab
Basiliximab

6

of all the monoclonal antibodies, which are the anti TNFα and what are they at an increased risk of developing

Adalimumab, Etanercept, Infliximab

increased risk of infection or reactivating TB, hep B, and systemic fungi

7

what are all the anti TNFα used to treat (name them)

Adalimumab, Etanercept, Infliximab

RA
Ankylosing Spondylitis
Psoriatic arthritis
IBD

8

adverse effects of anti TNFα (name them)

Adalimumab, Etanercept, Infliximab

cytopenias
serious infections like bacterial sepsis and TB
increased risk of malignancies

9

mechanism of Omalizumab

binds to IgE --> prevents it from binding to mast cells and basophils --> prevents release of inflamm mediators after allergen exposure

10

mechanism of Basiliximab

chimeric human mouse IgG that binds to IL-2 receptor on activated lymphocytes

aka IL-2 receptor antagonist

11

what are the OTHER biological agents and mechanism

RAA

Rituximab - binds to CD20 on B cells causing depletion of circulating B cells

Abatacept - fusion protein that interferes with T cell activation

Anakinra - IL-1 receptor antagonist

12

what are the immunostimulants

ABI

Aldesleukin
BCG
Inteferons

13

what do immunostimulants do/ treat

stimulate immune response including tx for immune deficiency diseases, chronic infectious diseases, cancer

14

what is aldesleukin

a recombinant IL-2 that promotes production of cytotoxic T lymphocytes and activates NK cells

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