Antihyperlipidemic Drugs II Flashcards Preview

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Flashcards in Antihyperlipidemic Drugs II Deck (15):
1

what is the cholesterol absorption inhibitor

ezetimbe

2

mechanism of ezetimbe

- selective inhibitor of a transport protein (NPC1L1) in jejunal enterocytes which takes up cholesterol from lumen --> compensatory increase in cholesterol synthesis (inhibit with statin) --> reduced intestinal cholesterol delivered to liver --> upregulation of LDL receptors --> increased LDL clearance from plasma

really effective as a dual therapy with statin

3

why is ezetimbe effective even in absence of dietary cholesterol

inhibits reabsorption of cholesterol excreted in bile

4

what is ezetimbe used for

- as a dual therapy for patients on statin who can't reach their LDL goal
- only used as monotherapy in those who can't tolerate statin (more effective as a dual therapy)

5

adverse effects of ezetimbe

reversible impaired hepatic function
myositis (inflammation and degeneration of muscle tissue)

6

drug interaction of ezetimbe

bile acid sequestrant (cholestyramine, colestipol, colesevelam) inhibits absorption of ezetimbe so should not be given together

7

what are the omega 3 FA

EPA, DHA, and Lovaza

8

what do the fish oils do

EPA and DHA reduce TAG synthesis, increase FA oxidation in the liver, and long term may increase HDL

9

what does lovaza do

with adjuvant to proper diet can reduce TAGs in pts with high levels ( greater than 500mg/dL)

10

suggest drug if isolated severe hypertriglyceridemia

fibrate (or niacin or fish oil)
then add a statin

11

Statin is first line drug for what profiles

elevated LDL
elevated LDL and TAGs
isolated low HDL

12

which antihyperlipidemic drug is contraindicated in pregnant women

statins
category X

13

antihyperlipidemic that is teratogenic in animals and should only be used in pregnant women if benefits outweigh the risks

fibrates - gemfibrozil and fenofibrate
category C

14

antihyperlipidemic drugs that interferes with absorption of nutrients

cholestyramine and colestipol
category C

15

antihyperlipdemic drug that causes skeletal defects in animals

ezetimbe
category C

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