Rheumatoid Arthritis Drugs Flashcards Preview

Pharmacology > Rheumatoid Arthritis Drugs > Flashcards

Flashcards in Rheumatoid Arthritis Drugs Deck (17):
1

what is Rheumatoid Arthritis

immunologic disease that causes systemic effects which shortens life and joint disease that reduces mobility and quality of life

2

what is RA driven by

activated T cells given rise to IL-1 and TNF

3

classes of drugs used to treat RA

NSAIDs
Glucocorticoids
DMARDs

4

of all the classes, which ones reduces or prevents joint damage/ stop progression of the disease

DMARDs (disease modifying antirheumatic drugs)

NSAIDs and glucocorticoids treat symptoms and improve quality of life but do not slow down progression of RA

5

first DMARD prescribed whether it is mild, moderate, or severe in RA

Methotrexate

6

what are the non biological DMARDs

CC HALMS

Cyclosporine
Cyclophosphamide

Hydroxychloroquine
Azathioprine
Leflunomide
Methotrexate
Sulfasalazine

7

what are the biological DMARDs

Anti-TNF-α: Adalimumab, Etanercept, Infliximab

Rituximab
Abatacept
Anakinra

8

patients who do not respond to methotrexate alone should be given what in adjuvant

Leflunomide

9

least toxic of all DMARDs but least effective as a monotherapy

Hydroxychloroquine

10

side effect of Cyclosporine

GOHN

Gum Hyperplasia
Osteoporosis
Hirsutism
NEPHROTOXICITY

11

situation is cyclophosphamide reserved for

severe RA with systemic features like vasculitis

12

name the Anti-TNF-α drugs used to treat RA again

Adalimumab
Etanercept
Infliximab

13

which of the treatments of RA act more quickly

the Anti-TNF-α act more quickly than the non biological DMARDs

14

what are NSAIDs used for in RA

anti inflammatory actions

bridge drugs for relief of symptoms

15

first line biological agent for RA

Anti-TNF-α: Adalimumab, Etanercept, Infliximab

16

increased risk of what adverse effect is increased with use of methotrexate with leflunomide

hepatotoxicity

17

why is it not best to have a combination of different biological agents

increases the risk of infection

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