Antidiabetic Drugs III Flashcards Preview

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Flashcards in Antidiabetic Drugs III Deck (16):
1

bile acid sequestrant

Colesevelam

2

AE of bile acid sequestrant

colesevelam

Constipation
Nausea
Dyspepsia
Increase TAG levels
Interfere with absorption of oral drugs

3

SGLT2 inhibitor

Canagliflozin

4

mechanism of SGLT2 inhibitor

Canagliflozin

SGLT2 responsible for the most glucose reabsorption --> inhibit it --> decreased glucose absorption, increased glucose excretion, and decreased blood glucose levels

5

AE of SGLT2 inhibitor

Canagliflozin

Genital and Urinary Tract Infection
Osmotic diuresis --> hypotension, volume depletion, increased creatinine levels, hyperkalemia, hypermagnesemia, hyperphosphatemia

6

contraindication of SGLT2 inhibitor

GFR less than 45ml/min/1.73 m2

7

drug usually given if metformin is contraindicated

Sulfonylurea
Pioglitazone
Sitagliptin

8

what determines if insulin would be given to a type II diabetic

person with high HbA1c level especially if greater than 8.5%

9

major cause of morbidity and mortality in diabetic patients

Cardiovascular Disease

10

drugs used for neuropathic pain in diabetics (for dystal symmetric polyneuropathy)

GAP DOVV

Gabapentin
Amitriptyline
Pregabalin

Duloxetine
Opioids
Venlafaxine
Valproate

11

gastroparesis can be treated with what

metoclopramide and erythromycin

12

DOC for preggo with diabetes

Regular human insulin: short acting insulin

13

mechanism of glucagon

works via Gs --> increase in cAMP --> release of glucose from liver

14

effect of glucagon on heart and SM

heart: potent inotropic and chronotropic effect without using beta receptor

SM: relaxation of intestine

15

uses of glucagon

GRaBS

Glucagon C peptide test (test for residual beta cell function in DM)
Radiology of Bowel (relax intestine)
Beta blocker poisoning
Severe Hypoglycemia

16

AE of glucagon

nausea and vomiting

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