Hypothalmic and Pituitary Hormones II Flashcards Preview

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Flashcards in Hypothalmic and Pituitary Hormones II Deck (21):
1

what are the gonadotropin analogues

Follitropin
Urofollitropin
hCG
Menotropins

2

hCG mimics what actions

actions of LH and is obtained from urine of pregnant women

3

main source of menotropins

urine of pregnant women

4

what is urofillitropin

highly purified FSH preparation

5

in women what is the purpose of FSH and LH

ovarian follicle development and ovarian steroidogenesis

6

what is the use of gonadotropins

used for those who are infertile to stimulate spermatogenesis in men and ovulation in women with anovulation that is secondary to hypogonadotropic hypogonadism

7

adverse effects of gonadotropins and hCG use in men and women

men - gynecomastia
women - ovarian hyperstimulation syndrome and multiple pregnancies

8

what are the ACTH analogues

Corticotropin (ACTH itself)
Cosyntropin (recombinant ACTH)

9

uses of ACTH analogues

-diagnose suspect cases of adrenal insufficiency
-diagnose if insufficiency is primary or secondary

10

function of oxytocin

muscular contraction --> milk release during lactation and uterine contraction

11

mechanism of oxytocin

works via Gq and G11 --> IP3 and DAG --> increased Ca2+ --> stimulate release of prostaglandins and leukotrienes

12

used outside the united states to prevent pre term labor

Atosiban - oxytocin antagonist

13

when is Vasopressin released

falling BP or increased tonicity

14

mechanism of vasopressin

-Gq: works on V1 receptor found on vascular SM and mediates vasoconstriction

-Gs: works on V2 receptor on renal tubule cells and decreases diuresis via increased water permeability and resorption

15

what happens if ADH disrupted

-excess ADH: SIADH
-deficient ADH: diabetes insipidus

16

what is used to treat diabetes insipidus

vasopressin
desmopressin (long acting vasopressin analogue)

17

what else is vasopressin used to treat

Esophageal varices bleeding
Colonic Diverticular bleeding

18

what else is desmopressin used to treat

Coagulopathy in Hemophilia A and von willebrand disease

19

side effects of vasopressin and desmopressin

hyponatremia
seizures

20

vasopressin antagonist and its mechanism

Conivaptan --> V1 and V2 receptor antagonist

21

what is vasopressin antagonist used to treat

Conivaptan --> SIADH induced hyponatremia

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