Adrenergic Drugs II Flashcards Preview

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Flashcards in Adrenergic Drugs II Deck (34):
1

non selective alpha adrenergic blocker

phenoxybenzamine, phentolamine,

2

drugs used to treat pheochromocytoma

phenoxybenzamine and phentolamine

3

what drug should be given alongside phenoxybenzamine

beta blocker since alpha blocker phenoxybenzamine can cause tachycardia but make sure not to give beta blocker until alpha blockade has been established so as not to have increased vasoconstriction due to unopposed beta blocker

4

adverse effects of phenoxybenzamine

postural hypotension, nasal stuffiness, nausea, vomiting

inhibit ejaculation

5

what does phentolamine block

alpha 1 and alpha 2 blocker

6

type of patient is phentolamine contraindicated in

those with decreased coronary perfusion

7

what is phentolamine used for

-pheochromocytoma (and for its diagnosis)
-prevention of dermal necrosis
-hypertensive crisis in general

8

alpha 1 selective adrenergic blockers

prazosin, terazosin, doxazosin, tamsulosin,

TT DP

9

what is prasozin used to treat

hypertension because it causes relaxation of both arterial and venous SM

10

what are terazosin and doxazosin used for

tx of hypertension and BPH
they have longer half life so require less frequent dosing

11

what receptor is tamsulosin selective for and its importance

alpha 1A receptor antagonist
which is specific for genitourinary tract

12

main use of tamsulosin

treatment of BPH (urinary retention) because of its specificity as an alpha 1A receptor blocker

not very helpful treating hypertension

13

alpha 2 selective blocker

yohimbine

14

what is yohimbine used for

to treat antihypertensive effects of alpha 2 agonist clonidine (was used to treat erectile dysfunction)

15

non selective beta antagonist

propanolol, timolol, and nadolol

16

propanolol, timolol, nadolol are contraindicated in what type of patients and why

those with COPD and asthma because of blockage of beta 2 which leads to contraction of bronchial SM hence leading to a respiratory crisis

also kind of diabetics especially after they take their insulin injection since their beta 2 receptor is blocked on the liver and skeletal muscle hence less glycogenolysis and gluconeogenesis (hence glucose level has to be watched)

17

what is propanolol used to treat

hypertension, glaucoma, migraine, hyperthyroidism, angina pectoris, atrial fibrillation, myocardial infarction, performance anxiety (stage fright), essential tremor

18

beta blocker are contraindicated in what type of heart problem

variant angina

19

adverse effects of beta blockers

-bronchoconstriction
-affect recovery from hypoglycemia in insulin dependent diabetics
-mask tachycardia that is seen in hypoglycemia as a warning sign
-affect lipolysis
-CNS effects

20

why shouldn't beta blocker be stopped abruptly

to avoid tachycardia, hypertension, and ischemia

21

what is nadolol used for

-long term management of angina pectoris
-hypertension

22

what is tomolol used for

-hypertension
-prophylaxis for migraine
-open angle glaucoma

23

beta one selective antagonist

atenolol, metoprolol, esmolol

MEA

24

uses of atenolol and metoprolol

-hypertension
-angina pectoris long term
-acute MI

25

use of esmolol

better since it is short acting hence safer
-supraventricular arrhythmias
-arrhythmias associated with thyrotoxicosis, periop hypertension, myocardial ischemia

26

alpha 1 and beta blocker

labetalol and carvedilol

27

what is labetalol used for

hypertension

28

adverse effects of labetalol

orthostatic hypotension and dizziness
hepatic injury

29

what is carvedilol used for

hypertension and CHF

30

chemically how does pindolol work and what is its use

partial beta agonist
hypertension

31

adrenergic drugs that act presynaptically

alpha methyltyrosine (metyrosine), reserpine, tetrabenazine

32

chemically how does metyrosine work and what is its use

it inhibits tyrosine hydroxylase which turn tyr to dopa

used as an adjuvant to phenoxybenzamine to treat pheochromocytoma

33

how does reserpine work and what is it used for

irreversible inhibitor of VMAT leading to depletion of NE

hypertension

34

how does tetrabenazine work and what is it used for

reversible inhibitor of VMAT

chorea associated with Huntington's

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