Anticancer Drugs III Flashcards Preview

Pharmacology > Anticancer Drugs III > Flashcards

Flashcards in Anticancer Drugs III Deck (13):
1

what are the classes of signal transduction inhibitors

BRAPE

BCR-ABL and C-KIT inhibitor
RAS/MAP Kinase pathway inhibitor
Angiogenesis Inhibitor
Proteasome Inhibitor
EGFR (ErbB1) and HER2/neu (ErbB2) inhibitor

2

inhibitor of EGFR/ErbB1 tyrosine kinase

Gefitinib
Erlotinib

3

monoclonal antibody against EGFR/ErbB1

Cetuximab

4

monoclonal antibody against HER2/neu (ErbB2)

Trastuzumab

5

adverse effect of monocolonal antibody against HER2/neu (ErbB2) -- name it

Trastuzumab

cardiotoxic

6

inhibitor of EGFR (ErbB1) and HER2/neu (ErbB2)

Lapatinib

GECTL

7

inhibitor of BCR-ABL and C-KIT

Imatinib

8

inhibitor of RAS/MAP kinase pathway

Sorafenib

9

name the proteasome inhibitor and mechanism

Bortezomib

induces growth inhibition and apoptosis of tumor cells

10

angiogenesis inhibitor and mechanism

Sunitinib

inhibits VGEFR-1, VGEFR-2, PDGFR

11

mechanism of Asparginase

hydrolyzes circulating L-asparagine to aspartic acid ammonia --> depleting tumor cells of asparagine needed for protein synthesis

12

mechanism of hydroxyurea

inhibits ribonucleotide reductase needed to form deoxyribonucleoside diphosphate from ribonucleoside diphosphate

13

mechanism of IFNalpha

-stimulates natural killer cells to kill transformed cells
-increases expression of HLA molecules on tumor cells

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