Anticancer Drugs III

Question 1

what are the classes of signal transduction inhibitors

Answer 1

BRAPE

BCR-ABL and C-KIT inhibitor
RAS/MAP Kinase pathway inhibitor
Angiogenesis Inhibitor
Proteasome Inhibitor
EGFR (ErbB1) and HER2/neu (ErbB2) inhibitor

Question 2

inhibitor of EGFR/ErbB1 tyrosine kinase

Answer 2

Gefitinib

Erlotinib

Question 3

monoclonal antibody against EGFR/ErbB1

Answer 3

Cetuximab

Question 4

monoclonal antibody against HER2/neu (ErbB2)

Answer 4

Trastuzumab

Question 5

adverse effect of monocolonal antibody against HER2/neu (ErbB2) – name it

Answer 5

Trastuzumab

cardiotoxic

Question 6

inhibitor of EGFR (ErbB1) and HER2/neu (ErbB2)

Answer 6

Lapatinib

GECTL

Question 7

inhibitor of BCR-ABL and C-KIT

Answer 7

Imatinib

Question 8

inhibitor of RAS/MAP kinase pathway

Answer 8

Sorafenib

Question 9

name the proteasome inhibitor and mechanism

Answer 9

Bortezomib

induces growth inhibition and apoptosis of tumor cells

Question 10

angiogenesis inhibitor and mechanism

Answer 10

Sunitinib

inhibits VGEFR-1, VGEFR-2, PDGFR

Question 11

mechanism of Asparginase

Answer 11

hydrolyzes circulating L-asparagine to aspartic acid ammonia –> depleting tumor cells of asparagine needed for protein synthesis

Question 12

mechanism of hydroxyurea

Answer 12

inhibits ribonucleotide reductase needed to form deoxyribonucleoside diphosphate from ribonucleoside diphosphate

Question 13

mechanism of IFNalpha

Answer 13

• stimulates natural killer cells to kill transformed cells

- increases expression of HLA molecules on tumor cells