Bone Mineral Homeostasis II Flashcards Preview

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Flashcards in Bone Mineral Homeostasis II Deck (17):
1

what is Cinecalcet

activates calcium sensing receptors in PTH cells --> decreased PTH synthesis and release

2

use of Cincecalcet

secondary hyperparathyroidism in chronic renal disease

hyperparathyroidism in patients with parathyroid carcinoma

3

AE of cincecalcet

Nausea
Hypocalcemia

4

Fluoride's role in calcium homeostasis

chronic exposure --> new bone synthesis --> more dense but brittle

5

Gallium nitrate's role in calcium homeostasis

inhibits bone resorption --> used in cancer related hypercalcemia

6

AE of Gallium nitrate

nephrotoxic

7

Miscellaneous affecting calcium homeostasis

FGPT

Fluoride
Gallium Nitrate
Plicamycin
Thiazides

8

drugs used for cancer related hypercalcemia

Gallium nitrate and Plicamycin

9

mechanism of Plicamycin (other name for it)

Mithracin

cytotoxic cancer drug

10

AE of plicamycin

TRH

Thrombocytopenia
Renal Toxicity
Hepatic Toxicity

11

drugs that cause osteoporosis

CHAAL

Corticosteroids
Heparin
Anastrozole
Alcohol
Lithium

12

Drugs that cause osteomalacia

Phenytoin
Etridonate (used longer than 12 months)

13

mechanism of thiazides in calcium homeostasis

increases reuptake of calcium and decreases its excretion

14

uses of thiazides

-hypertension in those with osteoporosis
-treats hypercalciuria or kidney stones

15

how do hypercalcemia patients present

-stones (nephrolithiasis)
-groans (abdominal pain)
-bones (bone pain, myalgia, arthralgia, fracture)
-thrones (sit on throne for polyuria)
-psychiatric overtones (fatigue, depression, anxiety, sleep disturbances)

16

treatment of hypercalcemia

Furosemide (loop diuretic) and saline solution
Bisphosphonates (RAPE)
Calcitonin
Parathyroidectomy

17

treatment of osteoporosis

-Stop smoking, alcohol abuse, corticosteroid
-HRT in post menopausal women
-Calcium and Vit D supplements
-Bisphosphonates
-SERMs
-Teriparatide

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