Migraine Drugs Flashcards
drugs for acute treatment of migraine
NADES
NSAIDs Acetaminophen Dihydroergotamine Ergotamine Sumatriptan
drugs taken for mild to moderate acute migraine
Acetaminophen
NSAIDs
Dihydroergotamine, Ergotamine, and Sumatriptan are for moderate to severe
mechanism of triptans
agonists of 5-HT1B and 5-HT1D
adverse effects of triptans
tingling, flushing, dizziness, drowsiness, fatigue, pressure in chest, MI, arrhythmias
contraindications of triptans
coronary, cerebrovascular, or arterial disease
uncontrolled hypertension
mechanism of dihydroergotamine and ergotamine
agonist of alpha adrenoreceptors, 5-HT1B/D, and D2 receptors
adverse effects of dihydroergotamine and ergotamine
nausea and vomiting controlled by metoclopramide
vascular occlusion and gangrene
first line agents used for prevention of migraine
Beta blockers
Anti epileptics
beta blockers used for prevention of migraine
P MANT propanolol metoprolol atenolol nadolol timolol
anti epileptics used as first line prevention of migraine
Valproate
Topiramate
mechanism and adverse effects of valproate
inhibits voltage gated Na channels and T type Ca channels
Thrombocytopenia and Teratogenic
mechanism and adverse effects of Topiramate
inhibits voltage gated Na channels, agonist of GABA receptor, glutamate R antagonist
Myopia, Cognitive slowing, Hyperthermia
second line agents for prevention of migraine
NCAA ABS
NSAIDs
CCB: verapamil
ACEIs and ARBs: Lisinopril and Candesartan
Antidepressants: Amitriptyline, Nortriptyline, Imipramine
Antiepileptic: Gabapentin
Botulinum Toxin
SNRI: Venlafaxine
mechanism of Gabapentin
decreases glutamate release via blockage o presynaptic voltage gated Ca channels
