Migraine Drugs Flashcards Preview

Pharmacology > Migraine Drugs > Flashcards

Flashcards in Migraine Drugs Deck (14):
1

drugs for acute treatment of migraine

NADES

NSAIDs
Acetaminophen
Dihydroergotamine
Ergotamine
Sumatriptan

2

drugs taken for mild to moderate acute migraine

Acetaminophen
NSAIDs

Dihydroergotamine, Ergotamine, and Sumatriptan are for moderate to severe

3

mechanism of triptans

agonists of 5-HT1B and 5-HT1D

4

adverse effects of triptans

tingling, flushing, dizziness, drowsiness, fatigue, pressure in chest, MI, arrhythmias

5

contraindications of triptans

coronary, cerebrovascular, or arterial disease
uncontrolled hypertension

6

mechanism of dihydroergotamine and ergotamine

agonist of alpha adrenoreceptors, 5-HT1B/D, and D2 receptors

7

adverse effects of dihydroergotamine and ergotamine

nausea and vomiting controlled by metoclopramide

vascular occlusion and gangrene

8

first line agents used for prevention of migraine

Beta blockers
Anti epileptics

9

beta blockers used for prevention of migraine

P MANT
propanolol
metoprolol
atenolol
nadolol
timolol

10

anti epileptics used as first line prevention of migraine

Valproate
Topiramate

11

mechanism and adverse effects of valproate

inhibits voltage gated Na channels and T type Ca channels

Thrombocytopenia and Teratogenic

12

mechanism and adverse effects of Topiramate

inhibits voltage gated Na channels, agonist of GABA receptor, glutamate R antagonist

Myopia, Cognitive slowing, Hyperthermia

13

second line agents for prevention of migraine

NCAA ABS

NSAIDs
CCB: verapamil
ACEIs and ARBs: Lisinopril and Candesartan
Antidepressants: Amitriptyline, Nortriptyline, Imipramine

Antiepileptic: Gabapentin
Botulinum Toxin
SNRI: Venlafaxine

14

mechanism of Gabapentin

decreases glutamate release via blockage o presynaptic voltage gated Ca channels

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